Juergen Borlak
e-mail: juergen.borlak AT item.fraunhofer.de
affiliation: Medical School of Hannover - Germany
research area(s): Experimental Medicine
Course:
Biomolecular Sciences
University/Istitution: Università di Trento
University/Istitution: Università di Trento
Present position
• Chair in Pharmaco- and Toxicogenomics, Medical School of Hannover, Germany
• Director, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany
• Member of the Executive Board of the Institute
Previous positions
- Department head, Molecular Medicine and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
- Section head - Preclinical Research - Pharmaceutical Industry, Germany.
- Senior Research Biochemist and Head, Unit of Pharmacogenetics, Marion Merrell Dow Research Centre, Strasbourg, France.
- Cancer Research Campaign funded Postdoctoral Research Fellow and Project Director, Molecular Oncology Group, University of Reading, United Kingdom.
Academic appointments
- C4 Professor and Chair in Pharmaco-and Toxicogenomics at the Medical School of Hannover, Germany.
- Professor for Molecular Anatomy at the Medical Faculty of the University Leipzig, Germany.
- Reader, Department of Medicine and Therapeutics and Department of Biomedical Sciences, University of Aberdeen, Scotland.
- Member of the Editorial Board of Mutation Research-Reviews, an International Journal for the entire spectrum of the science of mutation research and its applications Associate Editor of Toxicogenomics, an International Journal for Toxicogemonics of EHP, NIEHS, NIH.
- Associate Editor of Genes and Environment, the Official Journal of the Japanese Environmental Mutagen Society
- Member of the Editorial Board of Genome Medicine, an International Journal for all areas of medicine studied from a genomic or post-genomic perspective
- Member of the Editorial Board of Xenobiotica, an International Journal for General Xenobiochemistry and Molecular Toxicology
- Member of the Editorial Board of Proteomics Insights, an International Journal for all areas of proteomics
- Member of the Editorial Board of Journal of Integrative Bioinformatics, an International Journal for data integration, method integration and applications of theoretical/computational tools
- Member of the Editorial Board of the World Journal of Gastroenterology, an International journal in gastroenterology and hepatology
- Member of the Editorial Board of Frontiers in Predictive Toxicity a specialty section of Frontiers in Pharmacology, an International Journal for the entire research spectrum of pharmacology
- Reviewer for various scientific journals (e.g. The Lancet, Pharmacogenetics, Biochemical Pharmacology, Toxicology and Applied Pharmacology etc.)
- Appointed Expert by the World Health Organisation for Chemical and Drug Safety
- Member of the Council on Basic Cardiovascular Sciences for the American Stroke
Association
- Member of the drug discovery and development Industry Advisory Board
- Expert for the IMI Joint Undertaking (Innovative Medicines Initiative) under the responsibility of the European Commission for the evaluation of Expressions of Interest
Professional memberships
Biochemical Society
Royal Society of Chemistry
Society of Experimental Biology
International Society for the Study of Xenobiotics
Institute of Biology, UK
Society of Toxicology (SOT)
American Heart Association (AHA)
American Chemical Society (ACS)
American Stroke Association (ASA)
Japanese Society for Toxicology (JST)
University education
2003 Appointed as Professor at the Medical Faculty of the University Leipzig
2003 C4-Professor and chair in pharmaco- and toxicogenomics at the Medical School of Hannover
2000 Habilitation and venia legendi in pharmacology and toxicology at the Medical School of Hannover.
1989 Ph.D. in biochemistry and biochemical toxicology. Thesis title: "Comparative Studies on the Biochemical Toxicology of Polychlorinated Biphenyls (PCBs).
1985 - 1989 Department of Biochemistry and Physiology, University of Reading. Full-time postgraduate Ph.D. program. Supported by Ernest Ridley Postgraduate Fellowship of the University of Reading (competitive basis).
1985 Awarded M.Sc. Thesis title: "Some characteristics of the enzyme converting 1-Aminocyclopropane-1-carboxylic acid to ethylene".
1984 - 1985 University of Reading. Full-time postgraduate student. Supported by a German Postgraduate Award (competitive) of the German Academic Exchange Service (DAAD).
1983 - 1984 One-year qualifying research thesis for the degree, Supported financially by Deutsche Forschungsgemeinschaft. Thesis title: "Analytik und Toxikologie halogenierter Phenolcarbonsäuren
mit natürlichem Vorkommen unter besonderer Berücksichtigung der 4-Hyroxyzimtsäure und ihren Derivaten". Teil 1: Analytik, Teil 2: Toxikologie
1978 - 1983 Undergraduate education, First class
• Chair in Pharmaco- and Toxicogenomics, Medical School of Hannover, Germany
• Director, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany
• Member of the Executive Board of the Institute
Previous positions
- Department head, Molecular Medicine and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
- Section head - Preclinical Research - Pharmaceutical Industry, Germany.
