Sabina Pappatà
Sabina Pappatà
affiliation: CNR - Istituto di neuroscienze
research area(s): Neuroscience
  • Genetics and Molecular Medicine
  • Neurosciences
  • Molecular Pathology and Pathophysiology
University/Istitution: Università di Napoli Federico II
Sabina Pappatà
Born August 10th 1956 in Rome (Italy)

Corrent position: Senior Scientist at the Institute of Biostructure
and Bioimaging (IBB), Consiglio Nazionale delle Ricerche (CNR)
Via De Amicis, 95, 80145 - Naples - ITALY
Phone +39 081 2203187 ext -216
FAX +39 081 2296117
MP +39 335 8014693

Profile - Educational and Scientific Profile

2007- present: Senior Researcher at IBB-CNR, Naples,Italy
January 2006- present: Consultant radiologist and nuclear medicine, University Hospital "Federico II" of Naples (Dir. Prof. M. Salvatore)
2001-2007: Researcher at IBB-CNR, Naples, Italy
1990-2001: Researcher (CR1) at the INSERM (French National Institute of Health and Medical Research) 334 Unit and Cognitive Neuroimaging Unit , at the Service Hospitalier Frédéric Joliot (SHFJ), Commissariat à l’Energie Atomique (CEA), Orsay, France.
1984-1989: Research Fellow at the SHFJ-CEA, Orsay, France.
1988: Specialization in Diagnostic Radiology, Medical School University “La Sapienza” of Rome, Thesis, Honours.
1982-1984 Fellow, Department of Neuroradiology and of Nuclear Medicine, University of Rome.
1982: M.D. Degree, Medical School University of Rome “La Sapienza” of Rome , Doctoral thesis, Honours
1980-1981 Training at the Department of Neurology, S. Filippo Hospital, Rome.

Invited speaker at several international and national meeting (functional neuroimaging and neurochemical imaging, methods and application in neurodegenerative disorders and cerebral ischemia).
Teaching activity: Masters, Biotechnological Science Degree Course, Faculty of Medicine “Federico II” Degree Course, Education in Nuclear Neurology.
Reviewer activity for Stroke, J Cereb Blood Flow Metab, J Neurology Neurosurg and Psychiatry, Human Brain Mapping, Neurology, J Neuoscience Methods, European Journal of Nuclear Medicine and Molecular Imaging, Annals of Neurology, PlosOne. Reviewer of grants (MIUR, Wellcome Trust, Academy of Finland). Examiner and director of PhD thesis in Cognitive Neuroscience and Neuroscience Paris VI University, Ecole doctorale du medicament Paris V, France.
Field of research activity: development and/or application of MRI and functional/neurochemical PET/SPECT imaging methods for the study of normal human brain function and pathophysiology of cerebrovascular and neurodegenerative disorders.
In particular Dr Sabina Pappatà has contributed to the first in vivo quantification with PET of benzodiazepine receptors (central type) in normal human brain (J Cereb Blood Flow Metab.1988 8:304-13) and more recently to the characterization of changes in these receptors in MCI and Alzheimer’s Disease with SPET/PET (Eur J Nucl Med Mol Imaging. 2010 37:1156-63, Brain 2012 135:2817-25). She has provided the first in vivo imaging of cerebral distribution of Acetylcholinestarese in normal human brain using PET and 11C-Physostigmine (J Neurochem. 1996 67:876-9). She has also participated to the development of new PET/11C-raclopride methods for the in vivo detection of endogenous dopamine release during cognitive activations (reward and learning) in normal volunteers (Neuroimage. 2002 16:1015-27). Another important line of research has been the in vivo imaging with PET of neuroinflammation. In a pioneering PET study it has been shown that 11C-PK11195 binding, a radioligand of Translocator Protein 18 kDa (TSPO), is increased in areas remote from the focal infarct lesion as a result of microglia activation in regions site of ongoing degeneration (Neurology. 2000 55:1052-1054). Moreover new MRI methods such as DWI/DTI have been applied to the study of patients with cerebrovascular and neurodegenerative disorders and PET-FDG/SPECT-Dopamine transporters (DAT) studies have been performed to characterize metabolic/nigrostriatal dopaminergic alterations in patients with Parkinson Disease.

Current research activities include:

- PET-FDG and SPECT-123I-Ioflupane studies in patients with de NOVO parkinsonism. The main aim of this project is the identification of “early” patterns of metabolic/dopaminergic alterations in patients with cognitive disturbances and/or at risk of dementia.

- Study of micro-structural alterations of brain tissues in neurodegenerative diseases with MRI-DWI

- In vivo imaging and characterization of new radiotracer (18F-DPA714) for TSPO sites in normal mouse brain and peripheral tissues using small-animal PET. TSPO is actually considered a potential marker of microglia activation and neuroinflammation and 18F-DPA714 is a good candidate for imaging having more favourable characteristics than 11C-PK11195.

- In vivo imaging of microglia activation with microPET and 18F-DPA714 in experimental models of neuroinflammation (Stroke, Multiple Sclerosis (EAE) and Amyotrophic Lateral Sclerosis (ALS). This project is supported by the EU 7th Framework Programme under grant agreement n° 278850 (INMIND: Imaging of Neuroinflammation in Neurodegenerative Diseases) and it is performed in collaboration with the Dept of Neuroscience of the University Federico II of Naples (Prof L. Annunziato) and CEINGE Biotecnologie Avanzate.
Pascual B, Prieto E, Arbizu J, Marti-Climent JM, Peñuelas I, Quincoces
G, Zarauza R, Pappatà S, Masdeu JC. Decreased carbon-11-flumazenil
binding in early Alzheimer's disease. Brain. 2012 Sep;135(Pt
0 Citazioni

Jacobs AH, Tavitian B; INMiND consortium. Noninvasive molecular
imaging of neuroinflammation. J Cereb Blood Flow Metab. 2012
5 Citazioni
Pappatà S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick
K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A,
De Michele G, Salvatore M, Barone P. Mild cognitive impairment in
drug-naive patients with PD is associated with cerebral
hypometabolism. Neurology. 2011Oct 4;77(14):1357-1362.
17 Citazioni
Pappatà S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V,
Iavarone A, Comerci M, Loré E, Panico MR, Quarantelli M, Postiglione
A, Salvatore M. SPECT imaging of GABA(A)/benzodiazepine receptors and
cerebral perfusion in mild cognitive impairment. Eur J Nucl Med Mol
Imaging. 37(6):1156-63, 2010.
5 Citazioni

Pellecchia MT, Barone P, Mollica C, Salvatore E, Ianniciello M, Longo
K, Varrone A, Vicidomini C, Picillo M, De Michele G, Filla A,
Salvatore M and Pappatà S. Diffusion-weighted imaging in multiple
system atrophy: A comparison between clinical subtypes. Mov Disord.
2009 24(5):689-96.
14 Citazioni
Project Title:
PET-FDG and SPECT-123-Ioflupane studies in patients with de NOVO parkinsonism

Project Title:
In vivo imaging of microglia activation with microPET and 18F-DPA714 in experimental models of neuroinflammation