Paolo Paolucci
e-mail: paolo.paolucci AT unimore.it
affiliation: Università di Modena-Reggio Emilia
research area(s): Experimental Medicine, Stem Cells And Regenerative Medicine
Course:
Molecular and Regenerative Medicine
University/Istitution: Università di Modena-Reggio Emilia
University/Istitution: Università di Modena-Reggio Emilia
Present Professional Positions at the University of Modena and Reggio Emilia (U-MORE)
• Director of the Department of Mother and Child, Azienda Ospedaliero-Universitaria di Modena (AOU-MO) (since 01/01/04);
• Director of the Unit of Hematology, Oncology, Immunology and Cell Therapy (since 01/11/02);
• Director of the Unit of Paediatrics (since 01/11/09);
• Professor of Paediatrics, U-MORE (2002-05);
• Full Professor of Paediatrics, U-MORE (2005-11);
• Teacher at the post-graduate Schools of Paediatrics, Paediatric NeuroPsychiatry, Haematology and Doctorate in Molecular and Riparative Medicine, U-MORE (2005-11).
Previous Professional Positions
Teaching and research experience
1972-74 Fellowship in Paediatrics, University of Bologna (U-BO);
1974-80 Research Fellow at the Paediatric Clinic, U-BO;
1978-79 Research Fellow at the Institute of Child Health, University of London (UK);
1980-85 Researcher at the Paediatric Clinic, U-BO;
e. 1984 Research Fellow at St.Jude Children’s Research Hospital, Memphis, University of Tennessee (USA);
1985-93 Associate Professor of Paediatrics at the Paediatric Clinic, U-BO;
2003-05 Director of the II level Master in “Paediatric Haematology and Oncology”, U-MORE;
2003-08 Director of the post-graduate School of Paediatrics, U-MORE
2005-10 Chairman of the TEG in Oncology of the FP6 “TEDDY (Task Force in Europe for Drug Development for the Young) project”.
Clinical Experience
1985-1993 Head of the Bone Marrow Transplantation Unit at the Paediatric Clinic, U-BO;
b. 1993-1996 Head of the Unit of Paediatrics at the Hospital of Lugo (RA);
c. 1996-2002 Head of the Department of Paediatrics at the I.R.C.C.S. “Casa Sollievo della Sofferenza Hospital”, San Giovanni Rotondo (FG).
Additional Appointments
1979-1985 Head of the Laboratory of Immunology at the Paediatric Clinic, U-BO;
1985-1993 Head of the Laboratory of Cytogenetics and Cell Biology at the Paediatric Clinic, U-BO;
1986-1988 Founder and Chairman of the Italian Study Group for Bone Marrow Transplantation of the Italian Association of Paediatric Haematology and Oncology (AIEOP);
1986-1995 Founder and Chairman of the Italian Registry of Bone Marrow Transplantation of the AIEOP (first paediatric registry in the world);
e. 1996 Founder and Member of the Working Party “Paediatric Diseases”, European Blood and Bone Marrow Transplantation Group (EBMT)
2008-2011 Member as Health Professional of the Paediatric Committee (PDCO) at European Medicines Agency (EMA).
• Director of the Department of Mother and Child, Azienda Ospedaliero-Universitaria di Modena (AOU-MO) (since 01/01/04);
• Director of the Unit of Hematology, Oncology, Immunology and Cell Therapy (since 01/11/02);
• Director of the Unit of Paediatrics (since 01/11/09);
• Professor of Paediatrics, U-MORE (2002-05);
• Full Professor of Paediatrics, U-MORE (2005-11);
• Teacher at the post-graduate Schools of Paediatrics, Paediatric NeuroPsychiatry, Haematology and Doctorate in Molecular and Riparative Medicine, U-MORE (2005-11).
Previous Professional Positions
Teaching and research experience
1972-74 Fellowship in Paediatrics, University of Bologna (U-BO);
1974-80 Research Fellow at the Paediatric Clinic, U-BO;
1978-79 Research Fellow at the Institute of Child Health, University of London (UK);
1980-85 Researcher at the Paediatric Clinic, U-BO;
e. 1984 Research Fellow at St.Jude Children’s Research Hospital, Memphis, University of Tennessee (USA);
1985-93 Associate Professor of Paediatrics at the Paediatric Clinic, U-BO;
2003-05 Director of the II level Master in “Paediatric Haematology and Oncology”, U-MORE;
2003-08 Director of the post-graduate School of Paediatrics, U-MORE
2005-10 Chairman of the TEG in Oncology of the FP6 “TEDDY (Task Force in Europe for Drug Development for the Young) project”.
