Vittorio Enrico Avvedimento
Vittorio Enrico Avvedimento
affiliation: Università di Napoli Federico II
research area(s): Molecular Biology, Cancer Biology
Course: Molecular Pathology and Pathophysiology
University/Istitution: Università di Napoli Federico II
Research and Professional Experience:

1978-1979 Fogarty Fellowship at the Laboratory of Molecular Biology, Sect. Gene Regulation, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
1980- 1981 Visiting Associate at Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
1987-1988 American Cancer Society Fellow at the Institute of Cancer Res., Columbia University, New York, NY, USA
1990-1991 Visiting Scientist, Institute of Cancer Research, Columbia University, New York

Honors and Awards:

1977 National Academy of Medicine Award (US $ 1,000)
1988 Eleanor Roosevelt-American Cancer Society Fellow
1997-2000 Board of Directors R. Ceppellini Advanced School of Immunology
2001-2002 "L.Schaffner" Visiting Professor award, Columbia University Medical School, College of Physicians and Surgeons, New York, New York, USA.
2005 - 2008 Start Cup "Federico II" award Biotech (see web Winners 2005 and 2008 Start Cup Federico II).
2009 Scholar in Residence Italian Academy Advanced Studies, Columbia University, New York, USA
1. cAMP and Ras signalling.
2. The function(s) of Ras genes in metabolism and human diseases
3. Link between DNA methylation and repair
4. Transcription and metabolism
Svegliati Baroni SS, Santillo M, Bevilacqua F, Lucchetti M , Spadoni T., Mancini, M., Fraticelli P., Sambo P, Funaro, A.,Kazlauskas, A., Avvedimento VE*, Gabrielli A* (2006) Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis (scleroderma). New Engl.J.Med, 354(25):2667-76.

Cosentino C, Di Domenico M, Porcellini A, Cuozzo C, De Gregorio G, Santillo MR, Agnese S, Di Stasio R, Feliciello A, Migliaccio A, Avvedimento EV (2007) p85 regulatory subunit of PI3K mediates cAMP-PKA and estrogens biological effects on growth and survival. Oncogene, 26(14):2095-103.

Giorgia De Gregorio, Anna Coppa, Claudia Cosentino, Severine Ucci, Samantha Messina, Arianna Nicolussi, Sonia D"Inzeo, Alba Di Pardo, Enrico V. Avvedimento3, Antonio Porcellini (2007) The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals. Oncogene, 26(14):2039-47.

Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Pardo AD, Messina S, Iuliano R, Fusco A, Santillo MR, Muller MT, Chiariotti L, Gottesman ME, Avvedimento EV (2007) DNA Damage, Homology-Directed Repair, and DNA Methylation. PLoS Gen., vol. 3, pp. 1144-1162.

Perillo B, Ombra MN, Bertoni A, Cuozzo C, Sacchetti S, Sasso A, Chiariotti L, Malorni A, Abbondanza C, Avvedimento EV (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science, 319(5860):202-6.

Gabrielli A, Svegliati S, Moroncini G, Pomponio G, Santillo M, Avvedimento EV (2008) Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited. Semin Immunopathol., 30(3):329-37.

A. Gabrielli, E.V.Avvedimento and T. Krieg (2009) Scleroderma. N.Engl.J. Med., 360:1989-2003

Avvedimento E V and Gabrielli A (2010) Stiff and Tight Skin: a rear window into fibrosis without inflammation. Science Translational Medicine, 2(23):20-23.

Amente S, Lania L, Avvedimento EV, Majello B (2010) DNA oxidation drives Myc mediated transcription.
Cell Cycle, 9(15):3002-4.

Bocchino M, Agnese S, Fagone E, Svegliati S, Grieco D, Vancheri C, Gabrielli A, Sanduzzi A, Avvedimento EV (2010) Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis. PLoS One, 5(11):e14003.

Bertoni A, Giuliano P, Galgani M, Rotoli D, Ulianich L, Adornetto A, Santillo MR, Porcellini A, Avvedimento VE (2011) Early and late events induced by polyq-expanded proteins: identification of a common pathogenic property of polyq-expanded proteins. J Biol Chem., 286(6):4727-41.
Project Title:
Link between DNA methylation and repair.

Project Title:
Transcription and metabolism.