Lucio Santoro
e-mail: Lucio.santoro AT unina.it
website: www.unina.it
affiliation: Università di Napoli Federico II
research area(s): Neuroscience
Course:
Neurosciences
University/Istitution: Università di Napoli Federico II
University/Istitution: Università di Napoli Federico II
Prof. Lucio Santoro
Born in Salerno on June 15, 1950.
Medical degree at University of Naples in 1974.
Board certification in Neurology at the same University in 1979 and in Clinical Neurophysiology at the University of Messina in 1985.
Assistant Professor at the Department of Neurology at Federico II University , Naples, since 1980.
Associate Professor of Neurology since 1992.
Head of the Section of Neurophysiology since 1995.
1986-87 Fellow of Research at Department of Neurology of University of Pennsylvania.
Full Professor of Neurology since 2001.
Head of the Section of Clinical Neurology since 2003.
President of Italian Society of Clinical Neurophysiology for years 2004-2006.
Head of the Department of Neurological Sciences at Federico II University of Naples since 2009.
Main fields of research are neurophysiologic studies of acquired and inherited neuropathies, Friedreich’s ataxia and dominant ataxias, morphometric evaluation of cutaneous innervation in neurodegenerative disorders and genetic neuropathies, muscular dystrophies.
He published 210 papers on international journals (pubmed online, ISI).
Born in Salerno on June 15, 1950.
Medical degree at University of Naples in 1974.
Board certification in Neurology at the same University in 1979 and in Clinical Neurophysiology at the University of Messina in 1985.
Assistant Professor at the Department of Neurology at Federico II University , Naples, since 1980.
Associate Professor of Neurology since 1992.
Head of the Section of Neurophysiology since 1995.
1986-87 Fellow of Research at Department of Neurology of University of Pennsylvania.
Full Professor of Neurology since 2001.
Head of the Section of Clinical Neurology since 2003.
President of Italian Society of Clinical Neurophysiology for years 2004-2006.
Head of the Department of Neurological Sciences at Federico II University of Naples since 2009.
Main fields of research are neurophysiologic studies of acquired and inherited neuropathies, Friedreich’s ataxia and dominant ataxias, morphometric evaluation of cutaneous innervation in neurodegenerative disorders and genetic neuropathies, muscular dystrophies.
He published 210 papers on international journals (pubmed online, ISI).
Main fields of research are neurophysiologic studies of acquired and inherited neuropathies, Friedreich’s ataxia and dominant ataxias, morphometric evaluation of cutaneous innervation in neurodegenerative disorders and genetic neuropathies, muscular dystrophies.
He published 210 papers on international journals (pubmed online, ISI).
He published 210 papers on international journals (pubmed online, ISI).
PAREYSON D, REILLY MM, SCHENONE A, FABRIZI GM, CAVALLARO T, SANTORO L, VITA G, QUATTRONE A, PADUA L, GEMIGNANI F, VISIOLI F, LAUR" M, RADICE D, CALABRESE D, HUGHES RA, SOLARI A; CMT-TRIAAL; CMT-TRAUK GROUPS. (2011). Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial.. LANCET NEUROLOGY. pp.:320-328
