Licio Collavin
Licio Collavin
affiliation: LNCIB - Laboratorio Nazionale CIB, Trieste
research area(s): Cell Biology, Cancer Biology
Course: Molecular Biomedicine
University/Istitution: Università di Trieste
Graduated in Biological Sciences at the University of Trieste, Licio Collavin obtained his PhD from the International School for Advanced Studies (SISSA) in Trieste, working in the group of prof. Claudio Schneider at LNCIB. He did a three years postdoc in the lab of prof. Marc W. Kirschner, in the Department of Cell Biology at Harvard Medical School, Boston, MA (USA). Dr. Collavin is Associate Professor at the University of Trieste, Department of Life Sciences.
Research activity is broadly centered on molecular oncology, more specifically on the study of functional connections between signaling pathways controlling cell proliferation, differentiation, embryogenesis and cancer. Current projects are focused on the study of newly discovered, evolutionarily conserved interactors of p53 family proteins.
Di Minin, G., Bellazzo, A., Dal Ferro, M., Chiaruttini, G., Nuzzo, S., Bicciato, S., Piazza, S., Rami, D., Bulla, R., Sommaggio, R., Rosato, A., Del Sal, G., and Collavin, L. (2014). Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP. Molecular cell 56, 617-629.

Lunardi, A., Di Minin, G., Provero, P., Dal Ferro, M., Carotti, M., Del Sal, G., and Collavin, L. (2010). A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A 107: 6322-6327

Collavin, L., Lunardi, A., and Del Sal, G. (2010). p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death Differ 17: 901-911.

Lunardi, A., Chiacchiera, F., D'Este, E., Carotti, M., Dal Ferro, M., Di Minin, G., Del Sal, G., and Collavin, L. (2009). The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73. Biochem Biophys Res Commun 388: 428-433.

Mauri, F., McNamee, L.M., Lunardi, A., Chiacchiera, F., Del Sal, G., Brodsky, M.H., and Collavin, L. (2008). Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions. J Biol Chem 283: 20848-20856.

Collavin, L., Gostissa, M., Avolio, F., Secco, P., Ronchi, A., Santoro, C., and Del Sal, G. (2004). Modification of the erythroid transcription factor GATA-1 by SUMO-1. Proc Natl Acad Sci U S A 101: 8870-8875

Collavin, L., and Kirschner, M.W. (2003). The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development 130: 805-816.
Project Title:
Tumor suppressor pathways in development and cancer
Specific research projects will be discussed with interested applicants