Lucia Sacchetti
Lucia Sacchetti
affiliation: Università di Napoli Federico II
research area(s): Genetics And Genomics, Molecular Biology
Course: Genetics and Molecular Medicine
University/Istitution: Università di Napoli Federico II
She graduated in biology in 1972 and obtained her post-graduate specialization in microbiology from the University of Naples Federico II. In 1980 she was appointed Associate Professor of Clinical Biochemistry, School of Medicine, University of Naples Federico II. Since 1990 she is Professor of Clinical Biochemistry at the University of Naples Federico II and works in the Department of Biochemistry and Medical Biotechnologies (DBBM). Since 1984 she is Biology Director at the Department of Laboratory Medicine of the University Hospital Federico II, and manages the Functional Area of Biological Individuality. Since 2004 she is Director of an operative unit at CEINGE (Advanced Biotechnologies), a research center that works by an agreement with DBBM. Since 2008 (before from 2000 to 2006) she is Director of the Postgraduate School of Clinical Biochemistry, School of Medicine, University of Naples Federico II.

Teaching activities:
She teaches within the framework of Laboratory Medicine, in the Medical degree course and in the Degree Course (Level 1) "Biomedical Laboratory Technician" and "Pediatric Nurse", School of Medicine, University of Naples Federico II. She is on the faculty of the doctorate programme in Genetics and Molecular Medicine. She also teaches in several post-graduate programmes: Clinical Biochemistry, Hygiene, Pediatrics, Genetics. At the School of Medicine, University of Naples Federico II, she taught Systemic Human Biochemistry (1984-1987), Cellular Biochemistry (1991-1995) in the Medical degree course; Clinical Biochemistry and Clinical Molecular Biology (2002-2003) in the degree course in Biotechnologies; and Laboratory Diagnostics (2002-2009) in the degree course in Dentistry.

Prof. Sacchetti published over 120 original articles, most of which in peer-reviewed journals (I.F. > 350). She presented over 200 communications to national and international scientific conferences.
Selection of books edited: Medicina di Laboratorio e Diagnostica Genetica - (E. Sorbona, 2007); "Medicina di Laboratorio" (UTET, 1996); Clinical Biochemistry in Hepatobiliary Diseases (1988 Springer Verlag, Heidelberg, Vol. 8)
(1) Experimental and laboratory hematology; (2) Physiopathological studies on biochemical markers (for tumors and isoenzyme systems); (3) Analytical clinical biochemistry (new methods, reference values and statistical evaluation of laboratory data); (4) Clinical diagnostics and individual typing using recombinant DNA; (5) Gene polymorphisms, mutations, gene expression products, regulation of gene expression and biochemical parameters associated with: oxidative based diseases (e.g., cardiovascular diseases, acquired deafness, age-related macular degeneration, etc.), neoplasias, celiac disease and obesity; (6) Evaluation of polymorphisms, mutations in key genes for drug responses; (7) Mutations associated with monogenic diabetes.
1) R. Di Noto, P. Mirabelli, E. Mariotti, L. Sacchetti, F, Pane, B. Rotoli, C.L. Pardo, L. Del Vecchio, C. Mecucci, F. Salvatore (2006) CMRL-T, a novel T-cell line showing asynchronous phenotype (CD34+/CD1a-/TCRalphabeta+) and dual T-cell receptor beta chain. Leukemia 20(12), 2175-2177.

2) R. Bracale, F. Pasanisi, G. Labruna, C. Finelli, C. Nardelli, P. Buono, G. Salvatori, L. Sacchetti, F. Contaldo, G. Oriani (2007) Metabolic sindrome and ADRB3 gene polymorphism in severely obese patients from South Italy. European Journal of Clinical Nutrition 61(10), 1213-1219.

3) M. Bourgey, G. Calcagno, N. Tinto, D. Gennarelli, P. Margaritte-Jeannin, L. Greco, M.G. Limongelli, O. Esposito, C. Marano, R. Troncone, A. Spampanato, F. Clerget-Darpoux, L. Sacchetti (2007) HLA related genetic risk for coeliac disease. Gut 56(8), 1054-1059.

4) N. Tinto, C. Ciacci, G. Calcagno, D. Gennarelli, A. Spampanato, E. Farinaro, R. Tortora, L. Sacchetti (2008) Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous subjects from the Campania area. Digestive and Liver Disease 40(4):248-252.

