A. Education
1981 M.D. degree University of Modena
1985 Specialty in Gastroenterology University of Modena
1989 Ph.D. degree University of Modena

B. Positions and Employment.
1988-1989 Research Associate, Institute of General Pathology University of Milan (Mentor: Prof. Dr. A. Bernelli-Zazzera).
1989 Assistant Professor of Medicine, Department of Medicine, University of Modena.
1989-1991 “Research Associate”, Liver Research Center, Albert Einstein College of Medicine, New York, USA
1991-1993 Visiting Assistant Professor, Department of Internal Medicine, Liver Research Center, Albert Einstein College of Medicine, New York, USA
2001 Professor of Medicine, University of Modena and Reggio Emilia.
2009 Director, Division of Internal Medicine 2 & Center for Hemochromatosis, University Hospital of Modena.
2010 Director "Mario Coppo" Center for Advanced Research in Hepatology

C. Other Experience, Professional Memberships
1995 President of the International Association for the Study of Disorders of Iron Metabolism, Boston, USA, April 1995.
1996 International Investigator Award, Geneva, Switzerland. European Association for the Study of the Liver (EASL).
1997 Member of the International Scientific Committee of the Fifth Conference of the International Association for the Study of Disorders of Iron Metabolism, 16-20 June 1997, Saint-Malo, France.
1997 President of the International Association for the Study of Disorders of Iron Metabolism
1998 Member of the Scientific Committee of the European Association for the Study of the Liver
2001 Chair, Founding Committee of the International Bioiron Society.
2003 President, International Bioiron Society (IBIS), Boston, USA.

D. Honors
1989 NATO-CNR Advanced Fellowship Award.
1990 Fogarty International Fellowship Award.
1993 International Young Investigator Award, Paris, France. European Association for the Study of the Liver (EASL).
1995 Marcel Simon Award for Excellence in Research in Disorders of Iron Metabolism, Boston, USA. International Association for the Study of Disorders of Iron Metabolism (IASDIM).

1. Molecular regulation of iron metabolism: transcriptional control of hepcidin, the iron hormone, in physiology and pathophysiology
2. Molecular pathogenesis of hereditary hemochromatosis using knock-out and transgenic animal models
2. Genetics, genotype-phenotype studies and epidemiology of hereditary hemochromatosis

1. A. PIETRANGELO, J. ROY-CHOWDHURY, D.A. SHAFRITZ. Albumin gene expression is down-modu-lated by albumin and macromolecule infusion in the rat. J Clin Invest, 89:1755-1760;1992.
2. G. CAIRO, A. PIETRANGELO. Transferrin-receptor gene expression during rat liver regeneration: evi¬dence for posttranscriptional regulation by IRFB, a second IRE binding protein. J Biol Chem, 269:6405-6409,1994.
3. A. PIETRANGELO, D.A. SHAFRITZ. Oncotically active macromolecules modulate hepatocyte nuclear factor-1 activity in cultured hepatoma cells. P Natl Acad Sci USA, 91:182-186,1994.
4. S. BAI, A. SCHOENFELD, A. PIETRANGELO, R.D. BURK. Basal promoter of the rat connexin 32 gene: Identification and characterization of an essential element and its DNA-binding protein Mol Cell Biol, 15:1439-1445, 1995.
5. A. PIETRANGELO, R. GUALDI, G. CASALGRANDI, G. MONTOSI, E. VENTURA. Molecular aspects of liver fibrogenesis during iron overload in rodents. J Clin Invest, 95:1824-1831, 1995.
6. C. TRAUTWEIN, A. PIETRANGELO, G. MONTOSI, T. RAKEMAN, J. PLUMPE, M.P. MANNS. C/EBP-bLAP controls down-regulation of albumin gene expression during liver regeneration. J Biol Chem, 271: 22262-70, 1996.
7. H. ZOLLER, A. PIETRANGELO, W. VOGEL, G. WEISS. Increased expression of the duodenal metal transporter NRAMP-2 in patients with hereditary hemochromatosis. Lancet, 353:2120-2123, 1999.
8. A. PIETRANGELO, G. MONTOSI, C. GARUTI, S. CASSANELLI, D. CONTE, M. FRAQUELLI, P. GASPARINI. Hereditary Hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene. New Engl J Med, 341:725-731, 1999.
9. G. MONTOSI, A. DONOVAN, A. TOTARO, C. GARUTI, E. PIGNATTI, S. CASSANELLI, C.C. TRENOR, P. GASPARINI, N. C. ANDREWS, A. PIETRANGELO. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest, 108 (4): 619-623, 2001.
10. A. PIETRANGELO. Hereditary hemochromatosis: a new look at an old disease. New Engl J Med, 350:2383-97, 2004.
11. PIETRANGELO A, DIERSSEN U, VALLI L, GARUTI C, RUMP A, CORRADINI E, ERNST M, KLEIN C, TRAUTWEIN C. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology, 132(1):294-300, 2007.
12. ANDRIOPOULOS B, JR, CORRADINI E, XIA Y, FAASSE SA, CHEN S, GRGUREVIC L, KNUTSON MD, PIETRANGELO A., VUKICEVIC S, LIN HY, BABITT JL. BMP-6 is a Key Endogenous Regulator of Hepcidin Expression and Iron Metabolism. Nat Genet, 41(4):482-7, 2009.
13. VECCHI C, MONTOSI G, ZHANG KZ, LAMBERTI I, DUNCAN SA, KAUFMAN RJ, PIETRANGELO A. ER Stress Controls Iron Metabolism Through Induction of Hepcidin. Science, 325(5942): 877-880, 2009.
14. GARUTI C, TIAN Y, MONTOSI G, SABELLI M, CORRADINI E, GRAF R, VENTURA P, VEGETTI A, CLAVIEN PA, PIETRANGELO A. Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation. Gastroenterology, 139(1): 315-22, 2010.

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