Fabio Mammano
e-mail: fabio.mammano AT unipd.it
website: www.vimm.it/research/group.php?PI=8
affiliation: Università di Padova
research area(s): Neuroscience, Computational Biology
Course:
Biosciences and Biotechnologies
University/Istitution: Università di Padova
University/Istitution: Università di Padova
FABIO MAMMANO
Born in Asiago (VI) on Aug 28, 1963.
2002-present: Associate Professor of Applied Physics, Department of Physics & Astronomy “G. Galilei”, University of Padua, Italy.
1995-2002: Assistant Professor, Biophysics Sector, International School for Advanced Studies (SISSA), Trieste, Italy.
1992-1995: Research Associate (Grade 1A, with Academic Status), Dept. of Physiology, University of Bristol (UK).
1990–1991: Assistant Professor of Physics, Military Academy of the Italian Navy, Leghorn, Italy.
DIPLOMAS
1992: Doctor Philosophiae (Ph.D.) in Biophysics, SISSA;
(supervisor, J.F. Ashmore, F.R.S., University College London, UK).
1989: Magister Philosophiae (M.Phil.) in Biophysics, SISSA;
(supervisors: A. Borsellino, SISSA, and C.L. Searle, MIT, Boston, USA).
1987: BSc in Physics, cum laude, University of Parma, Italy.
RESEARCH FELLOWSHIPS
-ICGEB Postdoctoral Fellowship, May 1995 – Nov 1995.
-Wellcome Trust Postdoctoral Fellowship, April 1992 – April 1995.
-Wolfson Foundation Research Fellowship, Sept 1991 – Mar 1992.
-Accademia dei Lincei / Royal Society “Science exchange fellowship”, Mar 1991 – Sept 1991.
-SISSA Ph.D. Fellowship, Dec 1990 – Jan 1992.
-SISSA Ph.D. Fellowship, Nov 1987 – Sept 1989.
VISITING SCIENTIST
-Dept. of Physiology, University of Bristol (UK); Mar 1991 – Mar 1992.
-Research Laboratory of Electronics, MIT, Boston, USA; Dec 1988 – Sept 1989.
RESEARCH CONSULTANT
-National Institute on Deafness and Other Communication Disorders (NIDCD), Bethesda (USA); June 10, 1996 – July 30, 1996.
TECHNICAL AND SCIENTIFIC ROLES
- Venetian Institute of Molecular Medicine (VIMM), Padova: Principal Investigator (PI) and Member of the Scientific Committee (2001-present)
- University of Padova, Dept. of Physics: Member of the Council (2003-2006)
- Società Italiana di Biofisica Pura e Applicata (SIBPA):
Member of the Scientific Committee (2001-2004)
ORGANIZATION OF INTERNATIONAL CONFERENCES
- Eurohear Theoretical Training Programme "Imaging": Member of the Scientific Committee and Instructor; Venice, 16-22 June 2007.
- Eurohear Theoretical Training Programme "Hair Cell Physiology":
Member of the Scientific Committee and Instructor; Venice, 3-9 June 2006.
- SIPBA School "Sensory Transduction":
Member of the Scientific Committee and Instructor; Venice, 27 - 31 January 2003.
MAJOR CONTRIBUTIONS TO EARLY CAREERS OF EXCELLENT RESEARCHERS
A) Thesis Director of 9 Ph.D. students, among which: Dr. Laura Lagostena, winner of the Ciani Prize for
best Ph.D. thesis in Biophysics (thesis title: "Calcium dynamics in sensory and supporting cells of the
organ of Corti"); Martina Beltramello, currently a Scientist in the group of prof. Antonio Lanzavecchia at
the Institute for Research in Biomedicine, Bellinzona (CH); Dr. Valeria Piazza, subsequently trained as a post-doc in Harvard Medical School with Prof. D. P. Corey; Dr. Victor Hernandez, subsequently trained as a post-doc with Prof. Tobias Moser (University of Göttingen) and currently working as an independent researcher at University of Guanajuato, Mexico.
B) Supervisor of 12 post-doctoral fellows, among which: Dr. Mario Bortolozzi, now University researcher at Padova University and Visiting Scientist in the laboratory of Prof. Richard Vaughan-Jones at Oxford (UK); Dr. Saida Ortolano, now on a tenure track as Contracted Research Fellow at the Department of Pathology and Neuropathology, University Hospital of Vigo, Spain; Dr. Fabio Anselmi, currently a post-doc with Prof. Tomaso Poggio at MIT, Boston; Dr. Paromita Majumder, currently a post-doc with Dr. Jonathan Gale at University College London; Dr. Andrea Lelli, currently a post-doc with Prof. Christine Petit at Institute Pasteur, Paris.