Clinical Experience
1985-1993 Head of the Bone Marrow Transplantation Unit at the Paediatric Clinic, U-BO;
b. 1993-1996 Head of the Unit of Paediatrics at the Hospital of Lugo (RA);
c. 1996-2002 Head of the Department of Paediatrics at the I.R.C.C.S. “Casa Sollievo della Sofferenza Hospital”, San Giovanni Rotondo (FG).
Additional Appointments
1979-1985 Head of the Laboratory of Immunology at the Paediatric Clinic, U-BO;
1985-1993 Head of the Laboratory of Cytogenetics and Cell Biology at the Paediatric Clinic, U-BO;
1986-1988 Founder and Chairman of the Italian Study Group for Bone Marrow Transplantation of the Italian Association of Paediatric Haematology and Oncology (AIEOP);
1986-1995 Founder and Chairman of the Italian Registry of Bone Marrow Transplantation of the AIEOP (first paediatric registry in the world);
e. 1996 Founder and Member of the Working Party “Paediatric Diseases”, European Blood and Bone Marrow Transplantation Group (EBMT)
2008-2011 Member as Health Professional of the Paediatric Committee (PDCO) at European Medicines Agency (EMA).
Principal Fields of Scientific Interest
1. Cellular and molecular basis of congenital defects of immunity;
2. Cellular and molecular basis of paediatric cancer;
3. Clinical trials development in Paediatric Haematology and Oncology;
4. Gene expression profiling and pharmacogenetics;
5. Cell therapies in paediatric haematology and oncology;
6. Clinical trials in paediatric oncology and long term effects of oncological therapies;
Development and application of epithelial and mesenchymal stem cells in paediatric diseases.
1. Cellular and molecular basis of congenital defects of immunity;
2. Cellular and molecular basis of paediatric cancer;
3. Clinical trials development in Paediatric Haematology and Oncology;
4. Gene expression profiling and pharmacogenetics;
5. Cell therapies in paediatric haematology and oncology;
6. Clinical trials in paediatric oncology and long term effects of oncological therapies;
Development and application of epithelial and mesenchymal stem cells in paediatric diseases.
1. Lanciotti M, D'Apolito M, Paolucci P, Indaco S, Dufour C. (2011) Gene expression profiling: a possible tool in the prediction of outcome in paediatric acute lymphoblastic leukaemia ? Br J Haematol. 153: 273-85.
2. Granchi D, Corrias MV, Garaventa A, Baglìo SR, Cangemi G, Carlini B, Paolucci P, Giunti A, Baldini N. (2011) Neuroblastoma and bone metastases: clinical significance and prognostic value of Dickkopf 1 plasma levels. Bone. 48: 152-9.
3. Russo R, Capasso M, Paolucci P, Iolascon A. (2011) Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives. Eur J Clin Pharmacol. 67 Suppl:17-27.
4. Paolucci P, Cioni V, Bigi E, Lucaccioni L, Cano C. (2011) Endpoints in Paediatric Oncology. Eur J Clin Pharmacol; 67 Suppl: 33-40.
5. Grisendi G, Annerén C, Cafarelli L, Sternieri R, Veronesi E, Cervo GL, Luminari S, Maur M, Frassoldati A, Palazzi G, Otsuru S, Paolucci P, Conte PF, Horwitz EM, Dominici M. (2010) GMP-Manufactured Density Gradient Media for Optimized Mesenchymal Stromal/Stem Cells Isolation and Expansion. Cytotherapy. 12:466-77.
6. Malagoli C, Fabbi S, Teggi S, Calzari M, Poli M, Ballotti E, Notari B, Bruni M, Palazzi G, Paolucci P, Vinceti M. (2010) Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy. Environ Health. 30;9:16.
7. Grisendi G, Bussolari R, Cafarelli L, Petak I, Rasini V, Veronesi E, De Santis G, Spano C, Tagliazzucchi M, Barti-Juhasz H, Scarabelli L, Bambi F, Frassoldati A, Rossi G, Casali C, Morandi U, Horwitz EM, Paolucci P, Conte P, Dominici M. (2010) Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy. Cancer Res. 70:3718-29.
8. Rocchi F, Paolucci P, Ceci A, Rossi P. (2010) The European paediatric legislation: benefits and perspectives. Ital J Pediatr. Aug 17;36:56.
9. Potenza L, Barozzi P, Rossi G, Palazzi G, Vallerini D, Riva G, Cellini M, Morselli M, Volzone F, Venturelli C, Quadrelli C, Di Pancrazio L, Cano MC, Paolucci P, Torelli G, Luppi M. (2008) Assessment of aspergillus-specific T cells for diagnosis of invasive aspergillosis in a leukemic child with liver lesions mimicking hepatosplenic candidiasis. Clin Vaccine Immunol. 15: 1625-28.
