Graziano Guella
Graziano Guella
affiliation: Università di Trento
research area(s): Chemical Biology
Course: Biomolecular Sciences
University/Istitution: Università di Trento

He was educated at High School Liceo Classico "A.Maffei" di Riva del Garda where he reached the Diplom in 1975 (60/60) and at "the University of Padova where he was graduated in Chemistry summa cum laude in 1981 (110/110 cum laude). The Master thesis "EPR investigation of exciton triplets in molecular crystals of charge-transfer complexes" was carried at the "Physical Chemistry Institute" of Padova under the supervision of prof. Carlo Corvaja. Then he moved to the University of Trento where he started his research activity in marine natural products chemistry and gained a permanent position as Associate Researcher in 1986 in the Bioorganic Chemistry Laboratory at the Physics Department of the University of Trento. Since 2002 he is "Associate Professor" in Organic Chemistry at the Faculty of Sciences of the University of Trento (Italy).He is a Member of the Italian Chemical Society and of the Italian Protistology Society

Research activities:
He is author of about 150 scientific publications on refereed International Journals of Organic Chemistry and Physical Organic Chemistry and he has discussed these scientific results in Invited or Oral communications in national and international Conferences. He is a peer reviewer of national/international research grants and of prestigious International Journals.
During the years his attention has focused on 4 main research areas:
1) Natural products chemistry through investigation of structural, synthetic and biological aspects of marine secondary metabolites, isolated both from micro- and macroorganisms. Isolation, structural characterization of new molecules, total synthesis, micromolecular chemotaxonomy, drug design and discovery, lipid profiling of natural membranes, bio-prospecting, environmental and analytical chemistry, biomass analysis, sustainable development are the main aspects tackled in our approach. 2) Biophysical and biological chemistry: bindings in non-covalent host-guest complexes, supramolecular chemistry, MS and NMR measurements on artificial membranes, liposomes, micelles and bicelles, structural characterization of pore-forming peptides. 3) Physical and Theoretical Chemistry: NMR kinetics measurements on metal-catalyzed processes (borohydrides), conformational analysis, mechanistic investigations of ion-molecules processes in MS ion-sources, gas phase oxidations of nucleobases, ab initio computations on small-medium organic molecules or complexes, vibrational analysis of natural products . 4) Food chemistry: structural characterization of grapes derived natural products, investigation of the molecular mechanisms in the fruit ripening
1. Cervia D., Martini D., Garcia-Gil M., Di Giuseppe G., Guella G., Dini F., Bagnoli P. Cytotoxic effects and apoptotic signalling mechanisms of the sesquiterpenoid euplotin C, a secondary metabolite of the marine ciliate Euplotes crassus, in tumour cells”, Apoptosis, 2006, 11(5), 829-843
2. Ascenzi D. Franceschi P, Guella G.,Tosi P. “Phenol Production in Benzene/Air Plasmas at Atmospheric Pressure. Role of Radical and Ionic Routes”. Journal of Physical Chemistry A 2006, 110(25), 7841-7847
3. Defant A, Guella G., Mancini I., Regioselectivity in the multi-component synthesis of indolizinoquinoline-5,12- dione derivatives., European Journal of Organic Chemistry 2006, (18), 4201-4210.
4. Frassanito R, Flaim G., Mancini I., Guella G. High production of unexpected carotenoids in Dinophyceae. Astaxanthin-esters of the freshwater dinoflagellate Tovellia sanguinea , Biochemical Systematics and Ecology 2006, 34(12), 843-853
5. Tomazzolli R., Dalla Serra M., Bellisola G., Colombatti M., Guella G. A fluorescence-based assay for the reductase activity of protein disulfide isomerase, Analytical Biochemistry 2006, 350(1), 105-112.