5) G.Fortunato, G. Calcagno, V.Bresciamorra, E.Salvatore, A. Filla, S. Capone,R. Liguori, S. Borelli, I. Gentile. F. Borrelli, G. Borgia, L. Sacchetti (2008) Multiple sclerosis and hepatitis C virus infection are associated with single nucleotide polymorphisms in interferon pathway genes. Journal of Interferon & Cytokine Research 28:141-152.

6) N.Tinto, A.Zagari, M.Capuano, A. De Simone, V. Capobianco, G.Daniele, M.Giugliano, R.Spadaro, A.Franzese, L.Sacchetti (2008) Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy. PLoS One 3(4):e1870.

7) C.Mazzaccara, G.Labruna, G.Cito, M.Scarfò, M.De Felice, L.Pastore, L.Sacchetti (2008) Age-related reference intervals of the main biochemical and hematological parameters in C57BL/6J, 129SV/EV and C3H/HeJ mouse strains. PloS One 3 (11): e3772.

8) G. Borgia, I.Gentile, G.Fortunato, F.Borrelli, S.Borelli, Caterina, MD.Di Taranto, M.Simome, F.Borgia, C.Viola, L.Reynaud, R.Cerini, L.Sacchetti (2009) Homocysteine levels and sustained virological response to pegylated-interferon alpha2b plus ribavirin therapy for chronic hepatitis C: a prospective study. Liver International 29(2): 248-52.

9) O.Fattoruso, S.Zarrilli, I.Coto, M.De Rosa, G. Lombardi, L. Sacchetti (2009) Prevalence of Y microdeletion in azoospermic and severe oligozoospermic men in Southern Italy: application of a rapid capillary elctrophoresis method. Journal of Endocrinology Investigation 32(3): 223-7.

10) G.Labruna, F. Pasanisi, C.Nardelli, G. Tarantino, D.F. Vitale, R. Bracale, C.Finelli, M.P.Genua, G. Contaldo, L. Sacchetti (2009) UCP1-3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity. Journal of Endocrinology Investigation 32(6): 525-9.

11) V. D'Antò, A. Michelotti, L. Esposito, A. Zagari, R. Liguori, L. Sacchetti (2010) Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder. Progress in Orthodontics 11: 174-9.

12) G. Calcagno, A. Staiano, G. Fortunato, V. Bresciamorra, E. Salvatore, R. Liguori, S.Capone, A. Filla, G. Longo, L. Sacchetti (2010) A multilayer perceptron neural network-based approach for the identification of responsiveness to interferon therapy in multiple sclerosis patients. Informations Science 180: 4153-63.

13) A. Alfieri, F. Pasanisi, S. salzano, L. Esposito, D. Martone, D. Tafuri, A. Daniele, F. Contaldo, L. Sacchetti, A. Zagari, P. Buono (2010) Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy. Gene 457: 35-41.

14) R. Martinelli, C. Nardelli, V. Pilone, T. Buonomo, R. Liguori, I. Castanò, P. Buono, S. Masone, G. Persico, P. Forestieri, L. Pastore, L. Sacchetti (2010) miR-519d overexpression is associated with human obesity. Obesity 18: 2170-76.

15) G.Labruna, F. Pasanisi, C. Nardelli, R. Caso, D.F.Vitale, F. Contaldo, L. Sacchetti (2010) High Leptin/adiponectin ratio and serum triglicerides are associated with an at-risk phenotype in young severely obese patients. Obesity Doi: 10.1038/oby.2010.309.

16) C.V.Musa, A. Mancini, A.Alfieri, G.Labruna, G. Valerio, A.Franzese, F. Pasanisi, M.R. Licenziati, L. Sacchetti, P. Buono (2011) Four novel UCP3 gene variants associated to childhood obesity: effect on fatty acid oxidation and on prevention of trigliceride storage. International Journal Obesity 1-11.

17) G. Labruna, F. Pasanisi, G. Fortunato, C. Nardelli, C. Finelli, E. Farinaro, F. Contaldo, L. Sacchetti (2011) Sequence analysis of the UCP1 gene in a severe obese population from Southern Italy. Journal of Obesity ID 269043
Project Title:
miRNA based regulation of gene expression in small intestine from celiac patients.

Project Title:
Characterization of amniotic stem cells from obese pregnant women.