Born in Asiago (VI) on Aug 28, 1963.
2002-present: Associate Professor of Applied Physics, Department of Physics & Astronomy “G. Galilei”, University of Padua, Italy.
1995-2002: Assistant Professor, Biophysics Sector, International School for Advanced Studies (SISSA), Trieste, Italy.
1992-1995: Research Associate (Grade 1A, with Academic Status), Dept. of Physiology, University of Bristol (UK).
1990–1991: Assistant Professor of Physics, Military Academy of the Italian Navy, Leghorn, Italy.
DIPLOMAS
1992: Doctor Philosophiae (Ph.D.) in Biophysics, SISSA;
(supervisor, J.F. Ashmore, F.R.S., University College London, UK).
1989: Magister Philosophiae (M.Phil.) in Biophysics, SISSA;
(supervisors: A. Borsellino, SISSA, and C.L. Searle, MIT, Boston, USA).
1987: BSc in Physics, cum laude, University of Parma, Italy.
RESEARCH FELLOWSHIPS
-ICGEB Postdoctoral Fellowship, May 1995 – Nov 1995.
-Wellcome Trust Postdoctoral Fellowship, April 1992 – April 1995.
-Wolfson Foundation Research Fellowship, Sept 1991 – Mar 1992.
-Accademia dei Lincei / Royal Society “Science exchange fellowship”, Mar 1991 – Sept 1991.
-SISSA Ph.D. Fellowship, Dec 1990 – Jan 1992.
-SISSA Ph.D. Fellowship, Nov 1987 – Sept 1989.
VISITING SCIENTIST
-Dept. of Physiology, University of Bristol (UK); Mar 1991 – Mar 1992.
-Research Laboratory of Electronics, MIT, Boston, USA; Dec 1988 – Sept 1989.
RESEARCH CONSULTANT
-National Institute on Deafness and Other Communication Disorders (NIDCD), Bethesda (USA); June 10, 1996 – July 30, 1996.
TECHNICAL AND SCIENTIFIC ROLES
- Venetian Institute of Molecular Medicine (VIMM), Padova: Principal Investigator (PI) and Member of the Scientific Committee (2001-present)
- University of Padova, Dept. of Physics: Member of the Council (2003-2006)
- Società Italiana di Biofisica Pura e Applicata (SIBPA):
Member of the Scientific Committee (2001-2004)
ORGANIZATION OF INTERNATIONAL CONFERENCES
- Eurohear Theoretical Training Programme "Imaging": Member of the Scientific Committee and Instructor; Venice, 16-22 June 2007.
- Eurohear Theoretical Training Programme "Hair Cell Physiology":
Member of the Scientific Committee and Instructor; Venice, 3-9 June 2006.
- SIPBA School "Sensory Transduction":
Member of the Scientific Committee and Instructor; Venice, 27 - 31 January 2003.
MAJOR CONTRIBUTIONS TO EARLY CAREERS OF EXCELLENT RESEARCHERS
A) Thesis Director of 9 Ph.D. students, among which: Dr. Laura Lagostena, winner of the Ciani Prize for
best Ph.D. thesis in Biophysics (thesis title: "Calcium dynamics in sensory and supporting cells of the
organ of Corti"); Martina Beltramello, currently a Scientist in the group of prof. Antonio Lanzavecchia at
the Institute for Research in Biomedicine, Bellinzona (CH); Dr. Valeria Piazza, subsequently trained as a post-doc in Harvard Medical School with Prof. D. P. Corey; Dr. Victor Hernandez, subsequently trained as a post-doc with Prof. Tobias Moser (University of Göttingen) and currently working as an independent researcher at University of Guanajuato, Mexico.
B) Supervisor of 12 post-doctoral fellows, among which: Dr. Mario Bortolozzi, now University researcher at Padova University and Visiting Scientist in the laboratory of Prof. Richard Vaughan-Jones at Oxford (UK); Dr. Saida Ortolano, now on a tenure track as Contracted Research Fellow at the Department of Pathology and Neuropathology, University Hospital of Vigo, Spain; Dr. Fabio Anselmi, currently a post-doc with Prof. Tomaso Poggio at MIT, Boston; Dr. Paromita Majumder, currently a post-doc with Dr. Jonathan Gale at University College London; Dr. Andrea Lelli, currently a post-doc with Prof. Christine Petit at Institute Pasteur, Paris.