MANGANELLI F, DUBBIOSO R, NOLANO M, IODICE R, PISCIOTTA C, PROVITERA V, RUGGIERO L, SERLENGA L, BARBIERI F, SANTORO L. (2011). Autoimmune autonomic ganglionopathy: a possible postganglionic neuropathy. ARCHIVES OF NEUROLOGY. pp.:504-507
SANTORO L, BREEDVELD GJ, MANGANELLI F, IODICE R, PISCIOTTA C, NOLANO M, PUNZO F, QUARANTELLI M, PAPPAT" S, DI FONZO A, OOSTRA BA, BONIFATI V. (2011). Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability.. NEUROGENETICS. pp.:33-39
MANGANELLI F, PISCIOTTA C, DUBBIOSO R, IODICE R, CRISCUOLO C, RUGGIERO L, DE MICHELE G, SANTORO L. (2011). Electrophysiological characterisation in hereditary spastic paraplegia type 5.. CLINICAL NEUROPHYSIOLOGY. pp.:819-822
PISCIOTTA C, MANGANELLI F, DUBBIOSO R, RUGGIERO L, IODICE R, SANTORO L. (2011). Thermosensitive hereditary neuropathy with liability to pressure palsy.. MUSCLE & NERVE. pp.:448-449
CARSANA A, FRISSO G, INTRIERI M, TREMOLATERRA MR, SAVARESE G, SCAPAGNINI G, ESPOSITO G, SANTORO L, SALVATORE F (2010). A 15-year molecular analysis of DMD/BMD: genetic features in a large cohort. FRONTIERS IN BIOSCIENCE. pp. 12:547-558
LAMPERTI C, FABBRI G, VERCELLI L, D'AMICO R, FRUSCIANTE R, BONIFAZI E, FIORILLO C, BORSATO C, CAO M, SERVIDA M, GRECO F, DI LEO R, VOLPI L, MANZOLI C, CUDIA P, PASTORELLO E, RICCIARDI L, SICILIANO G, GALLUZZI G, RODOLICO C, SANTORO L, TOMELLERI G, ANGELINI C, RICCI E, PALMUCCI L, MOGGIO M, TUPLER R. (2010). A standardized clinical evaluation of patients affected by facioscapulohumeral muscular dystrophy: The FSHD clinical score. . MUSCLE & NERVE. pp. 5:213-217
ESTRANEO A, MORETTA P, LORETO V, LANZILLO B, SANTORO L, TROJANO L. (2010). Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. . NEUROLOGY. pp. 7:239-245
NOLANO M, DONADIO V, PROVITERA V, SANTORO L. (2010). Possible contribution of vascular innervation to somatic sensory function. . PAIN. pp. 2:552-553
NOLANO M, PROVITERA V, CAPORASO G, STANCANELLI A, VITALE DF, SANTORO L. (2010). Quantification of pilomotor nerves: a new tool to evaluate autonomic involvement in diabetes.. NEUROLOGY. pp. 9:1089-1097
CARSANA A., FRISSO G., INTRIERI M., TREMOLATERRA M.R., SAVARESE G., SCAPAGNINI G., ESPOSITO G., SANTORO L., SALVATORE F (2010). A 15-year molecular analysis of Duchenne/Becker muscular dystrophy: genetic features in a large cohort. FRONTIERS IN BIOSCIENCE. pp. 12:547-558
PROVITERA V, NOLANO M, CAPORASO G, STANCANELLI A, SANTORO L, KENNEDY WR. (2010). Evaluation of sudomotor function in diabetes using the dynamic sweat test.. NEUROLOGY. pp. 7:50-56
NOLANO M, PROVITERA V, SANTORO L. (2010). Internodal length variability of dermal myelinated fibres.. BRAIN. pp. 2:1-2
SANTORO L, NOLANO M, FARASO S, FIORILLO C, VITIELLO C, PROVITERA V, AURINO S, NIGRO V. (2010). Perioral skin biopsy to study skeletal muscle protein expression.. MUSCLE & NERVE. pp. 7:392-398
PISCIOTTA C, MANGANELLI F, IODICE R, BELLONE E, GEROLDI A, VOLPI N, MANDICH P, SANTORO L. (2009). Two families with novel PMP22 point mutations: genotype-phenotype correlation.. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. pp. 5:208-212
MANGANELLI F, VITALE C, SANTANGELO G, PISCIOTTA C, IODICE R, COZZOLINO A, DUBBIOSO R, PICILLO M, BARONE P, SANTORO L. (2009). Functional involvement of central cholinergic circuits and visual hallucinations in Parkinson's disease. BRAIN. pp. 6:2350-2355
