Giorgio Inghirami
Giorgio Inghirami
e-mail:
affiliation: UniversitĂ  di Torino
research area(s): Cancer Biology, Molecular Biology
Courses:
  • Molecular Medicine
  • Biomedical Sciences and Human Oncology
University/Istitution: UniversitĂ  di Torino
ACADEMIC TRAINING & POSITIONS
1976-1978 Research experience, Department of General Pathology, University of Siena Medical School
1978-1980 Extern, Department of General Surgery, University of Siena Medical School
1980-1981 Extern, Department of General Surgery, University of Torino Medical School
1980-1981 Extern, Department of Nephrology and Dialysis, University of Torino Medical School
1981-1982 Intern, Department of Nephrology and Dialysis, University of Torino Medical School
1982-1983 Fogarty Fellow, Laboratory of Tumor Immunology and Biology (Dr. Jeffrey Schlom), " National Cancer Institute
1983-1985 Fogarty Fellow, Kidney Disease Section, (James E. Balow, M.D.), National Institutes of
Arthritis, Diabetes, Digestive and Kidney Diseases
1985-1986 Visiting Associate, Kidney Disease Section (James E. Balow, M.D.), National Institutes of Arthritis, Diabetes, Digestive and Kidney Diseases
1986-1987 Pathology Resident (PGY-1), New York University Medical Center, New York, NY
1987-1990 Pathology Resident (PGY-2-4), Columbia University, New York, NY
1990-1993 Assistant Professor, Columbia University, New York, NY
1991-1993 Assistant Attending, Presbyterian Hospital, New York, NY
1992-1993 Member of the Faculty of the Graduate School of Art and Sciences, " Columbia University, New York, NY"1993-2005 Associate Professor (tenured), New York University, New York, NY"1993-2005 Director of Molecular Pathology Laboratory, New York University, School of Medicine,
New York, NY
1998-2005 Director of Hematopathology, New York University, School of Medicine,
New York, NY
2000-2006 Associate Professor of Pathology, University of Turin, Italy
2002-2004 Consultant, Ortho-Clinical Diagnostic, Advance Diagnostic System, Johnson & Johnson
2005-2008 Consultant, Cell Signaling Technology, Danvers, MA, USA
2005-present Adjunct Associate Professor, New York University, School of Medicine, New York, NY
2005-present Director of Center of Experimental Research and Medical Science (CeRMS), University of Turin, Italy
2005-present Scientific President, International Foundation in Experimental Research Medicine, Turin, Italy
2005-present Consultant, Menarini Diagnostic, Menarini Industrie Farmaceutiche, Florence, Italy
2005-present Member of the Scientific Advisory Board, Oncology Program, Cephalon, West Chester, PA, USA
2006-present Professor of Pathology, University of Turin, Italy
2006-2007 Board Member, International School of Turin, Turin, Italy
2007-present Scientific Advisor, Biotechnology Foundation, Turin, Italy
2010-present Director of Anatomic Pathology, San Giovanni Battista Hospital, Turin, Italy
Molecular oncology, immunology, hematology.
1: Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, Pucciarini
A, Bigerna B, Pacini R, Wells VA, Sportoletti P, Pettirossi V, Mannucci R,
Elliott O, Liso A, Ambrosetti A, Pulsoni A, Forconi F, Trentin L, Semenzato G,
Inghirami G, Capponi M, Di Raimondo F, Patti C, Arcaini L, Musto P, Pileri S,
Haferlach C, Schnittger S, Pizzolo G, Fo" R, Farinelli L, Haferlach T,
Pasqualucci L, Rabadan R, Falini B. BRAF mutations in hairy-cell leukemia. N Engl
J Med. 2011 Jun 16;364(24):2305-15.
3: Riera L, Lasorsa E, Bonello L, Sismondi F, Tondat F, Di Bello C, Di Celle PF,
Chiarle R, Godio L, Pich A, Facchetti F, Ponzoni M, Marmont F, Zanon C, Bardelli
A, Inghirami G. Description of a novel Janus kinase 3 P132A mutation in acute
megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3
mutations in normal subjects. Leuk Lymphoma. 2011 May 23.
4: Martinelli P, Bonetti P, Sironi C, Pruneri G, Fumagalli C, Raviele PR, Volorio
S, Pileri S, Chiarle R, McDuff FK, Tusi BK, Turner SD, Inghirami G, Pelicci PG,
Colombo E. The lymphoma-associated NPM-ALK oncogene elicits a
p16INK4a/pRb-dependent tumor-suppressive pathway. Blood. 2011 Jun
16;117(24):6617-26. Epub 2011 Apr 25.
5: Barreca A, Lasorsa E, Riera L, Machiorlatti R, Piva R, Ponzoni M, Kwee I,
Bertoni F, Piccaluga PP, Pileri S, Inghirami G. Anaplastic lymphoma kinase (ALK)
in human cancer. J Mol Endocrinol. 2011 Apr 18.

