Ikerbasque Visiting Professor. Unidad de Biofisica. University of the Basque Country. Bilbao, Spain (2013-...)
Dean of the Faculty of Health Science, University of Molise, Campobasso (2005-2012)
Professor of Pharmacology, Faculty of Health Science, University of Molise (2004-…)
Associate Professor of Pharmacology at the Department of Neuroscience of the University of Naples Federico II, Faculty of Medicine (1998-2004)
Assistant Professor of Pharmacology at the Department of Neuroscience of the University of Naples Federico II, Faculty of Medicine. (1995-1998)

Research Assistant Professor at the Department of Molecular Physiology and Biophysics of Baylor College of Medicine, Houston, TX, USA (1994-1995)
Research Assistant at the Department of Molecular Physiology and Biophysics of Baylor College of Medicine, Houston, TX, USA (1990-1993)
PhD in Cellular and Molecular Biology and Pathology. Dept. of Cellular and Molecular Biology and Pathology. Thesis on : “Voltage-dependent K+ channels : a molecular pharmacology approach to the identification of the pore region” (1992)
Medical Degrees (110/110 cum laude). Institute of Pharmacology, University of Naples Federico II). Thesis in Pharmacology: “Role of calcium in the in vitro release of dopamine from tuberoinfundibilar hypothalamic neurons : pharmacological modulation” (1985)
High School diploma (60/60) (1979)

The main research themes are focused on the functional, pathophysiological, and pharmacological role(s) of diverse classes of ionic channels and transporters. Throughout the years, these themes have been pursued by means of an integrated approach using electrophysiological, biochemical, genetic, and in-silico modelling, and pharmacological techniques.
In particular, the following research themes have been addressed:
Characterization of the biophysical and pharmacological properties, as well as of the structure-function relationships, of specific classes of ion channels in native and heterologous expression systems
Mutational analysis, functional expression, functional properties, and genotype-phenotype correlations of ion channels and transporters involved in the following human diseases: Long QT syndrome (KV11.1); Benign Familial Neonatal Seizures (KV7.2, KV7.3); Hyperekplexia (GLYRA1); Cancer (KV11.1, NaV1.7); Neurodegenerative diseases (KV3.3, KV3.4, Kv7.x); Velocardiofacial syndrome (SCL7A4); Protein intolerance with lysinuria(SCL7A7); Familial Hemiplegic Migraine of Infancy (FHM-2; ATP1A2)
Identification of the pharmacological properties of ion channels involved in therapeutic and/or toxic actions of drugs in humans (KV11.1; KV7.2-7.3; NaV1.2 and NaV1.5; TRPM8..
Role of Kv7 channels in neuronal, cardiovascular, skeletal muscle, gastrointestinal function
Modulation of ionchannels by reactiveoxygen and nitrogenspecies
Characterization of the pharmacological properties of ion channels and transporters involved in the regulation of neurotransmitter release at presynaptic terminals

1. SOLDOVIERI MV, MICELI F, TAGLIALATELA M (2011). Driving with no
brakes: molecular pathophysiology of kv7 potassium channels .
PHYSIOLOGY, vol. 26, p. 365-376, ISSN: 1548-9213 (17 citazioni)
2. Iannotti FA, Panza E, Barrese V, Viggiano D, Soldovieri MV,
Taglialatela M (2010). Expression, Localization, and Pharmacological
Role of K(v)7 Potassium Channels in Skeletal Muscle Proliferation,
Differentiation, and Survival after Myotoxic Insults. JOURNAL OF
PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 332, p. 811-820,
ISSN: 0022-3565, doi: 10.1124/jpet.109.162800 (13 citazioni)
3. Luisi R, Panza E, Barrese V, Iannotti FA, Viggiano D, Secondo A,
Canzoniero LMT, Martire M, Annunziato L, Taglialatela M (2009).
Activation of pre-synaptic M-type K+ channels inhibits
[H-3]d-aspartate release by reducing Ca2+ entry through P/Q-type
voltage-gated Ca(2+)channels. JOURNAL OF NEUROCHEMISTRY, vol. 109, p.
168-181, ISSN: 0022-3042, doi: 10.1111/j.1471-4159.2009.05945.x (15
citazioni)
4. Miceli F, Soldovieri MV, Lugli L, Bellini G, Ambrosino P, Migliore
M, del Giudice EM, Ferrari F, Pascotto A, Taglialatela M (2009).
Neutralization of a unique, negatively-charged residue in the voltage
sensor of K(V)7.2 subunits in a sporadic case of benign familial
neonatal seizures. NEUROBIOLOGY OF DISEASE, vol. 34, p. 501-510, ISSN:
0969-9961, doi: 10.1016/j.nbd.2009.03.009 (14 citazioni)
5. Miceli F, Soldovieri MV, Martire M, Taglialatela M (2008).
Molecular pharmacology and therapeutic potential of neuronal
Kv7-modulating drugs. CURRENT OPINION IN PHARMACOLOGY, vol. 8, p.
65-74, ISSN: 1471-4892, doi: 10.1016/j.coph.2007.10.003 (59 citazioni)

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