Giuliana Pelicci
Giuliana Pelicci
affiliation: IEO - Istituto Europeo di Oncologia
research area(s): Stem Cells And Regenerative Medicine, Neuroscience
Course: Molecular Medicine: Molecular Oncology and Computational Biology
University/Istitution: Università di Milano, UNIMI-SEMM
1984 Medical Doctor, University of Perugia, Italy.
1989 Specialization in Internal Medicine, University of Perugia, Italy.
1994 Ph.D. in Molecular and Cellular Biology, University of Perugia, Italy.
Scientific Profile
1983-1987 Pre- and postdoctoral fellow in Clinical Endocrinology at the "Istituto di Clinica Medica I", School of Medicine, University of Perugia, Italy.
1987-1995 Post-doctoral fellow in Cellular and Molecular Biology, University of Perugia.
1996- 2002 Staff Scientist, Dpt of Experimental Oncology, IEO, Milan, Italy.
2002-2004 Senior Staff Scientist, Dpt of Experimental Oncology, IEO, Milan, Italy.
Since 2005- Group Leader, Dpt of Experimental Oncology, IEO, Milan, Italy.
Academic Position held:
1993 " 1997 Reader in Experimental Oncology, University of Perugia, Medical School, Italy.
2002-2003 Reader in Molecular Biology, University of Perugia, Biotechnology, Italy.
Since 2005 Faculty member of European School of Molecular Medicine, Molecular Medicine P.h.D. Program. Milan, Italy.
2010 Associate Professor of Clinical Biochemistry, University of Perugia, Italy
Actual position Group Leader, Dpt of Experimental Oncology, IEO, Milan, Italy.
Scientific Achievements:
Cloning of the Shc gene and the Shc related gene (Rai/ Shc C). Definition of the role of Shc proteins in signal transduction from activated RTKs to Ras. Definition of the role of p66shc in the control of life -span in mammals.

1: Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1. Erreni M, Solinas G, Brescia P, Osti D, Zunino F, Colombo P, Destro A, Roncalli M, Mantovani A, Draghi R, Levi D, Rodriguez Y Baena R, Gaetani P, Pelicci G, Allavena P.
Eur J Cancer. 2010 Aug 19 IF 4.388

2: Savino MT, Ortensi B, Ferro M, Ulivieri C, Fanigliulo D, Paccagnini E, Lazzi S, Osti D, Pelicci G, Baldari CT. Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation.
J Immunol. 2009 Jan 1;182(1):301-8. IF: 5.646

3: Villanacci V, Bassotti G, Ortensi B, Fisogni S, Cathomas G, Maurer CA, Galletti A, Salerni B, Pelicci G. Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system.
Neurogastroenterol Motil. 2008 Mar;20(3):206-12. Epub 2007 Sep 27.
IS- 1350-1925 (Print) IF 3,338

4: Peviani M, Cheroni C, Troglio F, Quarto M, Pelicci G, Bendotti C. Lack of changes in the PI3K/AKT survival pathway in the spinal cord motor neurons of a mouse model of familial amyotrophic lateral sclerosis.
Mol Cell Neurosci. 2007 Apr;34(4):592-602. Epub 2007 Jan 11.
IS- 1044-7431 (Print) IF 4,607

5: Urbanelli L, Emiliani C, Massini C, Persichetti E, Orlacchio A, Pelicci G, Sorbi S, Hasilik A, Bernardi G, Orlacchio A. Cathepsin D expression is decreased in Alzheimer's disease fibroblasts.
Neurobiol Aging. 2008 Jan;29(1):12-22. Epub 2006 Oct 17.
IS- 1558-1497 (Electronic) IF 5,599

6: De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM. RAI(ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors.
Oncogene. 2005 Sep 15;24(41):6303-13.
IS- 0950-9232 (Print) IF 6,582

7: Troglio F, Echart C, Gobbi A, Pawson T, Pelicci PG, De Simoni MG, Pelicci G. From The Cover: The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia.
Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15476-81. Epub 2004 Oct 19.
IS- 0027-8424 (Print) IF 9,643

8: Emiliani C, Urbanelli L, Racanicchi L, Orlacchio A, Pelicci G, Sorbi S, Bernardi G, Orlacchio A.
Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation.
J Biol Chem. 2003 Oct 3;278(40):38453-60.
IS- 0021-9258 (Print) IF 5,808

9: Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
Mol Cell Biol. 2002 Oct;22(20):7351-63.
IS- 0270-7306 (Print)
IF 6,773
10: Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
J Biol Chem. 2002 May 10;277(19):16798-804.
IS- 0021-9258 (Print) IF 5,808

11: Conti L, Sipione S, Magrassi L, Bonfanti L, Rigamonti D, Pettirossi V, Peschanski M, Haddad B, Pelicci P, Milanesi G, Pelicci G, Cattaneo E.
Shc signaling in differentiating neural progenitor cells.
Nat Neurosci. 2001 Jun;4(6):579-86.
IS- 1097-6256 (Print) IF 14,805
Project Title:
Potential projects will be discussed with interested students.
Potential projects will be discussed with interested students.