Giuseppe Borsani
Giuseppe Borsani
affiliation: Università di Brescia
research area(s): Genetics And Genomics, Computational Biology
Course: Molecular Genetics, Biotechnologies and Experimental Medicine
University/Istitution: Università di Brescia
1986 - 1990 - Milano - Istituto Sieroterapico Milanese - Research Scientist. Supervisor Prof. F.E. Baralle.
Research projects: Cloning and molecular analysis of erythrocyte membrane proteins from Hypertensive and Normotensive Milan rat strains. Characterization of ß-NGF mRNAs in human fetal tissues and analysis of human ß-NGF gene.
1987 - Oxford, U.K - Sir William Dunn School of Pathology, Oxford - Visiting Scientist. Supervisor Prof. F.E. Baralle.
Research project: identification of brain specific transcripts by subtractive hybridization.
1990 - 1993 – Houston, TX - Institute for Molecular Genetics, Baylor College of Medicine - Visiting Research Associate. Supervisor Prof. Andrea Ballabio
Research projects: Isolation and characterization of the murine Xist gene. Characterization of the Kallmann syndrome gene and molecular analysis of the Xp22 region in man.
1994 - Houston, TX - Institute for Molecular Genetics, Baylor College of Medicine - Research Assistant Professor. Director Prof. C. Thomas Caskey
Research projects: Identification and analysis of a gene family of chloride channels in man and mouse.
1995 - 2000 - Milano - Telethon Institute of Genetics and Medicine - Research Unit Coordinator. Director Prof. Andrea Ballabio
Research projects: Identification of genes differentially expressed from undifferentiated and differentiated NT2-D1 teratocarcinoma cells. Cloning and functional analysis of Rox, a new member of the Myc, Max, Mxi protein family. Large-scale generation of full length cDNA sequences (EUROIMAGE Consortium). Identifications of novel human genes (DRES - Drosophila Related, Expressed Sequences) similar to Drosophila mutant genes. Identification of genes involved in eye-related human inherited disorders. Identification of genes involved in sex-reversal phenotype in the mouse. Identification of the genes responsible for a X-linked late-onset sensorineural deafness, lysinuric protein intolerance, non type I cystinuria and mucolipidosis type IV. Development of bioinformatics resources for gene identification projects.
2000 - 2001 – Napoli – Telethon Institute of Genetics and Medicine – Visiting Scientist. Director Prof. Andrea Ballabio.
2000 - 2006 - Brescia - University of Brescia – Faculty of Medicine - Associate Professor in Applied Biology
2006 - present - Brescia - University of Brescia – Faculty of Medicine - Full Professor in Genetics
Research projects: study of the genetic and molecular basis of some inherited metabolic diseases (lysinuric protein intolerance, non type I cystinuria and mucolipidosis type IV). Identification and characterization of sialidases in mammals and other vertebrates. Caracterization of chromosomal rearrangements in patients with severe congenital diseases. Zebrafish as a model for the study of genetic disease.
Giuseppe Borsani is a molecular geneticist who has always been focused on the identification and characterization of genes of biomedical relevance, in particular those involved in mendelian genetic disorders. In his research projects he uses a combination of experimental and bioinformatic approaches, with particular attention to the use of comparative genomics and animal models for unraveling the pathogenic mechanisms of diseases.
- C. Vantaggiato, S. Bondioni, G. Airoldi, A. Bozzato, G. Borsani, E. I. Rugarli, N. Bresolin, E. Clementi and M. T. Bassi (2011) Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. Brain, 134: 1808-28.
- N. Chiarelli, M. Ritelli, N. Zoppi, A. Benini, G. Borsani, S. Barlati and M. Colombi (2011) Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene (slc2a10) in Danio rerio. Int J Dev Biol. (in press)
- E. Monti, E. Bonten, A. D'Azzo, R. Bresciani, B. Venerando, G. Borsani, R. Schauer and G. Tettamanti (2010) Sialidases in vertebrates: a family of enzymes tailored for several cell functions. Adv Carbohydr Chem Biochem, 64: 403-79.
- D. Zizioli, E. Forlanelli, M. Guarienti, S. Nicoli, A. Fanzani, R. Bresciani, G. Borsani, A. Preti, F. Cotelli and P. Schu (2010) Characterization of the AP-1 mu1A and mu1B adaptins in zebrafish (Danio rerio). Dev Dyn, 239: 2404-12.
- G. Borsani, G. Piovani, N. Zoppi, V. Bertini, R. Bini, L. Notarangelo and S. Barlati (2008) Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype. Eur J Med Genet, 51: 292-302.
- A. Bozzato, S. Barlati and G. Borsani (2008) Gene expression profiling of mucolipidosis type IV fibroblasts reveals deregulation of genes with relevant functions in lysosome physiology. Biochim Biophys Acta, 1782: 250-8.
- M. Manzoni, P. Colombi, N. Papini, L. Rubaga, N. Tiso, A. Preti, B. Venerando, G. Tettamanti, R. Bresciani, F. Argenton, G. Borsani and E. Monti (2007) Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). Biochem J, 408: 395-406.
- G. Zanchetti, P. Colombi, M. Manzoni, L. Anastasia, L. Caimi, G. Borsani, B. Venerando, G. Tettamanti, A. Preti, E. Monti and R. Bresciani (2007) Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structures. Biochem J, 408: 211-9.
- M. P. Sperandeo, P. Annunziata, A. Bozzato, P. Piccolo, L. Maiuri, M. D'Armiento, A. Ballabio, G. Corso, G. Andria, G. Borsani and G. Sebastio (2007) Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance. Am J Physiol Cell Physiol, 293: C191-8.
- G. Piovani, G. Borsani, V. Bertini, V. M. Kalscheuer, P. Viertel, D. Bellotti, D. Valseriati and S. Barlati (2006) Unexpected identification of two interstitial deletions in a patient with a pericentric inversion of a chromosome 4 and an abnormal phenotype. Eur J Med Genet, 49: 215-23.
A. Valerio, F. Boroni, M. Benarese, I. Sarnico, V. Ghisi, L. G. Bresciani, M. Ferrario, G. Borsani, P. Spano and M. Pizzi (2006) NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production. Eur J Neurosci, 23: 1711-20.
M. T. Bassi, M. Manzoni, R. Bresciani, M. T. Pizzo, A. Della Monica, S. Barlati, E. Monti and G. Borsani (2005) Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene, 345: 173-82.
M. Pineda, M. Font, M. T. Bassi, M. Manzoni, G. Borsani, V. Marigo, E. Fernandez, R. M. Rio, J. Purroy, A. Zorzano, V. Nunes and M. Palacin (2004) The amino acid transporter asc-1 is not involved in cystinuria. Kidney Int, 66: 1453-64.
M. Manzoni, E. Monti, R. Bresciani, A. Bozzato, S. Barlati, M. T. Bassi and G. Borsani (2004) Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization. FEBS Lett, 567: 219-24.
E. Monti, M. T. Bassi, R. Bresciani, S. Civini, G. L. Croci, N. Papini, M. Riboni, G. Zanchetti, A. Ballabio, A. Preti, G. Tettamanti, B. Venerando and G. Borsani (2004) Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Genomics, 83: 445-53.
- C. Tringali, N. Papini, P. Fusi, G. Croci, G. Borsani, A. Preti, P. Tortora, G. Tettamanti, B. Venerando and E. Monti (2004) Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules. J Biol Chem, 279: 3169-79.
No projects are available to students for the current accademic year.