Carmine Nappi
e-mail: nappi AT unina.it
website: www.unina.it
affiliation: Università di Napoli Federico II
research area(s): Neuroscience
Courses:
- Genetics and Molecular Medicine
- Neurosciences
- Molecular Oncology and Endocrinology
- Molecular Pathology and Pathophysiology
Prof. Carmine Nappi was born in Pomigliano D’Arco (Italy) on 2/9/1947.
He graduated in Medicine at the University of Naples, Italy in 1971
In 1990 he became Professore Ordinario of Gynaecological Endocrinology at the Faculty of Medicine of the University of Turin.
In 1994 he became Professore Ordinario of Obstetrics and Gynaecology at the University “Federico II” of Naples.
His main scientifical and clinical interests are in the fields of Reproductive Endocrinology, Oncology and Mininvasive surgery.
He is author of more than 400 scientific papers on italian and international journals.
He has been principal investigators in several international clinical trials in GCP and has coordinated several national research projects..
At present he is Head of the Clinical Department of Obstetrics, Gynaecology and Urology of the University Hospital at the University of Naples Federico II.
He has been President of the Italian Society of Menopause in the years 1998 and 1999, President of the Italian Society of Reproductive Physiopathology from 2000 to 2005 and President of the Italian Society of Contraception from 2008 to 2010.
He graduated in Medicine at the University of Naples, Italy in 1971
In 1990 he became Professore Ordinario of Gynaecological Endocrinology at the Faculty of Medicine of the University of Turin.
In 1994 he became Professore Ordinario of Obstetrics and Gynaecology at the University “Federico II” of Naples.
His main scientifical and clinical interests are in the fields of Reproductive Endocrinology, Oncology and Mininvasive surgery.
He is author of more than 400 scientific papers on italian and international journals.
He has been principal investigators in several international clinical trials in GCP and has coordinated several national research projects..
At present he is Head of the Clinical Department of Obstetrics, Gynaecology and Urology of the University Hospital at the University of Naples Federico II.
He has been President of the Italian Society of Menopause in the years 1998 and 1999, President of the Italian Society of Reproductive Physiopathology from 2000 to 2005 and President of the Italian Society of Contraception from 2008 to 2010.
Reproductive medicine:
Postmenopausal hormone replacement therapy
Contraception
Miniinvasive surgery:
Mini-invasive surgery for the treatment of urinary stress incontinence
Laparoscopic treatment of gynecological diseases
Office hysteroscopy in the treatment of uterine diseases
Oncology:
Surgical treatment of gynecological neoplasms
Postmenopausal hormone replacement therapy
Contraception
Miniinvasive surgery:
Mini-invasive surgery for the treatment of urinary stress incontinence
Laparoscopic treatment of gynecological diseases
Office hysteroscopy in the treatment of uterine diseases
Oncology:
Surgical treatment of gynecological neoplasms
1: Savoia F, Ferrara C, Sansone A, Bifulco G, Nappi C, Di Carlo C. Portal
Cavernoma during Pregnancy. Case Rep Obstet Gynecol. 2013;2013:396083. doi:
10.1155/2013/396083. Epub 2013 Dec 10. PubMed PMID: 24392231.
2: Milone M, Musella M, Di Spiezio Sardo A, Bifulco G, Salvatore G, Sosa
Fernandez LM, Bianco P, Zizolfi B, Nappi C, Milone F. Video-assisted ablation of
pilonidal sinus: A new minimally invasive treatment-A pilot study. Surgery. 2013
Oct 25. pii: S0039-6060(13)00479-0.
3: Paladini D, Quarantelli M, Sglavo G, Pastore G, Cavallaro A, D'Armiento,
Salvatore M, Nappi C. The role of MRI in the clinical management of foetuses with central nervous system abnormalities in a tertiary referral center. Ultrasound
Obstet Gynecol. 2013 Nov 1.
4: Di Carlo C, Sansone A, De Rosa N, Gargano V, Tommaselli GA, Nappi C, Bifulco
G. Impact of an implantable steroid contraceptive (etonogestrel-releasing
implant) on quality of life and sexual function: a preliminary study. Gynecol
Endocrinol. 2014 Jan;30(1):53-6.
5: Di Carlo C, Iannotti G, Sparice S, Chiacchio MP, Greco E, Tommaselli GA, Nappi C. The role of a personalized dietary intervention in managing gestational weight gain: a prospective, controlled study in a low-risk antenatal population. Arch
Gynecol Obstet. 2013 Oct 16.