- Senior Research Biochemist and Head, Unit of Pharmacogenetics, Marion Merrell Dow Research Centre, Strasbourg, France.
- Cancer Research Campaign funded Postdoctoral Research Fellow and Project Director, Molecular Oncology Group, University of Reading, United Kingdom.
Academic appointments
- C4 Professor and Chair in Pharmaco-and Toxicogenomics at the Medical School of Hannover, Germany.
- Professor for Molecular Anatomy at the Medical Faculty of the University Leipzig, Germany.
- Reader, Department of Medicine and Therapeutics and Department of Biomedical Sciences, University of Aberdeen, Scotland.
- Member of the Editorial Board of Mutation Research-Reviews, an International Journal for the entire spectrum of the science of mutation research and its applications Associate Editor of Toxicogenomics, an International Journal for Toxicogemonics of EHP, NIEHS, NIH.
- Associate Editor of Genes and Environment, the Official Journal of the Japanese Environmental Mutagen Society
- Member of the Editorial Board of Genome Medicine, an International Journal for all areas of medicine studied from a genomic or post-genomic perspective
- Member of the Editorial Board of Xenobiotica, an International Journal for General Xenobiochemistry and Molecular Toxicology
- Member of the Editorial Board of Proteomics Insights, an International Journal for all areas of proteomics
- Member of the Editorial Board of Journal of Integrative Bioinformatics, an International Journal for data integration, method integration and applications of theoretical/computational tools
- Member of the Editorial Board of the World Journal of Gastroenterology, an International journal in gastroenterology and hepatology
- Member of the Editorial Board of Frontiers in Predictive Toxicity a specialty section of Frontiers in Pharmacology, an International Journal for the entire research spectrum of pharmacology
- Reviewer for various scientific journals (e.g. The Lancet, Pharmacogenetics, Biochemical Pharmacology, Toxicology and Applied Pharmacology etc.)
- Appointed Expert by the World Health Organisation for Chemical and Drug Safety
- Member of the Council on Basic Cardiovascular Sciences for the American Stroke
Association
- Member of the drug discovery and development Industry Advisory Board
- Expert for the IMI Joint Undertaking (Innovative Medicines Initiative) under the responsibility of the European Commission for the evaluation of Expressions of Interest
Professional memberships
Biochemical Society
Royal Society of Chemistry
Society of Experimental Biology
International Society for the Study of Xenobiotics
Institute of Biology, UK
Society of Toxicology (SOT)
American Heart Association (AHA)
American Chemical Society (ACS)
American Stroke Association (ASA)
Japanese Society for Toxicology (JST)
University education
2003 Appointed as Professor at the Medical Faculty of the University Leipzig
2003 C4-Professor and chair in pharmaco- and toxicogenomics at the Medical School of Hannover
2000 Habilitation and venia legendi in pharmacology and toxicology at the Medical School of Hannover.
1989 Ph.D. in biochemistry and biochemical toxicology. Thesis title: "Comparative Studies on the Biochemical Toxicology of Polychlorinated Biphenyls (PCBs).
1985 - 1989 Department of Biochemistry and Physiology, University of Reading. Full-time postgraduate Ph.D. program. Supported by Ernest Ridley Postgraduate Fellowship of the University of Reading (competitive basis).
1985 Awarded M.Sc. Thesis title: "Some characteristics of the enzyme converting 1-Aminocyclopropane-1-carboxylic acid to ethylene".
1984 - 1985 University of Reading. Full-time postgraduate student. Supported by a German Postgraduate Award (competitive) of the German Academic Exchange Service (DAAD).
1983 - 1984 One-year qualifying research thesis for the degree, Supported financially by Deutsche Forschungsgemeinschaft. Thesis title: "Analytik und Toxikologie halogenierter Phenolcarbonsäuren
mit natürlichem Vorkommen unter besonderer Berücksichtigung der 4-Hyroxyzimtsäure und ihren Derivaten". Teil 1: Analytik, Teil 2: Toxikologie
1978 - 1983 Undergraduate education, First class
.
