Maria Ruzzene
e-mail: maria.ruzzene AT unipd.it
affiliation: Università di Padova
research area(s): Chemical Biology, Cell Biology
Course:
Biosciences and Biotechnologies
University/Istitution: Università di Padova
University/Istitution: Università di Padova
Born in Vicenza, 17 December 1961
Present position: researcher, Dept. Biomedical Sciences, University of Padova
EDUCATION
Degree cum laude in Biological Sciences, University of Padova, Italy (1985).
Ph.D. in Molecular and Cellular Biology and Pathology, University of Padova, Dept. of Biological Chemistry, Padova, Italy (1991).
ABROAD FELLOWSHIPS
EMBO fellowship, Friedrich Mieschner Institute, Basel, Switzerland (1989).
CNR-NATO fellowship, Harvard Medical School, Boston, USA (1995).
Visiting scientist, Harvard Medical School, Boston, USA (1998), with fellowship from the Giovanni Armenise- Harvard Foundation.
GRANTS
She has been responsible of several scientific projects funded by institutional grants, since 2002.
In 2005 she received a grant from the University of Padova for the project “Role of CK2-dependent phosphorylation of mitochondrial proteins in the ischemic injury of the heart”. In 2007 she received a grant from the Italian Ministry of University and Research (PRIN-2007) for the project "Role of protein kinase CK2 in regulating sorcin functions and interactions in supramolecular complexes". In 2010 her project “Protein kinase Akt/PKB and regulation of cell motility” was granted for a two-year fellowship. In 2011 she received a grant from the University of Padova for the project “The ceRNA (competitive endogenous RNA) hypothesis for the regulation of protein kinase CK2 in tumors”. Other members of her laboratory have obtained several grants (such as European Projects, PRIN from the Italian Ministry of University and Research, AIRC, Italian Association for Cancer Research) with programs where her personal research projects have been included.
REVIEWER ACTIVITY
She performs activity as reviewer for international journals (such as Journal of Biological Chemistry, Cell Death and Differentiation, Biochimica Biophysica Acta, ChemBiochem, and others).
TEACHING ACTIVITY
She is teacher of Chemistry and Biochemistry at the Medical School, University of Padova, Italy.
She is a member of the teaching staff of the PhD School in Biosciences and Biotechnologies, University of Padova
SCIENTIFIC INTERESTS
She has been always involved in projects concerning protein phosphorylation and structural and functional characterization of protein kinases and phosphatases.
She is presently interested in protein kinases involved in signal transduction and in the regulation of cell death/survival.
She is author of 72 scientific papers published in international journals (H-index 28), 4 chapters on scientific books, and several communications and posters at international meetings.
Present position: researcher, Dept. Biomedical Sciences, University of Padova
EDUCATION
Degree cum laude in Biological Sciences, University of Padova, Italy (1985).
Ph.D. in Molecular and Cellular Biology and Pathology, University of Padova, Dept. of Biological Chemistry, Padova, Italy (1991).
ABROAD FELLOWSHIPS
EMBO fellowship, Friedrich Mieschner Institute, Basel, Switzerland (1989).
CNR-NATO fellowship, Harvard Medical School, Boston, USA (1995).
Visiting scientist, Harvard Medical School, Boston, USA (1998), with fellowship from the Giovanni Armenise- Harvard Foundation.
GRANTS
She has been responsible of several scientific projects funded by institutional grants, since 2002.
In 2005 she received a grant from the University of Padova for the project “Role of CK2-dependent phosphorylation of mitochondrial proteins in the ischemic injury of the heart”. In 2007 she received a grant from the Italian Ministry of University and Research (PRIN-2007) for the project "Role of protein kinase CK2 in regulating sorcin functions and interactions in supramolecular complexes". In 2010 her project “Protein kinase Akt/PKB and regulation of cell motility” was granted for a two-year fellowship. In 2011 she received a grant from the University of Padova for the project “The ceRNA (competitive endogenous RNA) hypothesis for the regulation of protein kinase CK2 in tumors”. Other members of her laboratory have obtained several grants (such as European Projects, PRIN from the Italian Ministry of University and Research, AIRC, Italian Association for Cancer Research) with programs where her personal research projects have been included.
REVIEWER ACTIVITY
She performs activity as reviewer for international journals (such as Journal of Biological Chemistry, Cell Death and Differentiation, Biochimica Biophysica Acta, ChemBiochem, and others).
TEACHING ACTIVITY
She is teacher of Chemistry and Biochemistry at the Medical School, University of Padova, Italy.
She is a member of the teaching staff of the PhD School in Biosciences and Biotechnologies, University of Padova
SCIENTIFIC INTERESTS
She has been always involved in projects concerning protein phosphorylation and structural and functional characterization of protein kinases and phosphatases.
She is presently interested in protein kinases involved in signal transduction and in the regulation of cell death/survival.
She is author of 72 scientific papers published in international journals (H-index 28), 4 chapters on scientific books, and several communications and posters at international meetings.
She has been always involved in projects concerning protein phosphorylation and structural and functional characterization of protein kinases and phosphatases.
She is presently interested in protein kinases involved in signal transduction and in the regulation of cell death/survival.
She is presently interested in protein kinases involved in signal transduction and in the regulation of cell death/survival.