6: Di Carlo C, Gargano V, Sparice S, Tommaselli GA, Bifulco G, Nappi C. Effects
of an oral contraceptive containing estradiol valerate and dienogest on
circulating androgen levels and acne in young patients with PCOS: an
observational preliminary study. Gynecol Endocrinol. 2013 Dec;29(12):1048-50.
7: Di Carlo C, Savoia F, Gargano V, Sparice S, Bifulco G, Nappi C. Successful
pregnancy complicated by spontaneous, familial, recurrent ovarian
hyperstimulation syndrome: report of two cases. Gynecol Endocrinol. 2013
Oct;29(10):897-900.
8: Marra ML, Zullo F, De Felice B, Nappi L, Guida M, Trifuoggi M, Nappi C, Di
Spiezio Sardo A, Zizolfi B, Capece G, Visconti F, Troisi J, Ciccone C, Guida M.
Environmental pollution effects on reproductive health - clinical-epidemiological study in southern Italy. Transl Med UniSa. 2012 Oct 11;4:39-56.
9: Milone M, Di Minno MN, Bifulco G, Maietta P, Sosa Fernandez LM, Musella M,
Iaccarino V, Buccelli C, Nappi C, Milone F. Diagnostic value of abdominal free
air detection on a plain chest radiograph in the early postoperative period: a
prospective study in 648 consecutive patients who have undergone abdominal
surgery. J Gastrointest Surg. 2013 Sep;17(9):1673-82.
10: DeCensi A, Bonanni B, Maisonneuve P, Serrano D, Omodei U, Varricchio C,
Cazzaniga M, Lazzeroni M, Rotmensz N, Santillo B, Sideri M, Cassano E, Belloni C,Muraca M, Segnan N, Masullo P, Costa A, Monti N, Vella A, Bisanti L, D'Aiuto G,
Veronesi U; Italian HOT Study Group. A phase-III prevention trial of low-dose
tamoxifen in postmenopausal hormone replacement therapy users: the HOT study. Ann Oncol. 2013 Nov;24(11):2753-60.
11: Di Carlo C, Gargano V, Sparice S, Tommaselli GA, Bifulco G, Schettino D,
Nappi C. Short-term effects of an oral contraceptive containing oestradiol
valerate and dienogest on bone metabolism and bone mineral density: an
observational, preliminary study. Eur J Contracept Reprod Health Care. 2013
Oct;18(5):388-93.
12: Paladini D, Pastore G, Cavallaro A, Massaro M, Nappi C. Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age.
Ultrasound Obstet Gynecol. 2013 Dec;42(6):687-90.
13: Di Spiezio Sardo A, Paladini D, Zizolfi B, Spinelli M, Nappi C. Pentalogy of Cantr ll: embryofetoscopic diagnosis. J Minim Invasive Gynecol. 2013
Mar-Apr;20(2):248-51.
14: Tommaselli GA, D'Afiero A, Di Carlo C, Formisano C, Fabozzi A, Nappi C.
Tension-free vaginal tape-O and -Secur for the treatment of stress urinary
incontinence: a thirty-six-month follow-up single-blind, double-arm, randomized
study. J Minim Invasive Gynecol. 2013 Mar-Apr;20(2):198-204.
15: Tommaselli GA, D'Afiero A, Di Carlo C, Formisano C, Fabozzi A, Nappi C.
Efficacy of a modified technique for TVT-O positioning: a twelve-month,
randomized, single-blind, multicenter, non-inferiority study. Eur J Obstet
Gynecol Reprod Biol. 2013 Apr;167(2):225-9
16: Nappi L, Di Spiezio Sardo A, Spinelli M, Guida M, Mencaglia L, Greco P, Nappi C, Filippeschi M, Florio P. A multicenter, double-blind, randomized,
placebo-controlled study to assess whether antibiotic administration should be
recommended during office operative hysteroscopy. Reprod Sci. 2013
Jul;20(7):755-61.