PADUA L, BRIANI C, JANN S, NOBILE-ORAZIO E, PAZZAGLIA C, MORINI A, MONDELLI M, CIARAMITARO P, CAVALETTI G, COCITO D, FAZIO R, SANTORO L, GALEOTTI F, CARPO M, PLASMATI R, BENEDETTI L, SCHENONE A, MARCHETTINI P, CRUCCU G. (2009). Validation of the Italian version of the Neuropathic Pain Symptom Inventory in peripheral nervous system diseases. NEUROLOGICAL SCIENCES. pp. 8:99-106
MARTINO D, MACEROLLO A, ABBRUZZESE G, BENTIVOGLIO AR, BERARDELLI A, ESPOSITO M, FABBRINI G, GIRLANDA P, GUIDUBALDI A, LIGUORI R, LIUZZI D, MARINELLI L, MORGANTE F, SABETTA A, SANTORO L, DEFAZIO G. (2009). Lower limb involvement in adult-onset primary dystonia: frequency and clinical features. EUROPEAN JOURNAL OF NEUROLOGY. pp. 5:1-5
MANGANELLI F, PISCIOTTA C, IODICE R, CALANDRO S, DUBBIOSO R, RANIERI A, SANTORO L. (2009). Case of acute motor conduction block neuropathy (AMCBN).. MUSCLE & NERVE. pp.:224-226
SOLARI A, LAUR" M, SALSANO E, RADICE D, PAREYSON D; ON BEHALF OF THE CMT-TRIAAL STUDY GROUP (2008). Reliability of clinical outcome measures in Charcot-Marie-Tooth disease. . NEUROMUSCULAR DISORDERS. pp. 7:19-26
MANGANELLI F, DUBBIOSO R, NOLANO M, IODICE R, PISCIOTTA C, PROVITERA V, RUGGIERO L, SERLENGA L, BARBIERI F, SANTORO L. (2011). Autoimmune autonomic ganglionopathy: a possible postganglionic neuropathy. ARCHIVES OF NEUROLOGY. pp.:504-507
SANTORO L, BREEDVELD GJ, MANGANELLI F, IODICE R, PISCIOTTA C, NOLANO M, PUNZO F, QUARANTELLI M, PAPPAT" S, DI FONZO A, OOSTRA BA, BONIFATI V. (2011). Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability.. NEUROGENETICS. pp.:33-39
MANGANELLI F, PISCIOTTA C, DUBBIOSO R, IODICE R, CRISCUOLO C, RUGGIERO L, DE MICHELE G, SANTORO L. (2011). Electrophysiological characterisation in hereditary spastic paraplegia type 5.. CLINICAL NEUROPHYSIOLOGY. pp.:819-822
PISCIOTTA C, MANGANELLI F, DUBBIOSO R, RUGGIERO L, IODICE R, SANTORO L. (2011). Thermosensitive hereditary neuropathy with liability to pressure palsy.. MUSCLE & NERVE. pp.:448-449
CARSANA A, FRISSO G, INTRIERI M, TREMOLATERRA MR, SAVARESE G, SCAPAGNINI G, ESPOSITO G, SANTORO L, SALVATORE F (2010). A 15-year molecular analysis of DMD/BMD: genetic features in a large cohort. FRONTIERS IN BIOSCIENCE. pp. 12:547-558
LAMPERTI C, FABBRI G, VERCELLI L, D'AMICO R, FRUSCIANTE R, BONIFAZI E, FIORILLO C, BORSATO C, CAO M, SERVIDA M, GRECO F, DI LEO R, VOLPI L, MANZOLI C, CUDIA P, PASTORELLO E, RICCIARDI L, SICILIANO G, GALLUZZI G, RODOLICO C, SANTORO L, TOMELLERI G, ANGELINI C, RICCI E, PALMUCCI L, MOGGIO M, TUPLER R. (2010). A standardized clinical evaluation of patients affected by facioscapulohumeral muscular dystrophy: The FSHD clinical score. . MUSCLE & NERVE. pp. 5:213-217
ESTRANEO A, MORETTA P, LORETO V, LANZILLO B, SANTORO L, TROJANO L. (2010). Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. . NEUROLOGY. pp. 7:239-245
NOLANO M, DONADIO V, PROVITERA V, SANTORO L. (2010). Possible contribution of vascular innervation to somatic sensory function. . PAIN. pp. 2:552-553
NOLANO M, PROVITERA V, CAPORASO G, STANCANELLI A, VITALE DF, SANTORO L. (2010). Quantification of pilomotor nerves: a new tool to evaluate autonomic involvement in diabetes.. NEUROLOGY. pp. 9:1089-1097