6. Guella G., N’Diaye I., Fofana M., Mancini I. Isolation, Synthesis and Photochemical Properties of Almazolone, a New Indole Alkaloid from a Red Alga of Senegal , Tetrahedron 2006, 62(6), 1165-1170
7. Ramoino, P; Usai, C; Diaspro, A; Bianchini, P; Guella, G; Dini, F “Euplotin C modulates dihydropyridinesensible calcium channels in Paramecium” Cytometry Part A 2006 69A (5):444-444ISSN 1552-4922
8. Guella G., Zanchetta C. Patton B., Miotello, A. New Insights on the Mechanism of Palladium-Catalyzed Hydrolysis of Sodium Borohydride from 11B-NMR Measurements, Journal of Physical Chemistry B 2006, 110(34), 17024-17033.
9. Rossi B., Verrocchio P., Villani G, Scarduelli G, Guella G., Mancini I, Vibrational properties of inclusion complexes: The case of indomethacin-cyclodextrin, Journal of Chemical Physics 2006, 125(4), 044511/1-044511/7.
10. Drechsler A.,Sabo J., Potrich C., Frisanco M., Guella G., Dalla Serra M., Anderluh G., Separovic F., Norton R.S. Structure and Activity of the N-Terminal Region of the Eukaryotic Cytolysin Equinatoxin II., Biochemistry 2006, 45(6), 1818-1828
11. Mancini I:, Guella G., Frostin M., Hnawia E., Laurent D., Debitus C., Pietra F., On the first PolyArsenic Organic Compound from Nature:Arsenicin A from the New Caledonian Marine Sponge Echinochalina bargibanti, Chemistry European Journal. 2006, 12, 8989-8994
12. Koss D., Hindley K., David K., Mancini I., Guella G., Sepcic K., Turk T., Rebolj K., Riedel G., Platt B., Scott R. H., "A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurons". BMC Pharmacology, 2007, 7, n. 1.
13. Guella G., Ascenzi D., Franceschi P., Tosi P., "The intriguing case of organic impurities contained in synthetic metanol: a mass spectrometry based investigation". Rapid Communications in Mass Spectrometry, 2007, 21, 3337-3344
14. Mancini I., Defant A., Guella G., "Recent synthesis of marine natural products with antibacterial activities". Anti-infective Agents in Medicinal Chemistry, 2007, 6, 17-48,
15. Zanchetta C., Patton B., Guella G., Miotello A., An integrated apparatus for production and measurement of molecular hydrogen. Measurement Science and Technology, 2007, 18, 21-26
16. Cervia D., Garcia-gil M., Simonetti E., Di Giuseppe G., Guella G., Bagnoli P., Dini F., Molecular mechanisms of euplotin C-induced apoptosis: involvement of mitochondrial dysfunction, oxidative stress and proteases. Apoptosis, 2007, 12, 1349-1363
17. Rossi B., Verrocchio P., Viliani G., Scarduelli G., Mancini I., Guella G., Rossi F., Vibrational dynamics of inclusion complexes by Raman scattering: an experimental and numerical study. Philosophical magazine, 2007, 87, 559-567
18. Defant A., Guella G., Mancini I., Synthesis and in vitro cytotoxicity evaluation of novel naphthindolizinedione derivatives. Archive der Pharmazie. Chemistry in Life Sciences, 2007, 340, 147-153
19. Ramoino P., Usai C., Maccione S., Beltrame F., Diaspro A., Fato M., Guella G., Dini F., Effect of the bioactive metabolite euplotin C on phagocytosis and fluid-phase endocytosis in the single-celled eukaryote Paramecium, Aquatic Toxicology, 2007, 85, 67-75
20. Franceschi P., Guella G., Scarduelli G., Tosi P., Dilecce G., De Benedictis S., Chemical processes in the atmospheric pressure treatment of benzene. Plasma Processes and Polymers, 2007, 4, 548-555.
21. Guella G., Callone E., Di Giuseppe G., Frassanito R., Frontini F., Mancini I., Dini F., Hemivannusal and Prevannusadials, New Sesquiterpenoids from the Marine Ciliate Protist, Euplotes vannus. The Putative Biogenetic Precursors of Vannusals Dimeric Terpenoids. European Journal of Organic Chemistry, 2007, 31, 5226-5234
No projects are available to students for the current accademic year.