17: Di Spiezio Sardo A, Alviggi C, Zizolfi B, Spinelli M, De Rosa P, De Placido
G, Nappi C. Cervico-isthmic pregnancy successfully treated with bipolar resection following methotrexate administration: case report and literature review. Reprod Biomed Online. 2013 Jan;26(1):99-103
18: Tommaselli GA, Di Carlo C, Formisano C, Fabozzi A, Nappi C. Vaginal delivery following single incision sling (TVT-Secur) for female stress urinary
incontinence. J Obstet Gynaecol Res. 2013 Feb;39(2):608-10
Cavernoma during Pregnancy. Case Rep Obstet Gynecol. 2013;2013:396083. doi:
10.1155/2013/396083. Epub 2013 Dec 10. PubMed PMID: 24392231.
2: Milone M, Musella M, Di Spiezio Sardo A, Bifulco G, Salvatore G, Sosa
Fernandez LM, Bianco P, Zizolfi B, Nappi C, Milone F. Video-assisted ablation of
pilonidal sinus: A new minimally invasive treatment-A pilot study. Surgery. 2013
Oct 25. pii: S0039-6060(13)00479-0.
3: Paladini D, Quarantelli M, Sglavo G, Pastore G, Cavallaro A, D'Armiento,
Salvatore M, Nappi C. The role of MRI in the clinical management of foetuses with central nervous system abnormalities in a tertiary referral center. Ultrasound
Obstet Gynecol. 2013 Nov 1.
4: Di Carlo C, Sansone A, De Rosa N, Gargano V, Tommaselli GA, Nappi C, Bifulco
G. Impact of an implantable steroid contraceptive (etonogestrel-releasing
implant) on quality of life and sexual function: a preliminary study. Gynecol
Endocrinol. 2014 Jan;30(1):53-6.
5: Di Carlo C, Iannotti G, Sparice S, Chiacchio MP, Greco E, Tommaselli GA, Nappi C. The role of a personalized dietary intervention in managing gestational weight gain: a prospective, controlled study in a low-risk antenatal population. Arch
Gynecol Obstet. 2013 Oct 16.
6: Di Carlo C, Gargano V, Sparice S, Tommaselli GA, Bifulco G, Nappi C. Effects
of an oral contraceptive containing estradiol valerate and dienogest on
circulating androgen levels and acne in young patients with PCOS: an
observational preliminary study. Gynecol Endocrinol. 2013 Dec;29(12):1048-50.
7: Di Carlo C, Savoia F, Gargano V, Sparice S, Bifulco G, Nappi C. Successful
pregnancy complicated by spontaneous, familial, recurrent ovarian
hyperstimulation syndrome: report of two cases. Gynecol Endocrinol. 2013
Oct;29(10):897-900.
8: Marra ML, Zullo F, De Felice B, Nappi L, Guida M, Trifuoggi M, Nappi C, Di
Spiezio Sardo A, Zizolfi B, Capece G, Visconti F, Troisi J, Ciccone C, Guida M.
Environmental pollution effects on reproductive health - clinical-epidemiological study in southern Italy. Transl Med UniSa. 2012 Oct 11;4:39-56.
9: Milone M, Di Minno MN, Bifulco G, Maietta P, Sosa Fernandez LM, Musella M,
Iaccarino V, Buccelli C, Nappi C, Milone F. Diagnostic value of abdominal free
air detection on a plain chest radiograph in the early postoperative period: a
prospective study in 648 consecutive patients who have undergone abdominal
surgery. J Gastrointest Surg. 2013 Sep;17(9):1673-82.
10: DeCensi A, Bonanni B, Maisonneuve P, Serrano D, Omodei U, Varricchio C,
Cazzaniga M, Lazzeroni M, Rotmensz N, Santillo B, Sideri M, Cassano E, Belloni C,Muraca M, Segnan N, Masullo P, Costa A, Monti N, Vella A, Bisanti L, D'Aiuto G,
Veronesi U; Italian HOT Study Group. A phase-III prevention trial of low-dose
tamoxifen in postmenopausal hormone replacement therapy users: the HOT study. Ann Oncol. 2013 Nov;24(11):2753-60.
11: Di Carlo C, Gargano V, Sparice S, Tommaselli GA, Bifulco G, Schettino D,
Nappi C. Short-term effects of an oral contraceptive containing oestradiol
valerate and dienogest on bone metabolism and bone mineral density: an
observational, preliminary study. Eur J Contracept Reprod Health Care. 2013
Oct;18(5):388-93.
12: Paladini D, Pastore G, Cavallaro A, Massaro M, Nappi C. Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age.
Ultrasound Obstet Gynecol. 2013 Dec;42(6):687-90.
