Nicoletta Zoppi
e-mail: zoppi AT med.unibs.it
affiliation: Università di Brescia
research area(s): Cell Biology, Cancer Biology
Course:
Molecular Genetics, Biotechnologies and Experimental Medicine
University/Istitution: Università di Brescia
University/Istitution: Università di Brescia
1989 Degree in Biological Sciences,University of Pavia, Italy.
1994 Degree in Biochemical and Clinic Chemical Sciences (Scuola di Specialità in Biochimica e Chimica clinica),University of Brescia.
1989-1996 Research fellowships from USSL n41 of Brescia and Ente Universitario Lombardia Orientale(EULO), Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology,University of Brescia.
2001 PhD in Molecular Genetics applied to Medical Sciences (Dottorato di Ricerca in Genetica Molecolare applicata alle Scienze Mediche), Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia.
1999 Assistant Professor in Applied Biology (SSD BIO/13) at the University of Brescia, Department of Biomedical Sciences and Biotechnology, Division of Biology and Genetics.
2011 Associate Professor in Applied Biology (SSD BIO/13) at the University of Brescia, Department of Biomedical Sciences and Biotechnology, Division of Biology and Genetics.
From 2000 Member of Associazione Italiana di Biologia e Genetica (AIBG)
From 2009 Member of the International Society for Matrix Biology (ISMB).
1994 Degree in Biochemical and Clinic Chemical Sciences (Scuola di Specialità in Biochimica e Chimica clinica),University of Brescia.
1989-1996 Research fellowships from USSL n41 of Brescia and Ente Universitario Lombardia Orientale(EULO), Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology,University of Brescia.
2001 PhD in Molecular Genetics applied to Medical Sciences (Dottorato di Ricerca in Genetica Molecolare applicata alle Scienze Mediche), Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia.
1999 Assistant Professor in Applied Biology (SSD BIO/13) at the University of Brescia, Department of Biomedical Sciences and Biotechnology, Division of Biology and Genetics.
2011 Associate Professor in Applied Biology (SSD BIO/13) at the University of Brescia, Department of Biomedical Sciences and Biotechnology, Division of Biology and Genetics.
From 2000 Member of Associazione Italiana di Biologia e Genetica (AIBG)
From 2009 Member of the International Society for Matrix Biology (ISMB).
The research activity has always been focused on the study of cell biology mechanisms mediated by the extracellular matrix, such as cell adhesion, proliferation and survival, and cell migration.
Expression and organization of extracellular matrix proteins in fibroblasts derived from patients affected with Inherited Connective tissue Disorders: Ehlers-Danlos syndrome, Arterial Tortuosity syndrome, dystrophic epidermolysis bullosa.
Definition of molecular strategies for the extracellular matrix remodelling.
Characterization of integrins-mediated transduction pathways involved in the cell survival, adhesion and migration.
Expression and organization of extracellular matrix proteins in fibroblasts derived from patients affected with Inherited Connective tissue Disorders: Ehlers-Danlos syndrome, Arterial Tortuosity syndrome, dystrophic epidermolysis bullosa.
Definition of molecular strategies for the extracellular matrix remodelling.
Characterization of integrins-mediated transduction pathways involved in the cell survival, adhesion and migration.
1.Drera B, Gaula A, Zoppi N, Gardella R, Franceschini P, Barlati S, Colombi M 2007 Two novel SLC2A10/GLUT10 mutations in a patient with arterial Tortuosity Syndrome.Am J Med Genet A 143:216-218
2.Zoppi N, Ritelli M, Salvi A, Colombi M, Barlati S 2007 The FN13 peptide inhibits human tumor cells invasion through the modulation of αvβ3 integrins organization and the inactivation of ILK. Biochimica et Biophysica Acta-Mol Cell Res 1773:747-763
3.Drera B, Brezzi A, Zoppi N, Venturini M, Barlati S, Calzavara-Pinton PG, Colombi M 2008 Compound heterozygosity for a novel and a recurrent ABCC6 gene mutation in an Italian family with pseudoxanthoma elasticum. J Dermatol Sci 49: 252-255
4. Viglio S, Zoppi N, Sangalli A, Gallanti A, Barlati S, Mottes M, Colombi M, Valli M 2008 Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1. J Invest Dermatol 128:1915-1919
5.Zoppi N, Barlati S, Colombi M 2008 FAK independent, avb3integrin-EGFR complexes rescue from anoikis matrix-defective fibroblasts. Biochimica et Biophysica Acta-Mol Cell Res 1783:1177-1188
6.Borsani G, Piovani G, Zoppi N, Bertini V, Bini R, Notarangelo L, Barlati S 2008 Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype. Eur J Med Genet 51:292-302
7.Viglio S, Zoppi N, Sangalli A, Gallanti A, Barlati S, Mottes M, Colombi M, Valli M 2008 Wound repair capability in EDS fibroblasts can be retrieved by exogenous type V collagen. TheScientificWorldJOURNAL 8:956–958
