Girolama La Mantia
Girolama La Mantia
e-mail:
affiliation: Università di Napoli Federico II
research area(s): Molecular Biology, Cancer Biology
Course: Genetics and Molecular Medicine
University/Istitution: Università di Napoli Federico II
EDUCATION:
1972- degree in Biological Sciences (Naples) Final grade 110/110 cum laude

RESEARCH EXPERIENCE:
2000- Full Professor in Genetics-University of Naples Federico II. Director of the Department
of Structural and Functional Biology from 2008
Role of human tumor suppressor ARF in cell proliferation and senescence
Role of p63 in differentiation and cancer

1997-2000- Associate Professor in Genetics (Naples)
Role of human tumor suppressor ARF in cell proliferation and senescence

1989-1997- Associate Professor in Genetics (Naples)
Isolation and characterization of human endogenous retroviral sequences

1987-1992- Associate Professor in Genetics (Naples)
Isolation and characterization of zinc-finger coding genes in humans

1984-1987- Researcher at the Department of Genetics, General and Molecular Biology-Università
degli Studi di Napoli "Federico II". Naples (Italy)
Characterization of transactivating role of Polyoma and SV40 early
proteins

1982-83 Researcher at the Department of Genetics, General and Molecular Biology-Università
degli Studi di Napoli "Federico II". Naples (Italy)
Analysis of Pol II regulatory sequences

1981-82 Visiting fellow at the Imperial Cancer Research Fund in London
Regulation of Polyoma virus expression

1972-80- Fellow at the Zoological Station “Anton Dohrn (‘73-‘74) and Fellow at the International
Institute of Genetics and Biophysics (’75-’80).
Regulation of rDNA redundancy in D. melanogaster

1971-72 Undergraduate Student at the International Institute of Genetics and Biophysics
Regulation of gene expression in E.coliK12

TECHNICAL SKILLS AND COMPETENCES:
Competence in molecular genetics of cancer.
-Pollice, A., Nasti, V., Ronca, R., , Vivo, M., Lo Iacono, M., Calogero, R., Calabro`, V. & La
Mantia, G. Functional and Physical Interaction of the Human ARF TumorSuppressor with
Tat-binding Protein-1. J. Biol. Chem. 279, 6345-6353 (2004)
-Calabrò, V., Mansueto, G., Santoro, R., Gentilella, A., Pollice, A., Ghioni, P., Guerrini, L. &
La Mantia, G. Inhibition of p63 trascriptional activity by p14ARF: a functional and
physical link between human ARF tumor suppressor and a member of the p53 family”.
Mol. Cell. Biol. 24, 8529-40 (2004)
-Pollice, A. , Sepe, M., Villella, V.R., Tolino, F., Vivo, M., Calabrò, V. and La Mantia, G.
TBP-1 (Tat Binding Protein-1) protects the human oncosuppressor p14ARF from
proteasomal degradation. Oncogene. 26(35):5154-62 (2007)
-Amoresano A, Di Costanzo A, Leo G, Di Cunto F, La Mantia G, Guerrini L, Calabrò V
Identification of DeltaNp63alpha protein interactions by mass spectrometry.
J Proteome Res. 2010 Apr 5;9(4):2042-8
-Vivo M, Di Costanzo A, Fortugno P, Pollice A, Calabrò V, La Mantia G. Downregulation of
DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and
degradation. Cell Cycle. 8(21):3537-43 (2009)
-Galli, F.; Rossi, M.; D'Alessandra, Y.; De Simone, M.; Lopardo, T.; Haupt, Y.;
AlscheichBartok, O .; Anzi, S.; Shaulian, E.; Calabrò, V.; La Mantia G.; Guerrini, L.;
MDM2 and FBW7 cooperate to induce p63 protein degradation following DNA damage
and cell differentiation. Journal of Cell Science, 123:2423-33 (2010)
-Di Costanzo A, Festa L, Roscigno G, Vivo M, Pollice A, Morasso M, La Mantia G, Calabrò V. A dominant mutation etiologic for human tricho-dento-osseous syndrome impairs the ability of DLX3 to downregulate ΔNp63α.J Cell Physiol. 2011 Aug;226(8):2189-97. doi: 10.1002/jcp.22553
No projects are available to students for the current accademic year.