2001 – present: Principal Investigator (PI), Venetian Institute of Molecular Medicine (VIMM), Foundation for Advanced Biomedical Research, Padua – Italy (since 2001). The majority of my research focuses on sensory and signal transduction in the inner ear, which I investigate using various experimental techniques and modeling approaches.
Current composition of research team: Mario Bortolozzi: Assistant Professor of Applied Physics, PhD in Neurobiology, MSc in Physics. Francesco Zonta: Research Associate, PhD in Computational Physics, MSc in Physics. Catalin Ciubotaru: CNR Technologist, PhD in Neurobiology, MSc in Physics. Giulia Crispino: post-doc, PhD in Neurobiology, MSc in Biology. Fabian G Ramirez; post-doc, Medical Doctor. Federico Ceriani: PhD student, MSc in Physics. Elena Simeonato: PhD student, MSc in Biomedical Technologies. Veronica Zorzi: Technician.
Current composition of research team: Mario Bortolozzi: Assistant Professor of Applied Physics, PhD in Neurobiology, MSc in Physics. Francesco Zonta: Research Associate, PhD in Computational Physics, MSc in Physics. Catalin Ciubotaru: CNR Technologist, PhD in Neurobiology, MSc in Physics. Giulia Crispino: post-doc, PhD in Neurobiology, MSc in Biology. Fabian G Ramirez; post-doc, Medical Doctor. Federico Ceriani: PhD student, MSc in Physics. Elena Simeonato: PhD student, MSc in Biomedical Technologies. Veronica Zorzi: Technician.
1. MAMMANO F (2012)
ATP-dependent intercellular Ca2+ signaling in the developing cochlea: facts, fantasies and perspectives.
SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY
(invited review)
doi: 10.1016/j.semcdb.2012.09.004
2. RODRIGUEZ L, SIMEONATO E, SCIMEMI P, ANSELMI F, CALÌ B, CRISPINO G, CIUBOTARU CD, BORTOLOZZI M, RAMIREZ FG, MAJUMDER P, ARSLAN E, DE CAMILLI P, POZZAN T, MAMMANO F (2012)
Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high frequency hearing acquisition
PROC NATL ACAD SCI USA 109 (35): 14013-14018.
doi: 10.1073/pnas.1211869109
3. BLAAUW B, DEL PICCOLO P, RODRIGUEZ L, HERNANDEZ GONZALEZ VH, AGATEA L, SOLAGNA F, MAMMANO F, POZZAN T, SCHIAFFINO S. (2012)
No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in isolated fibers of adult mouse skeletal muscle.
JOURNAL OF GENERAL PHYSIOLOGY 140(2):235-41 (Epub 16 Jul 2012).
(cover article)
doi: 10.1085/jgp.201110747
4. CERIANI F, MAMMANO F (2012)
Calcium signaling in the cochlea – Molecular mechanisms and physiopathological implications
CELL COMMUNICATION AND SIGNALING 20:10
doi: 10.1186/1478-811X-10-20
(invited review)
5. ZONTA F, POLLES G, ZANOTTI G, MAMMANO F (2012)
Permeation pathway of homomeric connexin 26 and connexin 30 channels investigated by molecular dynamics.
J BIOMOL STRUCT DYN 29(5): 985-998.
6. DECROCK E, KRYSKO DV, VINKEN M, KACZMAREK A, CRISPINO G, BOL M, WANG N, DE BOCK M, DE VUYST E, NAUS CC, ROGIERS V, VANDENABEELE P, ERNEUX C, MAMMANO F, BULTYNCK G, LEYBAERT L (2012)
Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis.
CELL DEATH DIFFER 19(6):947-957.
doi: 10.1038/cdd.2011.176
7. CRISPINO G, DI PASQUALE G, SCIMEMI P, RODRIGUEZ L, GALINDO RAMIREZ F, DE SIATI RD, SANTARELLI RM, ARSLAN E, BORTOLOZZI M, CHIORINI JA, MAMMANO F (2011)
BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf CX26Sox10cre mice
PLOS ONE Volume: 6 Issue: 8 Article Number: e23279
doi: 10.1371/journal.pone.0023279
8. MAMMANO F (2011)
Ca2+ homeostasis defects and hereditary hearing loss
BIOFACTORS Volume: 37 Issue: 3 Special Issue: SI Pages: 182-188
doi: 10.1002/biof.150
(invited review)
9. BORTOLETTO F, BONOLI C, PANIZZOLO P, CIUBOTARU CD, MAMMANO F (2011)
Multiphoton fluorescence microscopy with GRIN objective aberration correction by low order adaptive optics
PLOS One Volume: 6, Issue: 7, Article Number: e22321.