8.Drera B, Ritelli M, Tadini G, Zoppi N, Venturini M, Calzavara-Pinton PG, Barlati S, Colombi M 2009 The novel p.G150R missense mutation in the cartilage matrix protein subdomain of type VII collagen in compound heterozigosity with the c.682+1G>A COL7A1 splicing mutation leads to mild dystrophic epidermolysis bullosa. J Dermatol Sci 53:222-225
9.Drera B, Ritelli M, Zoppi N, Wischmeijer A, Gnoli M, Fattori R, Calzavara-Pinton PG, Barlati S, Colombi M 2009 Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients. Orphanet Journal of Rare Diseases 4:24-26
10.Chiarelli N, Ritelli M, Zoppi N, Benini A, Borsani G, Barlati S, Colombi M 2011 Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Int J Dev Biol [Epub ahead of print 2011, Mar 31] PMID:21553381
2.Zoppi N, Ritelli M, Salvi A, Colombi M, Barlati S 2007 The FN13 peptide inhibits human tumor cells invasion through the modulation of αvβ3 integrins organization and the inactivation of ILK. Biochimica et Biophysica Acta-Mol Cell Res 1773:747-763
3.Drera B, Brezzi A, Zoppi N, Venturini M, Barlati S, Calzavara-Pinton PG, Colombi M 2008 Compound heterozygosity for a novel and a recurrent ABCC6 gene mutation in an Italian family with pseudoxanthoma elasticum. J Dermatol Sci 49: 252-255
4. Viglio S, Zoppi N, Sangalli A, Gallanti A, Barlati S, Mottes M, Colombi M, Valli M 2008 Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1. J Invest Dermatol 128:1915-1919
5.Zoppi N, Barlati S, Colombi M 2008 FAK independent, avb3integrin-EGFR complexes rescue from anoikis matrix-defective fibroblasts. Biochimica et Biophysica Acta-Mol Cell Res 1783:1177-1188
6.Borsani G, Piovani G, Zoppi N, Bertini V, Bini R, Notarangelo L, Barlati S 2008 Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype. Eur J Med Genet 51:292-302
7.Viglio S, Zoppi N, Sangalli A, Gallanti A, Barlati S, Mottes M, Colombi M, Valli M 2008 Wound repair capability in EDS fibroblasts can be retrieved by exogenous type V collagen. TheScientificWorldJOURNAL 8:956–958
8.Drera B, Ritelli M, Tadini G, Zoppi N, Venturini M, Calzavara-Pinton PG, Barlati S, Colombi M 2009 The novel p.G150R missense mutation in the cartilage matrix protein subdomain of type VII collagen in compound heterozigosity with the c.682+1G>A COL7A1 splicing mutation leads to mild dystrophic epidermolysis bullosa. J Dermatol Sci 53:222-225
9.Drera B, Ritelli M, Zoppi N, Wischmeijer A, Gnoli M, Fattori R, Calzavara-Pinton PG, Barlati S, Colombi M 2009 Loeys-Dietz syndrome type I and type II: clinical findings and novel mutations in two Italian patients. Orphanet Journal of Rare Diseases 4:24-26
10.Chiarelli N, Ritelli M, Zoppi N, Benini A, Borsani G, Barlati S, Colombi M 2011 Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Int J Dev Biol [Epub ahead of print 2011, Mar 31] PMID:21553381
Project Title:
EXPRESSION, ORGANIZATION AND REMODELLING OF EXTRACELLULAR MATRIX PROTEINS.
The analysis at transcriptional and post-transcriptional levels of the extracellular matrix (ECM) proteins, of their organization and interaction with specific integrin receptors and the identification of specific signal transduction pathways will be performed in human skin fibroblasts derived from patients affected by Ehlers-Danlos syndrome, a group of inherited connective tissue disorders caused by fibrillar collagens genes mutations.The identification of molecular strategies capable to remodel ECM components, and to modulate integrins settings, switching on transduction signalling regulating the cell adhesion, survival and migration, should add insights on the etiopathogenesis and therapeutic approaches of this disease.
The role of the facilitative glucose/ascorbic acid transporter GLUT10 in the organization and remodelling of ECM in mutant fibroblasts and aortic smooth muscle cells derived from patients affected by Arterial Tortuosity syndrome, a rare inherited connective/cardiovascular tissue disorder caused by SLC2A10/GLUT10 gene mutations, will be studied.These data should add insights to the molecular and functional cross-talk mechanisms between ECM integrin receptors and other transmembrane proteins involved in the synthesis, folding and assembly of ECM components.
The role of the facilitative glucose/ascorbic acid transporter GLUT10 in the organization and remodelling of ECM in mutant fibroblasts and aortic smooth muscle cells derived from patients affected by Arterial Tortuosity syndrome, a rare inherited connective/cardiovascular tissue disorder caused by SLC2A10/GLUT10 gene mutations, will be studied.These data should add insights to the molecular and functional cross-talk mechanisms between ECM integrin receptors and other transmembrane proteins involved in the synthesis, folding and assembly of ECM components.