Franco Merletti
Franco Merletti
e-mail:
affiliation: Università di Torino
research area(s): Cancer Biology, Computational Biology
Course: Biomedical Sciences and Human Oncology
University/Istitution: Università di Torino
Full Professor of Medical Statistic - University of Turin, Italy

Director, Unit of Cancer Epidemiology, Dept. Biomedical Sciences & Human Oncology, University of Turin and San Giovanni Battista Hospital, Turin

Coordinator of Reference Center for Epidemiology and Oncological Prevention (CPO Piemonte)
International Studies

Birth cohorts
-Feasibility of recruiting a birth cohort through the Internet: the NINFEA cohort

Childhood Cancer
-Effects of maternal age and cohort of birth on incidence time trends of childhood acute lymphoblastic leukemia
-Parental age and risk of acute lymphocytic leukaemia and embryonal tumours in the Piedmont Region, Italy
-Risk of second malignant neoplasms after childhood leukemia and lymphoma

Life-style factors
-Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection
-Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study
-Socioeconomic factors associated with risk of upper aerodigestive tract cancer in Europe
-Active and involuntary tobacco smoking and upper-aerodigestive-tract cancer risks in a multicenter case-control study

Molecular Epidemiology
-Efficiency of DNA extraction from 25-year-old paraffin-embedded tissues: study of 365 samples
-Association between hypermethylated tumor and paired surgical margins in head and neck squamous cell carcinomas
-Hypermethylation, risk factors, clinical characteristics, and survival in patients with laryngeal and hypopharyngeal cancers
-N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA
-Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project
-Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
-Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract
-A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
-Multiple ADH genes are associated with upper aerodigestive cancers

Occupational Epidemiology
-Lung cancer risk in painters: a meta-analysis
-Bladder cancer risk in painters: a meta-analysis

Rare Cancers
-Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle
-Occupational exposure to endocrine-disrupting compounds and biliary tract cancer among men
-Time trends in the incidence of testicular cancer in childhood and young adulthood

Methodological Studies
-Semi-Bayes and empirical Bayes adjustment methods for multiple comparisons
-Computing hospitalization rates in presence of repeated events: impact and countermeasures to avoid misinterpretation
-A high positive predictive value algorithm using hospital administrative data identified incident cancer cases
-Using directed acyclic graphs to consider adjustment for socioeconomic status in occupational cancer studies
-Information on Center Characteristics as Costs' Determinants in Multicenter Clinical Trials: Is Modeling Center Effect Worth the Effort?
-Survival models for cost data: the forgotten additive approach
-Extreme regression models for characterizing high-cost patients


National Studies

Childhood Cancer
-Expected number of childhood cancers in Italy from 2001 to 2015
-Mortality from cancer and other causes in parents of children with cancer in Piedmont
-Avoided deaths as an indicator of improvement of childhood cancer treatment
-Health-related quality of life of long-term childhood cancer survivors in Piedmont
-Analysis of nonresponse in the assessment of health-related quality of life of childhood cancer survivors
-High incidence of acute promyelocytic leukemia in children in northwest Italy, 1980-2003: a report from the Childhood Cancer Registry of Piedmont
-Cause of mortality in five-year survivors of childhood cancer in North-West Italy, 1967-1999
-Survival of children with cancer in Italy, 1989-98
-Patterns of domestic migrations and access to childhood cancer care centres in Italy

Adolescents with cancer in Italy
-Life after childhood cancer: marriage and offspring in adult long-term survivors in Piedmont
-Clinical Epidemiology
-Accessibility as a major determinant of radiotherapy underutilization: a population based study in Piedmont
-Study and Prevention of Neonatal Fungal Infections in preterm neonates
-Continuous positive airway pressure for treatment of respiratory complications after abdominal surgery: a systematic review and meta-analysis
-Cardiovascular benefits of smoking regulations: The effect of decreased exposure to passive smoking
-Monitoring the performance of intensive care units using the variable life-adjusted display: a simulation study to explore its applicability and efficiency
-Appropriateness of early breast cancer management in relation to patient and hospital characteristics

Molecular Epidemiology
-SYBR Green methodology for simultaneous screening and quantification of human papillomavirus
-Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients
-Occult HCV infection: an unexpect finding in a population unselected for hepatic disease
About 330 publications, 220 indexed in MEDLINE.
IF total = 1024.107
Cumulative citation index: 3998
H-index factor: 32

McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Voodern T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P. Correction: A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. PLoS Genet. 2011 Apr;7(4).
Maule M, Scélo G, Pastore G, Brennan P, Hemminki K, Olsen JH, Tracey E, Pukkala E, Weiderpass E, Brewster DH, Tamaro S, Chia KS, Pompe-Kirn V, Kliewer EV, Tonita JM, Martos C, Jonasson JG, Merletti F, Boffetta P. Second malignancies after childhood non-central nervous system solid cancer: Results from 13 cancer registries. Int J Cancer. 2011 Apr 25
McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Voodern T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet. 2011 Mar;7(3):e1001333.
Barone-Adesi F, Gasparrini A, Vizzini L, Merletti F, Richiardi L. Effects of Italian smoking regulation on rates of hospital admission for acute coronary events: a country-wide study. PLoS One. 2011 Mar 2;6(3):e17419.
Pivetta E, Maule MM, Pisani P, Zugna D, Haupt R, Jankovic M, Aricò M, Casale F, Clerico A, Cordero di Montezemolo L, Kiren V, Locatelli F, Palumbo G, Pession A, Pillon M, Santoro N, Terenziani M, Valsecchi MG, Dama E, Magnani C, Merletti F, Pastore G; for the Italian Association of Pediatric Hematology and Oncology (AIEOP) Group. Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP Off-Therapy Registry. Haematologica. 2011 May;96(5):744-751.
Park SL, Lee YC, Marron M, Agudo A, Ahrens W, Barzan L, Bencko V, Benhamou S, Bouchardy C, Canova C, Castellsague X, Conway DI, Healy CM, Holcátová I, Kjaerheim K, Lagiou P, Lowry RJ, Macfarlane TV, Macfarlane GJ, McCartan BE, McKinney PA, Merletti F, Pohlabeln H, Richiardi L, Simonato L, Sneddon L, Talamini R, Trichopoulos D, Znaor A, Brennan P, Hashibe M. The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study. Int J Cancer. 2011 Mar 15;128(6):1449-61
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