Fabiola Moretti
Fabiola Moretti
affiliation: National Research Council of Italy - Institute of Cell Biology and Neurobiology
research area(s): Cell Biology, Molecular Biology
Course: Experimental Endocrinology, Metabolism and Endocrine Surgery
University/Istitution: Università Cattolica del Sacro Cuore
1985 : Degree with honours in Biological Sciences, University of Rome "La Sapienza" with an experimental thesis
1998: Post-graduate degree with honors in Medical Genetic, University of Rome "La Sapienza"
1987-1989 : Collaborator in the Inherited and Metabolic Disease Section, Dept. of Experimental Medicine, University of Rome "La Sapienza"
1989 - : Staff member, Institute of Nurobiology and Moelcular Medicine - National Council of Research, Rome, Italy.
1994 : Consultant for the National Olimpic Committee
1993 - 2007 : Visiting scientist at the Molecular Oncogenesis Laboratory - "Regina Elena" Cancer Institute (Italy)
1998-1999 : Visiting Scientist at the Dept. of Molecular Cell Biology - University of Leiden (The Netherlands)
2000 - today: Group Leader .
2002 - 2005: Teacher of the Ph.D Course "Endocrinology and Molecular Medicine" at the University "La Sapienza" of Roma
2005- today: Tutor of the Ph.D Course "Endocrine-metabolic and experimental endocrine-surgical Sciences" at the Catholic University of Rome
2008-today: Teacher of the PhD course in Scienze Endocrinologiche e Metaboliche Sperimentali at the University degli Studi di Messina

The interest of this group is related to the mechanisms that regulate the cell response to stress signals mostly those involved in the activation of the cell cycle arrest or cell death outcomes. Particularly, research projects aim to understand the role of the MDM proteins, MDM2 and MDM4 in the growth arrest and apoptotic responses and in the regulation of the oncosuppressor p53 activity, in normal and tumor cells (with particular attention to the endocrine tumors).
Selected 2005-2011
S. Giglio, F. Mancini, F. Gentiletti, G. Sparaco, L. Felicioni, F. Barassi, C. Martella, A. Prodosmo, S. Iacovelli, F. Buttitta, A. Farsetti, S. Soddu, A. Marchetti, A. Sacchi, A. Pontecorvi, F. Moretti (2005) Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: a New Mechanism for HDM2 Stabilization Cancer Research, 65: 9687-9694

Rinaldo C., Prodosmo A., Mancini F., Iacovelli S., Sacchi A., Moretti F., Soddu S. (2007) MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Molecular Cell, 25: 739-750.

Prodosmo A., Giglio S., Moretti S., Mancini F., Barbi F., Avenia N., Di Conza G., Schunemann H.J., Pisola L., Ludovini V., Sacchi A., Pontecorvi A., Puxeddu E., Moretti F. (2008) Analysis of human MDM4 (HDMX) variants in papillary thyroid carcinomas reveals new potential predictors of cancer features J. Molecular Medicine, 86: 585-596.

Grasselli A, Nanni S, Colussi C, Aiello A, Benvenuti V, Ragone G, Moretti F, Sacchi A, Bacchetti S, Gaetano C, Capogrossi MC, Pontecorvi A, Farsetti A. (2008) Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase. Circ Res. 103: 34-42.

Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F. (2009) Mdm4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic apoptotic pathway. EMBO J. 28: 1926-39

Mancini F, Moretti F. (2009) Mitochondrial MDM4 (MDMX): an unpredicted role in the p53-mediated intrinsic apoptotic pathway. Cell Cycle 8: 1-6

Nucera C, Muzzi P, Tiveron C, Farsetti A, La Regina F, Foglio B, Shih SC, Moretti F, Della Pietra L, Mancini F, Sacchi A, Trimarchi F, Vercelli A, Pontecorvi A. (2009) Maternal thyroid hormones cross the placenta and are transcriptionally active during embryonic development: results from a transgenic mouse model. J Cell Mol Med. 14: 2417-35

F. Mancini, G. Di Conza, O. Monti, A. Macchiarulo, R. Pellicciari, A. Pontecorvi, F. Moretti (2010) Puzzling over MDM4-p53 network. Int J Biochem Cell Biol.42:1080-1083

Giglio S., Mancini F., Pellegrino M., Di Conza G., Puxeddu E., Sacchi A., Pontecorvi A., Moretti F. (2010) Regulation of MDM4 (MDMX) function by p76MDM2: a new facet in the control of p53 activity. Oncogene 29: 5935-45.

A. Macchiarulo, N. Giacchè, F. Mancini, E. Puxeddu, F. Moretti, R.Pellicciari (2011) Alternative Strategies for targeting MDM2 activity with small molecules: novel patents on the horizon ? Expert Opinion On Therapeutic Patents, 21: 287-94
No projects are available to students for the current accademic year.