Leonardo Potenza
Leonardo Potenza
affiliation: Università di Modena-Reggio Emilia
research area(s): Immunity And Infection, Cancer Biology
Course: Molecular and Regenerative Medicine
University/Istitution: Università di Modena-Reggio Emilia
Leonardo Potenza is Research Associate in Clinical and Experimental Hematology. He has published more than 50 scientific articles in international journals, including Blood, Leukemia, American Journal of Transplantation and the New England Journal of Medicine, as well as reviews and two book chapters in the field of Haematology. He participated in major project granted by the Italian Ministry of University and Scientific and Technological Research, by the European Commission’s FP6 Life-Science-Health Programme (INCA project; LSHC-CT-2005-018704), by Regione Emilia-Romagna (Programma di ricerca Regione-Università 2007-2009) and by industries and private Associations (Associazione Italiana Lotta alle Leucemie, Linfoma e Mieloma (AIL)-Modena-ONLUS).
At present, working at the Department of Oncology and Hematology, Section of Haematology, directed by Professor Mario Luppi, with both clinical and research responsibilities.
Research Associate in Hematology, since December 2010
PhD in Molecular and Regenerative Medicine at the University of Modena and Reggio Emilia, Modena, in 2009;
Master in Molecular Diagnostics and Therapeutic Choices in Oncology and Hematology with 105/110 at the University of Modena and Reggio Emilia, Modena in 2004
Specialty in Clinical Haematology with 50/50 cum Laude at the University of Modena and Reggio Emilia, Modena, in 2001;
Residency in Haematology and Internal Medicine Branches of the University of Modena and Reggio Emilia, Modena from 1994 to 2001;
Graduation in Medicine & Surgery with 108/110 at the University of Modena and Reggio Emilia, Modena in 1997.
Past recipient of fellowships provided by AIL for the Residency in Haematology.
Applicant with Prof. G. Torelli, Prof. M. Luppi and Dr. P. Barozzi for an International patent regarding clinical application of ELISPOT assay for the diagnosis of Aspergillus infections [n. 07866799.5 (PCT/IT2007/000867)].
Applicant with Prof. M. Luppi, Dr. P. Barozzi, Dr. D. Vallerini and Dr. F. Forghieri for an Italian patent regarding clinical application of ELISPOT assay for the diagnosis of Mucorales infections.
Winner of the national prize of the Italian Association for Cell Culture for experimental observations of particular interest, related to studies on cell cultures in Fungal Infections in 2007
Winner of the national prize of the Italian Society of Eperimental Haematology for experimental observations related to translational studies on leukemic patients in 2008
Winner of the national prize “Pietro Martino” of the Italian Society of Eperimental Haematology for the best project about infectious complications in hematologic patients in 2010.

Dr Potenza developed either expertise in the diagnosis and treatment of acute leukemias or research interests mainly focused on the pathogenesis, diagnosis and treatment of related infectious complications by working at the Section of Hematology headed by Professor Mario Luppi at the University of Modena and Reggio Emilia.
Special areas of research activity include the study of genetic and immunologic risk factors for viral and fungal infections in bone marrow/stem cell and solid organ transplantation, the development and validation of new immunologic tests for the diagnosis and monitoring of infectious agents in at risk immunocompromised patient groups, the study of anti-tumor immune responses in acute leukemia patients undergoing targeted therapy and the investigation of new immuno-therapeutic approaches for virus-related tumors.
1. Potenza L, Barozzi P, Torelli G, Luppi M. (2010) Translational challenges of human herpesvirus 6 chromosomal integration. Future Microbiol;5(7):993-5.
2. Riva G, Luppi M, Barozzi P, Quadrelli C, Basso S, Vallerini D, Zanetti E, Morselli M, Forghieri F, Maccaferri M, Volzone F, Del Giovane C, D'Amico R, Locatelli F, Torelli G, Comoli P, Potenza L. (2010) Emergence of BCR-ABL-specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment. Blood;115(8):1512-8
3. Potenza L, Barozzi P, Masetti M, Pecorari M, Bresciani P, Gautheret-Dejean A, Riva G, Vallerini D, Tagliazucchi S, Codeluppi M, Di Benedetto F, Gerunda GE, Narni F, Torelli G, Luppi M. (2009) Prevalence of human herpesvirus-6 chromosomal integration (CIHHV-6) in Italian solid organ and allogeneic stem cell transplant patients. Am J Transplant. 2009;9(7):1690-7.
4. Barozzi P, Bonini C, Potenza L, Masetti M, Cappelli G, Gruarin P, Whitby D, Gerunda GE, Mondino A, Riva G, Vallerini D, Quadrelli C, Bosco R, Ciceri F, Bordignon C, Schulz TF, Torelli G, Luppi M. (2008) Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcoma. Transplantation;86(5):738-44.
5. Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, Pecorari M, Masetti M, Di Benedetto F, Gennari W, Portolani M, Gerunda GE, Lazzarotto T, Landini MP, Schulz TF, Torelli G, Guaraldi G. (2008) HHV-6A in syncytial giant-cell hepatitis. N Engl J Med;359(6):593-602.
Project Title:
In hematologic patients at high risk for invasive fungal infections, we propose: A. to study the relationship between the presence of specific T cells to different recombinant proteins of Aspergillus and different antigens of Mucorales and the occurrence of invasive diseases from these two fungi;
B. to study the correlation between the phenotypical and functional characteristics of
such T cells, at different phases of the infections, and the outcome of the infections
C. to identify the most effective antigens in eliciting anti-Aspergillus and anti-Mucorales specific T cells.