Lehner, F., Kulik, U., Klempnauer, J. and Borlak, J. (2010) Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells (PloS ONE, accepted for publication)
Garaguso, I., Halter, R., Krzeminski, J., Amin, S. and Borlak, J. (2010) A Method for Rapid Detection and Molecular Characterization of DNA Alkylating Agents by MALDI-TOF Mass Spectrometry (Analytical Chemistry, accepted for publication)
Rodt, T., Luebke, M., Boehm, C., von Falck, C., Stamm, G., Borlak, J., Seifert, H. and Galanski, M. (2010). Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice (Acta Radiologica, accepted for publication)
Rohrbeck, A., Salinas, G., Maaser, K., Linge, J., Salovaara, S., Corvi, R and Borlak, J. (2010) Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens. Toxicological Sciences [Epub ahead of print]
Reamon-Buettner, S.M. and Juergen Borlak (2010) NKX2-5: An Update on this Hypermutable Homeodomain Protein and its Role in Human Congenital Heart Disease (CHD). Human Mutation [Epub ahead of print]
Reamon-Buettner, S.M. and Juergen Borlak (2010) Commentary on investigations of somatic NKX2-5 mutations in congenital heart disease (CHD). Journal of Medical Genetics, eletter published online July 9, 2010
Thum, T., Batkai, S., Malinski, P.G., Becker, T., Mevius, I., Klempnauer, J., Meyer, H.H., Frölich, J.C., Borlak, J. and Tsikas, D. (2010) Measurement and diagnostic use of hepatic CYP450 metabolism of oleic acid in human liver disease. Liver International. 30:1181-8
Fritzinger, D.C., Dean R., Meschter C., Wong A.K., Halter R., Borlak J., St. John W.D. and Vogel C.-W. (2010). Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-related Macular Degeneration. Advances in Experimental Medicine and Biology. 703:151-62
Harush-Frenkel, O., Bivas Benita, M., Nassar, T., Springer, C., Sherman, Y., Avital, A., Altschuler, Y, Borlak, J. and Benita, S. (2010) A safety and tolerability study of differently charged nanoparticles for local pulmonary drug delivery Toxicology and Applied Pharmacology. 246:83-90
Lehner, F., Kulik, U., Klempnauer, J. and Borlak, J. (2010) Mapping of liver-enriched transcription factors in the human intestine. World Journal of Gastroenterology. 16:3919-27
Zwadlo, C. and Borlak, J. (2009) Impaired Tissue Clearance of Verapamil in Rat Cardiac Hypertrophy Results in Transcriptional Repression of Ion Channels. Xenobiotica. Xenobiotica. 40:291-9
Passarella, D., Peretto, B., Blasco, R, Cappelletti, G., Cartelli, D., Ronchi, C., Snaith, J., Fontana, G., Danieli, B. and Jurgen Borlak, J. (2009) Synthesis and Biological Evaluation of Novel Thiocolchicine-Podophyllotoxin Conjugates. European Journal of Medicinal Chemistry. 45:219-26
Passarella, D., Comi, D., Cappelletti, G., Borlak, J., Quesada, A and Altmann, K.-H. (2009) Synthesis and Biological Evaluation of Epothilone A Dimeric Compounds. Bioorganic & Medicinal Chemistry. 17:7435-40
Rohrbeck, A. and Borlak, J. (2009) Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PLoS One. 4:e7315.
Gazzana, G. and Borlak, J. (2009) An update on the mouse liver proteome. Proteome Science. 7:35.
Borlak, J. (2009) 3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity. Human & Experimental Toxicology. 28:119–121.
Långström, B., Grahnen, A., Honoré, P.H., Borlak, J., Bergstrom, M., Nielsen, B., Vanderheyden, J., Watanabe, Y., Josephsson, R., Høilund-Carlsen, P.F., Schwaiger, M., Larson, S.M., Goldenberg, D.M., Melzer, A., Engler, H., Hicks, R., Sundin, A., Seppänen, M., Hedenstierna, G., Nordberg, A. and Brooks D. (2009) The risk of exaggerated risk aversion-a life and death struggle for molecular imaging. European journal of nuclear medicine and molecular imaging. 36(10):1693-4.
Reamon-Buettner, S.M., Ciribilli, Y, Traverso, I, Kuhls, B, Inga, A and Borlak, J (2009) A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Human Molecular Genetics. 18:3567-78.
Nowicki, M., Kosacka, J., Spanel-Borowski, K. and Borlak, J. (2009) Deferoxamine induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures. European Journal of Cell Biology. 88:551-62
Kosacka, J., Gericke, M., Nowicki, M., Kacza, J., Borlak, J. and Spanel-Borowski, K. (2009) Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. Neuroscience. 162(2):282-291.