CARSANA A., FRISSO G., INTRIERI M., TREMOLATERRA M.R., SAVARESE G., SCAPAGNINI G., ESPOSITO G., SANTORO L., SALVATORE F (2010). A 15-year molecular analysis of Duchenne/Becker muscular dystrophy: genetic features in a large cohort. FRONTIERS IN BIOSCIENCE. pp. 12:547-558
PROVITERA V, NOLANO M, CAPORASO G, STANCANELLI A, SANTORO L, KENNEDY WR. (2010). Evaluation of sudomotor function in diabetes using the dynamic sweat test.. NEUROLOGY. pp. 7:50-56
NOLANO M, PROVITERA V, SANTORO L. (2010). Internodal length variability of dermal myelinated fibres.. BRAIN. pp. 2:1-2
SANTORO L, NOLANO M, FARASO S, FIORILLO C, VITIELLO C, PROVITERA V, AURINO S, NIGRO V. (2010). Perioral skin biopsy to study skeletal muscle protein expression.. MUSCLE & NERVE. pp. 7:392-398
PISCIOTTA C, MANGANELLI F, IODICE R, BELLONE E, GEROLDI A, VOLPI N, MANDICH P, SANTORO L. (2009). Two families with novel PMP22 point mutations: genotype-phenotype correlation.. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. pp. 5:208-212
MANGANELLI F, VITALE C, SANTANGELO G, PISCIOTTA C, IODICE R, COZZOLINO A, DUBBIOSO R, PICILLO M, BARONE P, SANTORO L. (2009). Functional involvement of central cholinergic circuits and visual hallucinations in Parkinson's disease. BRAIN. pp. 6:2350-2355
PADUA L, BRIANI C, JANN S, NOBILE-ORAZIO E, PAZZAGLIA C, MORINI A, MONDELLI M, CIARAMITARO P, CAVALETTI G, COCITO D, FAZIO R, SANTORO L, GALEOTTI F, CARPO M, PLASMATI R, BENEDETTI L, SCHENONE A, MARCHETTINI P, CRUCCU G. (2009). Validation of the Italian version of the Neuropathic Pain Symptom Inventory in peripheral nervous system diseases. NEUROLOGICAL SCIENCES. pp. 8:99-106
MARTINO D, MACEROLLO A, ABBRUZZESE G, BENTIVOGLIO AR, BERARDELLI A, ESPOSITO M, FABBRINI G, GIRLANDA P, GUIDUBALDI A, LIGUORI R, LIUZZI D, MARINELLI L, MORGANTE F, SABETTA A, SANTORO L, DEFAZIO G. (2009). Lower limb involvement in adult-onset primary dystonia: frequency and clinical features. EUROPEAN JOURNAL OF NEUROLOGY. pp. 5:1-5
MANGANELLI F, PISCIOTTA C, IODICE R, CALANDRO S, DUBBIOSO R, RANIERI A, SANTORO L. (2009). Case of acute motor conduction block neuropathy (AMCBN).. MUSCLE & NERVE. pp.:224-226
SOLARI A, LAUR" M, SALSANO E, RADICE D, PAREYSON D; ON BEHALF OF THE CMT-TRIAAL STUDY GROUP (2008). Reliability of clinical outcome measures in Charcot-Marie-Tooth disease. . NEUROMUSCULAR DISORDERS. pp. 7:19-26
Project Title:
Morphologic and morphometric evaluation of skin innervation in Charcot-Marie-Tooth Syndrome.
More than 40 genes have been identified as causative of different CMT phenotype. The majority of patients have mutations in genes whose products are structural protein of compact or non-compact myelin (PMP22, MPZ, Cx32), but several patients have much more rare mutations of proteins with a wide range of function. For these reasons addressing the molecular diagnosis can be challenging and the analysis of morphological aspects of myelinated fibers in the glabrous skin and of unmyelinated fibers in the hairy skin can be very useful to guide the molecular test. Moreover, from nervous tissue in the skin it is possible to extract the cDNA and therefore, to quantify the product of the involved genes.