SELECYED RECENT PUBLICATIONS
1. Manni S, Brancalion A, Quotti Tubi L, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, RUZZENE M., Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F. (in stampa). Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response . CLINICAL CANCER RESEARCH, ISSN: 1078-0432
2. Stefania Sarno, Marco Mazzorana, Ryan Traynor, RUZZENE M., Giorgio Cozza, Mario A. Pagano, Flavio Meggio, Giuseppe Zagotto, Roberto Battistutta, Lorenzo A. Pinna (2012). Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 69; p. 449-460, ISSN: 1420-682X, doi: 10.1007/s00018-011-0758-7
3. F. PIAZZA, Manni S, RUZZENE M., Pinna LA, Gurrieri C, Semenzato G. (2012). Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways. LEUKEMIA, ISSN: 0887-6924
4. STAHL S, BRANCA RM, EFAZAT G, RUZZENE M., ZHIVOTOVSKY B, LEWENSOHN R, VIKTORSSON K, LEHTIO J (2011). Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor. JOURNAL OF PROTEOME RESEARCH, vol. 10; p. 2566-2578, ISSN: 1535-3893, doi: 10.1021/pr200037u
5. RUZZENE M., PINNA L.A. (2010). Addiction to protein kinase CK2: A common denominator of diverse cancer cells?. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1804; p. 499-504, ISSN: 1570-9639, doi: 10.1016/j.bbapap.2009.07.018
6. DI MAIRA G, BRUSTOLON F, PINNA L.A., RUZZENE M. (2009). Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 66; p. 3363-3373, ISSN: 1420-682X, doi: 10.1007/s00018-009-0108-1
7. DI MAIRA G, BRUSTOLON F, TOSONI K, BELLI S, KRAMER SD, PINNA L.A., RUZZENE M. (2008). Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis. MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 316; p. 155-161, ISSN: 0300-8177, doi: 10.1007/s11010-008-9813-6
8. FACCHIN S, RUZZENE M., PEGGION C, SARTORI G, CARIGNANI G, MARIN O, BRUSTOLON F., LOPREIATO R, PINNA L.A (2007). Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB
. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 64; p. 2680-2689, ISSN: 1420-682X, doi: 10.1007/s00018-007-7179-7
9. DI MAIRA G, BRUSTOLON F, BERTACCHINI J, TOSONI K, MARMIROLI S, PINNA L.A., RUZZENE M. (2007). Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.
. ONCOGENE, vol. 26; p. 6915-6926, ISSN: 0950-9232, doi: 10.1038/sj.onc.1210495
10. PIAZZA FA, RUZZENE M., GURRIERI C, MONTINI B, BONANNI L, CHIOETTO G, DI MAIRA G, BARBON F, CABRELLE A, ZAMBELLO R, ADAMI F, TRENTIN L, PINNA LA, SEMENZATO G (2006). Multiple myeloma cell survival relies on high activity of protein kinase CK2. BLOOD, vol. 108; p. 1698-1707, ISSN: 0006-4971, doi: 10.1182/blood-2005-11-013672
1. Manni S, Brancalion A, Quotti Tubi L, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, RUZZENE M., Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F. (in stampa). Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response . CLINICAL CANCER RESEARCH, ISSN: 1078-0432
2. Stefania Sarno, Marco Mazzorana, Ryan Traynor, RUZZENE M., Giorgio Cozza, Mario A. Pagano, Flavio Meggio, Giuseppe Zagotto, Roberto Battistutta, Lorenzo A. Pinna (2012). Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 69; p. 449-460, ISSN: 1420-682X, doi: 10.1007/s00018-011-0758-7
3. F. PIAZZA, Manni S, RUZZENE M., Pinna LA, Gurrieri C, Semenzato G. (2012). Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways. LEUKEMIA, ISSN: 0887-6924
4. STAHL S, BRANCA RM, EFAZAT G, RUZZENE M., ZHIVOTOVSKY B, LEWENSOHN R, VIKTORSSON K, LEHTIO J (2011). Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor. JOURNAL OF PROTEOME RESEARCH, vol. 10; p. 2566-2578, ISSN: 1535-3893, doi: 10.1021/pr200037u
5. RUZZENE M., PINNA L.A. (2010). Addiction to protein kinase CK2: A common denominator of diverse cancer cells?. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, vol. 1804; p. 499-504, ISSN: 1570-9639, doi: 10.1016/j.bbapap.2009.07.018
6. DI MAIRA G, BRUSTOLON F, PINNA L.A., RUZZENE M. (2009). Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 66; p. 3363-3373, ISSN: 1420-682X, doi: 10.1007/s00018-009-0108-1
7. DI MAIRA G, BRUSTOLON F, TOSONI K, BELLI S, KRAMER SD, PINNA L.A., RUZZENE M. (2008). Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis. MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 316; p. 155-161, ISSN: 0300-8177, doi: 10.1007/s11010-008-9813-6
8. FACCHIN S, RUZZENE M., PEGGION C, SARTORI G, CARIGNANI G, MARIN O, BRUSTOLON F., LOPREIATO R, PINNA L.A (2007). Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB
. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 64; p. 2680-2689, ISSN: 1420-682X, doi: 10.1007/s00018-007-7179-7
9. DI MAIRA G, BRUSTOLON F, BERTACCHINI J, TOSONI K, MARMIROLI S, PINNA L.A., RUZZENE M. (2007). Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.
. ONCOGENE, vol. 26; p. 6915-6926, ISSN: 0950-9232, doi: 10.1038/sj.onc.1210495
10. PIAZZA FA, RUZZENE M., GURRIERI C, MONTINI B, BONANNI L, CHIOETTO G, DI MAIRA G, BARBON F, CABRELLE A, ZAMBELLO R, ADAMI F, TRENTIN L, PINNA LA, SEMENZATO G (2006). Multiple myeloma cell survival relies on high activity of protein kinase CK2. BLOOD, vol. 108; p. 1698-1707, ISSN: 0006-4971, doi: 10.1182/blood-2005-11-013672
No projects are available to students for the current accademic year.