10. Dominici M, Rasini V, Bussolari R, Chen X, Hofmann TJ, Spano C, Bernabei D, Veronesi E, Bertoni F, Paolucci P, Conte P, Horwitz EM. (2009) Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood114: 2333-43.
11. Dominici M, Paolucci P, Conte PF, Horwitz EM. (2009) Heterogeneity of Multipotent Mesenchymal Stromal Cells: From Stromal Cells to Stem Cells and Vice Versa. Transplantation. 2009; 87: 36-42.
12. Paolucci P, Jones KP, del Carmen Cano, Garcinuno M, Catalano M, Iolascon A, A.Ceci A. (2008) Challanges in drug prescribing for children with cancer. Lancet Oncol. 9: 176-183.
13. Dominici M, Marino R, Rasini V, Spano C, Paolucci P, Conte PF, Hofmann TJ, Horwitz EM. (2008) Donor cell-derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation. Blood; 111: 4386-91.
14.Chiappini E, Galli L, Cellini M, Cano MC, Paolucci P et al for The Italian Register for HIV Infection in Children (2007) Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: a study by the Italian Register for HIV Infection in Children. J Clin Oncol; 25: 97-101.
2. Granchi D, Corrias MV, Garaventa A, Baglìo SR, Cangemi G, Carlini B, Paolucci P, Giunti A, Baldini N. (2011) Neuroblastoma and bone metastases: clinical significance and prognostic value of Dickkopf 1 plasma levels. Bone. 48: 152-9.
3. Russo R, Capasso M, Paolucci P, Iolascon A. (2011) Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives. Eur J Clin Pharmacol. 67 Suppl:17-27.
4. Paolucci P, Cioni V, Bigi E, Lucaccioni L, Cano C. (2011) Endpoints in Paediatric Oncology. Eur J Clin Pharmacol; 67 Suppl: 33-40.
5. Grisendi G, Annerén C, Cafarelli L, Sternieri R, Veronesi E, Cervo GL, Luminari S, Maur M, Frassoldati A, Palazzi G, Otsuru S, Paolucci P, Conte PF, Horwitz EM, Dominici M. (2010) GMP-Manufactured Density Gradient Media for Optimized Mesenchymal Stromal/Stem Cells Isolation and Expansion. Cytotherapy. 12:466-77.
6. Malagoli C, Fabbi S, Teggi S, Calzari M, Poli M, Ballotti E, Notari B, Bruni M, Palazzi G, Paolucci P, Vinceti M. (2010) Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy. Environ Health. 30;9:16.
7. Grisendi G, Bussolari R, Cafarelli L, Petak I, Rasini V, Veronesi E, De Santis G, Spano C, Tagliazzucchi M, Barti-Juhasz H, Scarabelli L, Bambi F, Frassoldati A, Rossi G, Casali C, Morandi U, Horwitz EM, Paolucci P, Conte P, Dominici M. (2010) Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy. Cancer Res. 70:3718-29.
8. Rocchi F, Paolucci P, Ceci A, Rossi P. (2010) The European paediatric legislation: benefits and perspectives. Ital J Pediatr. Aug 17;36:56.
9. Potenza L, Barozzi P, Rossi G, Palazzi G, Vallerini D, Riva G, Cellini M, Morselli M, Volzone F, Venturelli C, Quadrelli C, Di Pancrazio L, Cano MC, Paolucci P, Torelli G, Luppi M. (2008) Assessment of aspergillus-specific T cells for diagnosis of invasive aspergillosis in a leukemic child with liver lesions mimicking hepatosplenic candidiasis. Clin Vaccine Immunol. 15: 1625-28.
10. Dominici M, Rasini V, Bussolari R, Chen X, Hofmann TJ, Spano C, Bernabei D, Veronesi E, Bertoni F, Paolucci P, Conte P, Horwitz EM. (2009) Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood114: 2333-43.
11. Dominici M, Paolucci P, Conte PF, Horwitz EM. (2009) Heterogeneity of Multipotent Mesenchymal Stromal Cells: From Stromal Cells to Stem Cells and Vice Versa. Transplantation. 2009; 87: 36-42.
12. Paolucci P, Jones KP, del Carmen Cano, Garcinuno M, Catalano M, Iolascon A, A.Ceci A. (2008) Challanges in drug prescribing for children with cancer. Lancet Oncol. 9: 176-183.
13. Dominici M, Marino R, Rasini V, Spano C, Paolucci P, Conte PF, Hofmann TJ, Horwitz EM. (2008) Donor cell-derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation. Blood; 111: 4386-91.
14.Chiappini E, Galli L, Cellini M, Cano MC, Paolucci P et al for The Italian Register for HIV Infection in Children (2007) Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: a study by the Italian Register for HIV Infection in Children. J Clin Oncol; 25: 97-101.
No projects are available to students for the current accademic year.