Antonella Lisa
Antonella Lisa
e-mail:
affiliation: Istituto di Genetica Molecolare-CNR, Pavia
research area(s): Computational Biology, Genetics And Genomics
Course: Genetics, Molecular and Cellular Biology
University/Istitution: Università di Pavia
QUALIFICATIONS
1986: Graduation in Biological Sciences, University of Pavia, Italy.
1988-1993: Fellowships at the Institute of Molecular Genetics (IGM) - CNR in Pavia
1994-2000: Researcher with fixed-term contract at IGM - CNR in Pavia
2001 - : Technologist at the Institute of Molecular Genetics IGM - CNR in Pavia
1991 - : System manger of the computer network at IGM-CNR
2003 - : Web Master at IGM-CNR
2002-2009: Member of the IGM-CNR Committee
2007 - : Chief of the group CNR: ME.P07.005.001 "Genetics of the Italian population and mechanisms of evolution"
2011 - : System Manager of the High Performance Computer in Cluster configuration of the CABgen laboratory at IGM-CNR


TEACHING ACTIVITY
Teaching was held at the University of Pavia. In 2003 she received recognition as expert on the subject "Genetics" for the Master in Biological Sciences; from 2008 to today she has held the course "Biostatistics" for the PhD School in Genetics and Biomolecualr Sciences; from 2009 to 2012 she was the holder of a module (3 credits) of the course "Bioinformatics" in the Laurea Magistralis "Molecular Biology and Genetics". She has also organized many laboratories in Statistics and Bioinformatics for masters in Applied Genetics and Biological Sciences.
- Analysis of the genetic structure of Italian population through the study of surnames considered as patrilineally transmitted genetic markers. The genetic heterogeneity of different areas from the geographic, linguistic or historical point of view has been analyzed and the amount and direction of recent and past human migration has been estimated.
- Implementation of a new sampling methodology, based on surname distributions, to obtain sample of individuals autochthonous of Italian provinces. The DNA analysis of this sample could better reveal the genetic profile of the Italian population.
- Study of consanguinity in Italy, through the analysis of the variation, in space and time, of the frequency of consanguineous marriages, to estimate "inbreeding" coefficient of local populations. The spatial heterogeneity of inbreeding in Sardinia between 1850 and 1970 is also analyzed to verify if there are areas of overlap between "reproductive longevity" and high levels of consanguinity.
- Application of multivariate statistical analysis for the genetic study of complex diseases
- Study of factors influencing the evolution in human populations.
- Development of software and database for the analysis of molecular data.
• Silini E., Locasciulli A., Santoleri L., Gargantini L., Pinzello G., Montillo M., Foti L., Lisa A., Orfeo N., Magliano E., Nosari A., Morra E. (2002) Hepatitis C virus infection in a hematology ward: evidence for nosocomial transmission and impact on hematologic disease outcome. Haematologica, 87(11):1200-8.
• Romano V., Cali' F., Ragalmuto A., D'Anna R.P., Flugy A., De Leo G., Giambalvo O., Lisa A., Fiorani O., Di Gaetano C., Salerno A., Tamouza R., Charron D., Zei G., Matullo G., Piazza A. (2003) Autosomal microsatellite and mtDNA genetic analysis in Sicily (Italy). Annals of Human Genetics. 67, 1-12.
• Zei G., Lisa A., Fiorani O., Magri C., Quintana-Murci L., Semino O., Santachiara Benerecetti A.S. (2003) From surnames to history of Y-chromosomes: the Sardinian population as a paradigm. European Journal of Human Genetics, 11, 802-807.
• Silini E., Belli L., Brambilla S., Foti L., Gritti C., Lisa A., Alberti A.B., Vinci M., De Carlis L., Rondinara G., Pinzello G. (2003) Sequence variation in the hypervariable Region 1 of hepatitis C virus and posttransplantation recurrent hepatitis. Liver Transplantation, 9(10), 1040-1047.
