Tommaso Russo
Tommaso Russo
affiliation: Università di Napoli Federico II
research area(s): Molecular Biology, Experimental Medicine
Course: Genetics and Molecular Medicine
University/Istitution: Università di Napoli Federico II
M.D. degree in 1976, University of Naples. 1980-1987 Staff Researcher of the Italian National Research Council (CNR) - Special Project "CCN"; 1988-1990 Associate Professor, 2nd Medical School, University of Naples, Italy; 1990-1995 Professor of Biochemistry, School of Medicine, University of Naples "Federico II"; 1995-present Professor of Molecular Biology, School of Medicine, University of Naples "Federico II"; 1993 Guest Scientist, Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA; Starting from 1988, he obtained several research grants from Italian National Reserach Council, Special Project 'Ingegneria genetica', and from private (AIRC, Telethon) and public (ISS -AIDS project, CNR and MURST) Institutions. He was the coordinator of the "Grasping Alzheimer" project of the V Framework Project of the EC (2000-2003). He was responsible for one of the Research units of the APOPIS project of the VI Framework Project of the EC. He was also responsible for a research project funded by the Alzheimer's Association, USA (2004-2006). He is now responsible for one Research Units of the SIROCCO Consortium of the Framework Programme of the EC. Prof. Russo was a member of the Editorial Board of the Journal of Biological Chemistry from 2003 to 2008 and from 2010 to 2015.
The research activity of Dr Russo concerned with the study of: i) the structure and the functions of the molecular adaptor Fe65 and its partner APP and their role in the pathogenesis of Alzheimer's disease; ii) the effects of oxygen free radicals on the regulation of transcription and signal transduction; iii) gene regulation in embryonic cell differentiation.
Parisi S, Tarantino C, Paolella G, Russo T. (2010) A flexible method to study neuronal differentiation of mouse embryonic stem cells. Neurochem Res. 35(12):2218-25.

Silvia Parisi, Luca Cozzuto, Carolina Tarantino, Fabiana Passaro, Simona Ciriello, Luigi Aloia, Dario Antonini, Vincenzo De Simone, Lucio Pastore, Tommaso Russo (2010)Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state. BMC Biology , 8:128

Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24: 3255-63.

Aloia L, Parisi S, Fusco L, Pastore L, Russo T. (2010) Differentiation of embryonic stem cells 1 (Dies1) is a component of bone morphogenetic protein 4 (BMP4) signaling pathway required for proper differentiation of mouse embryonic stem cells. J Biol Chem. 285: 7776-83.

Stante M, Minopoli G, Passaro F, Raia M, Vecchio LD, Russo T. (2009) Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks. Proc Natl Acad Sci USA. 106:5093-8.

Ferrari-Toninelli G, Bonini SA, Uberti D, Napolitano F, Stante M, Santoro F, Minopoli G, Zambrano N, Russo T, Memo M. (2009) Notch activation induces neurite remodeling and functional modifications in SH-SY5Y neuronal cells. Dev Neurobiol. 69(6):378-391.

Zhou D, Zambrano N, Russo T, D'Adamio L. (2009) Phosphorylation of a Tyrosine in the Amyloid-beta Protein Precursor Intracellular Domain Inhibits Fe65 Binding and Signaling. J Alzheimers Dis. 16:301-7.

Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, Russo T. (2008) Klf5 is involved in self-renewal of mouse embryonic stem cells. J Cell Sci. 121:2629-34.

Napolitano F, D'Angelo F, Bimonte M, Perrina V, D'Ambrosio C, Scaloni A, Russo T, Zambrano N. (2008) A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse. Neurochem Res. 33(12):2547-55.

Minopoli G, Passaro F, Aloia L, Carlomagno F, Melillo RM, Santoro M, Forzati F, Zambrano N, Russo T. (2007) Receptor- and non-receptor tyrosine kinases induce processing of the amyloidprecursor protein: role of the low-density lipoprotein receptor-related protein. Neurodegener Dis. 4(2-3):94-100.

Nizzari M, Venezia V, Repetto E, Caorsi V, Magrassi R, Gagliani MC, Carlo P, Florio T, Schettini G, Tacchetti C, Russo T, Diaspro A, Russo C. (2007) Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 andmodulate ERK 1,2 signaling. J Biol Chem. 282(18):13833-44.

Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N. (2007) Identification of the ligands of protein interaction domains through a functional approach. Mol Cell Proteomics. 6(2):333-45.

Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T. (2007) Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem. 282(2):831-5.
Project Title:
Molecular mechanisms governing embryonic stem cell differentiation.

Project Title:
Fe65 in the response of the cells to DNA damage.