doi: 10.1371/journal.pone.0022321
10. MAJUMDER P, CRISPINO G, RODRIGUEZ L, CIUBOTARU CD, ANSELMI F, PIAZZA V, BORTOLOZZI M, MAMMANO F (2010)
ATP–mediated cell–cell signalling in the organ of Corti: the role of connexin channels
PURINERGIC SIGNALING 6(2): 167-187.
doi: 10.1007/s11302-010-9192-9
(invited research article)
11. SCHÜTZ M, SCIMEMI P, MAJUMDER P, DE SIATI RD, CRISPINO G, RODRIGUEZ L, BORTOLOZZI M, SANTARELLI R, SEYDEL A, SONNTAG S, INGHAM N, STEEL KP, WILLECKE K, MAMMANO F (2010)
The human deafness–associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non–sensory cells in knock in mice
HUMAN MOLECULAR GENETICS 19(24): 4759-4773.
doi: 10.1093/hmg/ddq402
(cover article)
12. BORTOLOZZI M, BRINI M, PARKINSON N, CRISPINO G, SCIMEMI P, DE SIATI RD, DI LEVA F, PARKER A, ORTOLANO S, ARSLAN E, BROWN S, CARAFOLI E, MAMMANO F (2010)
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice
JOURNAL OF BIOLOGICAL CHEMISTRY 285(48) 37693-37703.
doi: 10.1074/jbc.M110.170092
13. PANTANO S, ZONTA F, MAMMANO F (2008)
A fully atomistic model of the Cx32 connexon
PLOS ONE 3(7): e2614. doi:10.1371/journal.pone.0002614
14. ANSELMI F, HERNANDEZ VH, CRISPINO G, SEYDEL A, ORTOLANO S, ROPER SD, KESSARIS N, RICHARDSON W, RICKHEIT G, FILIPPOV MA, MONYER H, MAMMANO F (2008)
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear
PROC NATL ACAD SCI USA 105(48): 18770-18775.
15. BORTOLOZZI M, LELLI A, MAMMANO F (2008)
Calcium microdomains at presynaptic active zones of vertebrate hair cells unmasked by stochastic deconvolution
CELL CALCIUM 44(2):158-68.
16. ORTOLANO S, DI PASQUALE G, CRISPINO G, ANSELMI F, MAMMANO F*, CHIORINI J (2008)
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear
PROC NATL ACAD SCI USA 105(48): 18776-18781.
17. SPIDEN SL, BORTOLOZZI M, DI LEVA F, HRABÉ DE ANGELIS M, FUCHS H , LIM D, ORTOLANOS, INGHAMNJ, BRINI M, CARAFOLI E, MAMMANO F*, STEEL KP (2008)
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss
PLOS GENETICS 4(10):e1000238. Epub 2008 Oct 31.
ATP-dependent intercellular Ca2+ signaling in the developing cochlea: facts, fantasies and perspectives.
SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY
(invited review)
doi: 10.1016/j.semcdb.2012.09.004
2. RODRIGUEZ L, SIMEONATO E, SCIMEMI P, ANSELMI F, CALÌ B, CRISPINO G, CIUBOTARU CD, BORTOLOZZI M, RAMIREZ FG, MAJUMDER P, ARSLAN E, DE CAMILLI P, POZZAN T, MAMMANO F (2012)
Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high frequency hearing acquisition
PROC NATL ACAD SCI USA 109 (35): 14013-14018.
doi: 10.1073/pnas.1211869109
3. BLAAUW B, DEL PICCOLO P, RODRIGUEZ L, HERNANDEZ GONZALEZ VH, AGATEA L, SOLAGNA F, MAMMANO F, POZZAN T, SCHIAFFINO S. (2012)
No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in isolated fibers of adult mouse skeletal muscle.
JOURNAL OF GENERAL PHYSIOLOGY 140(2):235-41 (Epub 16 Jul 2012).
(cover article)
doi: 10.1085/jgp.201110747
4. CERIANI F, MAMMANO F (2012)
Calcium signaling in the cochlea – Molecular mechanisms and physiopathological implications
CELL COMMUNICATION AND SIGNALING 20:10
doi: 10.1186/1478-811X-10-20
(invited review)
5. ZONTA F, POLLES G, ZANOTTI G, MAMMANO F (2012)
Permeation pathway of homomeric connexin 26 and connexin 30 channels investigated by molecular dynamics.