• Rebuzzini P., Lisa A., Giulotto E., Mondello C. (2004) Chromosomal end-to-end fusions in immortalized mouse embryo fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit. Cancer Letters. 203: 79-86.
• Zei G., Lisa A., Fiorani O., Moroni G.A., Cavalli-Sforza L.L. (2005) Spatial and temporal variation of consanguinity in Italy. Human Evolution, 20:201-215.
• Turci M., Pilotti E., Ronzi P., Magnani G., Boschini A. Parisi S.G., Zipeto D., Lisa A., Casoli C., Bertazzoni U. (2006) Coinfection With HIV-1 and Human T-Cell Lymphotropic Virus Type II in Intravenous Drug Users Is Associated With Delayed Progression to AIDS. Journal of Acquired Immune Deficiency Syndromes, 41(1):100-106.
• Pollicino T., Raffa G., Costantino L., Lisa A., Campello C., Squadrito G., Levrero M., Raimondo G. (2007) Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma. Hepatology. 45(2): 277-285.
• Lisa A., De Silvestri A., Mascaretti L., Degiuli A., Guglielmino C.R. (2007) HLA genes and surnames show a similar genetic structure of Lombardy: does it reflect the history of the region? American Journal of Human Biology. 19(3): 311-318.
• Astolfi P., Caselli G., Fiorani O., Lipsi R., Lisa A., Tentoni S. (2009) Late reproduction behaviour in Sardinia: Spatial analysis suggests local attitude towards reproductive longevity. Evolution and Human Behaviour. 30(2): 93-102.
• Passadore I., Iadarola P., Di Poto C., Giuliano S, Montecucco C., Cavagna L., Bonino C., Meloni F., Fietta A.M., Lisa A., Salvini R., Bardoni A.M. (2009) 2-DE and LC-MS/MS for a comparative proteomic analysis of BALf from subjects with different subsets of inflammatory myopathies. Submitted to Journal of Proteome Research. 8(5): 2331-2340.
• Lisa A., Monti D., Franceschi C., Scovassi A.I. (2009) Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis. Gerontology. 55:427-429.
• Moratto D., Giliani S., Bonfim C., Mazzolari E., Fischer A., Ochs H.D., Cant A.J., Thrasher A.J., Cowan M.J., Albert M.H., Small T., Pai S-Y., Haddad E., Lisa A., Hambleton S., Slatter M., Cavazzana-Calvo M., Malahoui N., Picard C., Torgerson T.R., Burroughs L., Koliski A., Neto J.Z., Porta F., Qasim W., Veys P., Kavanau K., Ho"nig M., Schulz A., Friederich W., Notarangelo L.D. (2011) Long-term outcome and lineage-specific chimerism in 187 patients with Wiskott- Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980- 2008. An international collaborative study. Blood. 18(6):1675-1684.
• Tentoni S, Lisa A, Fiorani O, Lipsi RM, Caselli G, Astolfi P. (2012) Spatial analysis of historical and recent data sheds light on woman reproductive longevity in Sardinia. Journal of Biosocial Science. 44(3): 257-272.
• Leva V, Giuliano S, Bardoni A, Camerini S, Crescenzi M, Lisa A, Biamonti G, Montecucco A. (2012) Phosphorylation of SRSF1 is modulated by replicational stress. Nucleic Acids Research. 40(3):1106-17.
• Cheng YC, Anderson CD, Bione S, et al. (2012) Are Myocardial Infarction-Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke? Stroke. 43(4):980-986.
• Rootsi S, Myres NM, Lin AA, et al. (2012) Distinguishing co-ancestries of European and Caucasian human Y-chromosomes within haplogroup G. European Journal of Human Genetics. doi: 10.1038/ejhg.2012.86
• Lanni C. et al. 2012. Influence of COMT Val158met polymorphism on Alzheimer’s disease and mild cognitive impairment in Italian patients. Journal of Alzheimer's Disease. In press.


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