13: Di Spiezio Sardo A, Paladini D, Zizolfi B, Spinelli M, Nappi C. Pentalogy of Cantr ll: embryofetoscopic diagnosis. J Minim Invasive Gynecol. 2013
Mar-Apr;20(2):248-51.
14: Tommaselli GA, D'Afiero A, Di Carlo C, Formisano C, Fabozzi A, Nappi C.
Tension-free vaginal tape-O and -Secur for the treatment of stress urinary
incontinence: a thirty-six-month follow-up single-blind, double-arm, randomized
study. J Minim Invasive Gynecol. 2013 Mar-Apr;20(2):198-204.
15: Tommaselli GA, D'Afiero A, Di Carlo C, Formisano C, Fabozzi A, Nappi C.
Efficacy of a modified technique for TVT-O positioning: a twelve-month,
randomized, single-blind, multicenter, non-inferiority study. Eur J Obstet
Gynecol Reprod Biol. 2013 Apr;167(2):225-9
16: Nappi L, Di Spiezio Sardo A, Spinelli M, Guida M, Mencaglia L, Greco P, Nappi C, Filippeschi M, Florio P. A multicenter, double-blind, randomized,
placebo-controlled study to assess whether antibiotic administration should be
recommended during office operative hysteroscopy. Reprod Sci. 2013
Jul;20(7):755-61.
17: Di Spiezio Sardo A, Alviggi C, Zizolfi B, Spinelli M, De Rosa P, De Placido
G, Nappi C. Cervico-isthmic pregnancy successfully treated with bipolar resection following methotrexate administration: case report and literature review. Reprod Biomed Online. 2013 Jan;26(1):99-103
18: Tommaselli GA, Di Carlo C, Formisano C, Fabozzi A, Nappi C. Vaginal delivery following single incision sling (TVT-Secur) for female stress urinary
incontinence. J Obstet Gynaecol Res. 2013 Feb;39(2):608-10
Project Title:
Role of the unfolded protein response in the progression and chemo-radiosensitivity of endometrial tumors
The role of ER stress, UPR induction and BiP/Grp78 in the development and progression
of endometrial tumors, as their role in resistance to therapies, have never been
investigated. Our preliminary data indicate that, as reported in breast, prostate, gastric and
colon carcinomas, BiP/Grp78 is overexpressed also in endometrial carcinomas. Thus, ER
stress, UPR induction and BiP/Grp78 may play an important role in these tumors. This
hypothesis needs to be further confirmed and the molecular mechanisms identified. With
this background, the proposed project will pursue the following three major objectives.
_ To elucidate the role of ER stress, UPR signalling and BiP/Grp78 in endometrial
tumors development and progression both in vitro and in vivo.
_ To define the significance of ER stress, UPR signalling and BiP/Grp78 to invasion
and metastasis both in vitro and in vivo;
_ To define the significance of ER stress, UPR signalling and BiP/Grp78, to
radio/chemoresistance both in vitro and in vivo, improving therapeutic strategies.
Understanding the role of ER stress, UPR induction and BiP/Grp78 in the development
and progression of endometrial tumors, as their role in resistance to therapies, as
described in the next section, is expected to generate novel and valuable information for
identifying novel targets for prevention and therapy of endometrial cancer.
of endometrial tumors, as their role in resistance to therapies, have never been
investigated. Our preliminary data indicate that, as reported in breast, prostate, gastric and
colon carcinomas, BiP/Grp78 is overexpressed also in endometrial carcinomas. Thus, ER
stress, UPR induction and BiP/Grp78 may play an important role in these tumors. This
hypothesis needs to be further confirmed and the molecular mechanisms identified. With
this background, the proposed project will pursue the following three major objectives.
_ To elucidate the role of ER stress, UPR signalling and BiP/Grp78 in endometrial
tumors development and progression both in vitro and in vivo.
_ To define the significance of ER stress, UPR signalling and BiP/Grp78 to invasion
and metastasis both in vitro and in vivo;
_ To define the significance of ER stress, UPR signalling and BiP/Grp78, to
radio/chemoresistance both in vitro and in vivo, improving therapeutic strategies.
Understanding the role of ER stress, UPR induction and BiP/Grp78 in the development
and progression of endometrial tumors, as their role in resistance to therapies, as
described in the next section, is expected to generate novel and valuable information for
identifying novel targets for prevention and therapy of endometrial cancer.