6: Chigrinova E, Mian M, Shen Y, Greiner TC, Chan WC, Vose JM, Inghirami G,
Chiappella A, Baldini L, Ponzoni M, Ferreri AJ, Franceschetti S, Gaidano G, Tucci
A, Facchetti F, Lazure T, Lambotte O, Montes-Moreno S, Piris MA, Zucca E, Kwee I,
Bertoni F. Integrated profiling of diffuse large B-cell lymphoma with 7q gain. Br
J Haematol. 2011 May;153(4):499-503.


7: Piccaluga PP, Gazzola A, Mannu C, Agostinelli C, Bacci F, Sabattini E,
Sagramoso C, Piva R, Roncolato F, Inghirami G, Pileri SA. Pathobiology of
anaplastic large cell lymphoma. Adv Hematol. 2010:345053.
8: Scandurra M, Mian M, Greiner TC, Rancoita PM, De Campos CP, Chan WC, Vose JM,
Chigrinova E, Inghirami G, Chiappella A, Baldini L, Ponzoni M, Ferreri AJ,
Franceschetti S, Gaidano G, Montes-Moreno S, Piris MA, Facchetti F, Tucci A,
Nomdedeu JF, Lazure T, Lambotte O, Uccella S, Pinotti G, Pruneri G, Martinelli G,
Young KH, Tibiletti MG, Rinaldi A, Zucca E, Kwee I, Bertoni F. Genomic lesions
associated with a different clinical outcome in diffuse large B-Cell lymphoma
treated with R-CHOP-21. Br J Haematol. 2010 Nov;151(3):221-31.

9: Chigrinova E, Mian M, Scandurra M, Greiner TC, Chan WC, Vose JM, Inghirami G,
Chiappella A, Baldini L, Ponzoni M, Ferreri AJ, Franceschetti S, Gaidano G, Tucci
A, Facchetti F, Lazure T, Lambotte O, Montes-Moreno S, Piris MA, Nomdedeu JF,
Uccella S, Rancoita PM, Kwee I, Zucca E, Bertoni F. Diffuse large B-cell lymphoma
with concordant bone marrow involvement has peculiar genomic profile and poor
clinical outcome. Hematol Oncol. 2011 Mar;29(1):38-41.
10: Piva R, Agnelli L, Pellegrino E, Todoerti K, Grosso V, Tamagno I, Fornari A,
Martinoglio B, Medico E, Zam" A, Facchetti F, Ponzoni M, Geissinger E, Rosenwald
A, MÂșller-Hermelink HK, De Wolf-Peeters C, Piccaluga PP, Pileri S, Neri A,
Inghirami G. Gene expression profiling uncovers molecular classifiers for the
recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms.
J Clin Oncol. 2010 Mar 20;28(9):1583-90. Epub 2010 Feb 16.
11: Ambrogio C, Martinengo C, Voena C, Tondat F, Riera L, di Celle PF, Inghirami
G, Chiarle R. NPM-ALK oncogenic tyrosine kinase controls T-cell identity by
transcriptional regulation and epigenetic silencing in lymphoma cells. Cancer
Res. 2009 Nov 15;69(22):8611-9. Epub 2009 Nov 3.
12: Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch
E, Inghirami G, Chiarle R. The anaplastic lymphoma kinase controls cell shape and
growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res.
2008 Nov 1;68(21):8899-907. PubMed PMID: 18974134;
13: Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M,
Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ,
Chiarle R, Inghirami G. The enzymatic activity of 5-aminoimidazole-4-carboxamide
ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new
insights in ALK-mediated pathogenesis and the treatment of ALCL. Blood. 2009 Mar
19;113(12):2776-90. Epub 2008 Oct 9.
14: Bevilacqua G, Inghirami G. Collection, banking and diagnostic archiving of
tissues. Pathologica. 2008 Apr;100(2):49-54. Review. English, Italian.
15: Chiarle R, Martinengo C, Mastini C, Ambrogio C, D'Escamard V, Forni G,
Inghirami G. The anaplastic lymphoma kinase is an effective oncoantigen for
lymphoma vaccination. Nat Med. 2008 Jun;14(6):676-80.
16: Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. The anaplastic lymphoma
kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008 Jan;8(1):11-23.
Review.
No projects are available to students for the current accademic year.