Garaguso, I., Halter, R., Krzeminski, J., Amin, S. and Borlak, J. (2010) A Method for Rapid Detection and Molecular Characterization of DNA Alkylating Agents by MALDI-TOF Mass Spectrometry (Analytical Chemistry, accepted for publication)
Rodt, T., Luebke, M., Boehm, C., von Falck, C., Stamm, G., Borlak, J., Seifert, H. and Galanski, M. (2010). Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice (Acta Radiologica, accepted for publication)
Rohrbeck, A., Salinas, G., Maaser, K., Linge, J., Salovaara, S., Corvi, R and Borlak, J. (2010) Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens. Toxicological Sciences [Epub ahead of print]
Reamon-Buettner, S.M. and Juergen Borlak (2010) NKX2-5: An Update on this Hypermutable Homeodomain Protein and its Role in Human Congenital Heart Disease (CHD). Human Mutation [Epub ahead of print]
Reamon-Buettner, S.M. and Juergen Borlak (2010) Commentary on investigations of somatic NKX2-5 mutations in congenital heart disease (CHD). Journal of Medical Genetics, eletter published online July 9, 2010
Thum, T., Batkai, S., Malinski, P.G., Becker, T., Mevius, I., Klempnauer, J., Meyer, H.H., Frölich, J.C., Borlak, J. and Tsikas, D. (2010) Measurement and diagnostic use of hepatic CYP450 metabolism of oleic acid in human liver disease. Liver International. 30:1181-8
Fritzinger, D.C., Dean R., Meschter C., Wong A.K., Halter R., Borlak J., St. John W.D. and Vogel C.-W. (2010). Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-related Macular Degeneration. Advances in Experimental Medicine and Biology. 703:151-62
Harush-Frenkel, O., Bivas Benita, M., Nassar, T., Springer, C., Sherman, Y., Avital, A., Altschuler, Y, Borlak, J. and Benita, S. (2010) A safety and tolerability study of differently charged nanoparticles for local pulmonary drug delivery Toxicology and Applied Pharmacology. 246:83-90
Lehner, F., Kulik, U., Klempnauer, J. and Borlak, J. (2010) Mapping of liver-enriched transcription factors in the human intestine. World Journal of Gastroenterology. 16:3919-27
Zwadlo, C. and Borlak, J. (2009) Impaired Tissue Clearance of Verapamil in Rat Cardiac Hypertrophy Results in Transcriptional Repression of Ion Channels. Xenobiotica. Xenobiotica. 40:291-9
Passarella, D., Peretto, B., Blasco, R, Cappelletti, G., Cartelli, D., Ronchi, C., Snaith, J., Fontana, G., Danieli, B. and Jurgen Borlak, J. (2009) Synthesis and Biological Evaluation of Novel Thiocolchicine-Podophyllotoxin Conjugates. European Journal of Medicinal Chemistry. 45:219-26
Passarella, D., Comi, D., Cappelletti, G., Borlak, J., Quesada, A and Altmann, K.-H. (2009) Synthesis and Biological Evaluation of Epothilone A Dimeric Compounds. Bioorganic & Medicinal Chemistry. 17:7435-40
Rohrbeck, A. and Borlak, J. (2009) Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PLoS One. 4:e7315.
Gazzana, G. and Borlak, J. (2009) An update on the mouse liver proteome. Proteome Science. 7:35.
Borlak, J. (2009) 3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity. Human & Experimental Toxicology. 28:119–121.
Långström, B., Grahnen, A., Honoré, P.H., Borlak, J., Bergstrom, M., Nielsen, B., Vanderheyden, J., Watanabe, Y., Josephsson, R., Høilund-Carlsen, P.F., Schwaiger, M., Larson, S.M., Goldenberg, D.M., Melzer, A., Engler, H., Hicks, R., Sundin, A., Seppänen, M., Hedenstierna, G., Nordberg, A. and Brooks D. (2009) The risk of exaggerated risk aversion-a life and death struggle for molecular imaging. European journal of nuclear medicine and molecular imaging. 36(10):1693-4.
Reamon-Buettner, S.M., Ciribilli, Y, Traverso, I, Kuhls, B, Inga, A and Borlak, J (2009) A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Human Molecular Genetics. 18:3567-78.
Nowicki, M., Kosacka, J., Spanel-Borowski, K. and Borlak, J. (2009) Deferoxamine induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures. European Journal of Cell Biology. 88:551-62
Kosacka, J., Gericke, M., Nowicki, M., Kacza, J., Borlak, J. and Spanel-Borowski, K. (2009) Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. Neuroscience. 162(2):282-291.
No projects are available to students for the current accademic year.