J BIOMOL STRUCT DYN 29(5): 985-998.
6. DECROCK E, KRYSKO DV, VINKEN M, KACZMAREK A, CRISPINO G, BOL M, WANG N, DE BOCK M, DE VUYST E, NAUS CC, ROGIERS V, VANDENABEELE P, ERNEUX C, MAMMANO F, BULTYNCK G, LEYBAERT L (2012)
Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis.
CELL DEATH DIFFER 19(6):947-957.
doi: 10.1038/cdd.2011.176
7. CRISPINO G, DI PASQUALE G, SCIMEMI P, RODRIGUEZ L, GALINDO RAMIREZ F, DE SIATI RD, SANTARELLI RM, ARSLAN E, BORTOLOZZI M, CHIORINI JA, MAMMANO F (2011)
BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf CX26Sox10cre mice
PLOS ONE Volume: 6 Issue: 8 Article Number: e23279
doi: 10.1371/journal.pone.0023279
8. MAMMANO F (2011)
Ca2+ homeostasis defects and hereditary hearing loss
BIOFACTORS Volume: 37 Issue: 3 Special Issue: SI Pages: 182-188
doi: 10.1002/biof.150
(invited review)
9. BORTOLETTO F, BONOLI C, PANIZZOLO P, CIUBOTARU CD, MAMMANO F (2011)
Multiphoton fluorescence microscopy with GRIN objective aberration correction by low order adaptive optics
PLOS One Volume: 6, Issue: 7, Article Number: e22321.
doi: 10.1371/journal.pone.0022321
10. MAJUMDER P, CRISPINO G, RODRIGUEZ L, CIUBOTARU CD, ANSELMI F, PIAZZA V, BORTOLOZZI M, MAMMANO F (2010)
ATP–mediated cell–cell signalling in the organ of Corti: the role of connexin channels
PURINERGIC SIGNALING 6(2): 167-187.
doi: 10.1007/s11302-010-9192-9
(invited research article)
11. SCHÜTZ M, SCIMEMI P, MAJUMDER P, DE SIATI RD, CRISPINO G, RODRIGUEZ L, BORTOLOZZI M, SANTARELLI R, SEYDEL A, SONNTAG S, INGHAM N, STEEL KP, WILLECKE K, MAMMANO F (2010)
The human deafness–associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non–sensory cells in knock in mice
HUMAN MOLECULAR GENETICS 19(24): 4759-4773.
doi: 10.1093/hmg/ddq402
(cover article)
12. BORTOLOZZI M, BRINI M, PARKINSON N, CRISPINO G, SCIMEMI P, DE SIATI RD, DI LEVA F, PARKER A, ORTOLANO S, ARSLAN E, BROWN S, CARAFOLI E, MAMMANO F (2010)
The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice
JOURNAL OF BIOLOGICAL CHEMISTRY 285(48) 37693-37703.
doi: 10.1074/jbc.M110.170092
13. PANTANO S, ZONTA F, MAMMANO F (2008)
A fully atomistic model of the Cx32 connexon
PLOS ONE 3(7): e2614. doi:10.1371/journal.pone.0002614
14. ANSELMI F, HERNANDEZ VH, CRISPINO G, SEYDEL A, ORTOLANO S, ROPER SD, KESSARIS N, RICHARDSON W, RICKHEIT G, FILIPPOV MA, MONYER H, MAMMANO F (2008)
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear
PROC NATL ACAD SCI USA 105(48): 18770-18775.
15. BORTOLOZZI M, LELLI A, MAMMANO F (2008)
Calcium microdomains at presynaptic active zones of vertebrate hair cells unmasked by stochastic deconvolution
CELL CALCIUM 44(2):158-68.
16. ORTOLANO S, DI PASQUALE G, CRISPINO G, ANSELMI F, MAMMANO F*, CHIORINI J (2008)
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear
PROC NATL ACAD SCI USA 105(48): 18776-18781.
17. SPIDEN SL, BORTOLOZZI M, DI LEVA F, HRABÉ DE ANGELIS M, FUCHS H , LIM D, ORTOLANOS, INGHAMNJ, BRINI M, CARAFOLI E, MAMMANO F*, STEEL KP (2008)
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss
PLOS GENETICS 4(10):e1000238. Epub 2008 Oct 31.
No projects are available to students for the current accademic year.