Andrea Mattevi
Andrea Mattevi
affiliation: Università di Pavia
research area(s): Molecular Biology, Chemical Biology
Course: Biomolecular Sciences and Biotechnology
University/Istitution: Istituto Universitario di Studi Superiori, Pavia
Full Professor of Molecular Biology, University of Pavia

• 1988 University of Pavia (Italy), Biology Degree
• 1988-1992 University of Groningen (Netherlands), PhD
• 1992-1993 MRC-LMB, Cambridge (UK), Post-doc

The common theme to Dr Mattevi's research projects has been the
investigation of medically relevant enzymes with interesting chemical
properties, such as complex multifunctional systems and proteins performing
unusual catalytic functions. The core of the research activity is
represented by X-ray crystallography, employed to study protein
three-dimensional structures. This is, however, complemented by other
approaches such as site-directed mutagenesis, analysis of enzyme kinetics
and computational chemistry.
- Forneris F., Mattevi, A. (2008) Enzymes Without Borders: Mobilizing Substrates, Delivering Products. Science 321, 213-216

- Baron, R., Riley, C., Chenprakhon, P., Thotsaporn, K., Winter, R., Alfieri, A., Forneris, F., van Berkel, W., Chaiyen, P., Fraaije, M.W., Mattevi, A., McCammon, J.A. (2009) Multiple pathways guide oxygen diffusion into flavoenzyme active sites. Proc. Natl. Acad. Sci. USA 106, 10603-10608

- Baron, R., Binda, C., Tortorici, M., McCammon, J.A., Mattevi, A. (2011) Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1 – CoREST Complex. Structure 19, 212-220
Project Title:
Molecular structural biology of a chromatin-modifying protein complex
Our project investigates the molecular mechanisms of epigenetic regulation of gene expression to exploit them as potential targets for anticancer drugs. The proposal stems from our discovery of histone-modifying demethylase enzymes which led to the development of inhibitors of potential relevance for the treatment of leukemia and, more generally, for blocking tumor progression. The project has a twofold goal: (i) to advance our knowledge on the combinatorial assembly of enzyme complexes in the chromatin, and to (ii) to translate this knowledge into chemical tools that will be probed for their antiproliferative activities in cancer models that involve aberrations in chromatin-related processes.