Roberto Colombo
Roberto Colombo
e-mail:
affiliation: Università di Milano
research area(s): Cell Biology, Chemical Biology
Course: Biomolecular Sciences
University/Istitution: Università di Milano
After the Speciality Degree (Biological Research,1973), he was Assistant Professor to Human Anatomy Chair (Milano University) firstly and then to Embryology and Experimental Morphology Chair of the same University. On 1979, he was in England as Visiting Fellow at the Warwick University, Developmental Biology Lab, directed by Hugh Woodland (the pupil of the great embryologist J.B.Gurdon). On the 1983, he became Associated Professor of Histology & Embryology (Milan University). On the 1987, he organized in Monza (Italy) the Second World Meeting on ACTIN (the first one have been organized in Sydney, on the 1982, by Cris Dos Remedios) which was attended by all the leader researchers in the field. Starting from 1993 he works at the University of Milano (Italy) as Full Professor of Cytology & Histology.
His experimental activity, firstly addressed to Embryology researches, gradually changed, then focusing on the Cytoskeleton in the whole and, in particular, on the cytoskeletal actin component. The initial approach, mainly immunocytochemical, easier changed, becoming more biochemical and structural, considering objects like the actin aggregational state, the actin filament structure and the 3D cell actin formations (actin networks, bundles and the spatial orientation of microfilaments). His papers, on the oxidative stress and the actin cytoskeleton, have provoked a great interest, obtaining a large number of citations. Up till now, he has been invited to many International Meetings as a Chairman or as an Invited Speaker.
- DALLE DONNE I., COLOMBO G., GAGLIANO N., COLOMBO R., GIUSTARINI D., ROSSI R. and MILZANI A.(2011)
S-Glutathionylation in life and death decision of the cell.
Free Rad.Res. , 45(1), pp. 3-15

- ELLI L., RONCORONI L., DONEDA L., CIULLA M.M., COLOMBO R., BRAIDOTTI P. BONURA A. and BARDELLA M.T. (2011)
Imaging analysis of the gliadin direct effect on tight junctions in an in vitro three-dimensional Lovo cell line culture system.
Toxicol.in Vitro 25, 45-50

- DALLE DONNE I., CARINI M., VISTOLI G., GAMBERONI L., GIUSTARINI D., COLOMBO R., MAFFEI FACINO R., ROSSI R., MILZANI A. and ALDINI G. (2007)
Actin Cys-374 as a nucleophilic target of alpha,beta-unsatured aldehydes.
Free Radic.Biol.Med. 42(5):583-98.

- DALLE DONNE I., GIUSTARINI D., ROSSI R., COLOMBO R. and MILZANI A. (2003)
Reversible S-Glutathionylation of Cys-374 regulates actin filament formation by inducing structural changes in the actin molecule.
Free Rad.Biol.Med. 34(1), 23-32

- DALLE DONNE I., ROSSI R., GIUSTARINI D., GAGLIANO N., DI SIMPLICIO P., COLOMBO R. and MILZANI A. (2002)
Methionine oxidation as a major cause of the functional impairment of oxidized actin.
Free Rad.Biol.Med. 32(9), 927-937
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