Giulia Soldà
e-mail: giulia.solda AT unimi.it
affiliation: Università di Milano
research area(s): Genetics And Genomics, Molecular Biology
Course:
Biomolecular Sciences
University/Istitution: Università di Milano
University/Istitution: Università di Milano
ACADEMIC APPOINTMENTS
From December 2008: "RICERCATORE UNIVERSITARIO" in APPLIED BIOLOGY (corresponding to an ASSISTANT PROFESSOR position) at the Department of Biology and Genetics for Medical Sciences, Medical Faculty, University of Milan.
EDUCATION
2005-2007: Two-year fellowship for "Post-doctoral Research Training Overseas" from the University of Milan, to perform research on "Evolution and role of noncoding RNAs in mammalian development and disease" at the Institute for Molecular Bioscience, University of Queensland, Brisbane (Australia).
2005: PhD degree in MOLECULAR AND CELLULAR BIOLOGY, University of Milan.
2001: Master degree (Laurea) in MEDICAL BIOTECHNOLOGY (110/110 cum laude), University of Milan.
DOCTORAL AND POST-DOCTORAL TRAINING
2009: 25° Lipari International Summer School on BioInformatics and Computational Biology, focusing on "RNAs : structure, function and therapy", Lipari (ME), Italia.
2008: EMBO Practical Course on High-throughput microRNA profiling, EMBL, Heidelberg, Germany.
2007: Winter School in Mathematical and Computational Biology, Queensland Bioscience Precinct, Brisbane, QLD, Australia.
2004: Short course on "Molecular Evolution and Comparative Genomics", Dept of Biomolecular Sciences and Biotechnology, University of Milan, Italy.
From December 2008: "RICERCATORE UNIVERSITARIO" in APPLIED BIOLOGY (corresponding to an ASSISTANT PROFESSOR position) at the Department of Biology and Genetics for Medical Sciences, Medical Faculty, University of Milan.
EDUCATION
2005-2007: Two-year fellowship for "Post-doctoral Research Training Overseas" from the University of Milan, to perform research on "Evolution and role of noncoding RNAs in mammalian development and disease" at the Institute for Molecular Bioscience, University of Queensland, Brisbane (Australia).
2005: PhD degree in MOLECULAR AND CELLULAR BIOLOGY, University of Milan.
2001: Master degree (Laurea) in MEDICAL BIOTECHNOLOGY (110/110 cum laude), University of Milan.
DOCTORAL AND POST-DOCTORAL TRAINING
2009: 25° Lipari International Summer School on BioInformatics and Computational Biology, focusing on "RNAs : structure, function and therapy", Lipari (ME), Italia.
2008: EMBO Practical Course on High-throughput microRNA profiling, EMBL, Heidelberg, Germany.
2007: Winter School in Mathematical and Computational Biology, Queensland Bioscience Precinct, Brisbane, QLD, Australia.
2004: Short course on "Molecular Evolution and Comparative Genomics", Dept of Biomolecular Sciences and Biotechnology, University of Milan, Italy.
My main research interests concern:
1) mechanisms of gene expression regulation at the post-transcription level (with a particular focus on microRNAs and NMD);
2) role of noncoding RNAs in mammalian development as well as in the pathogenesis of human complex diseases.
3) study of the molecular bases and pathogenic mechanisms underlying some human genetic diseases (in particular non-syndromic sensorineural hearing loss, Multiple sclerosis, Parkinson disease, and rare inherited coagulation disorders)
More recently, I've been interested in next-generation sequencing technologies and have been involved mainly in transcriptome (RNA-seq) data analysis and exome sequencing.
1) mechanisms of gene expression regulation at the post-transcription level (with a particular focus on microRNAs and NMD);
2) role of noncoding RNAs in mammalian development as well as in the pathogenesis of human complex diseases.
3) study of the molecular bases and pathogenic mechanisms underlying some human genetic diseases (in particular non-syndromic sensorineural hearing loss, Multiple sclerosis, Parkinson disease, and rare inherited coagulation disorders)
More recently, I've been interested in next-generation sequencing technologies and have been involved mainly in transcriptome (RNA-seq) data analysis and exome sequencing.
SELECTED PUBLICATIONS (LAST 5 YEARS)
1. Mercer T.*, Wilhelm D.*, Dinger M.*, Soldà G.*, Korbie D., Glazov E., Truong V., Schwenke M., Simons C., Matthaei K., Saint R., Koopman P., Mattick J. (2011) Expression of distinct RNAs from 3' untranslated regions. Nucleic Acids Research, 39:2393-403. *equal contribution.
2. Asselta R., Rimoldi V., Guella I., Soldà G., De Cristofaro R., Peyvandi F., Duga S. (2010) Response: Further thoughts on the "phantom" delta6/7 FXI isoform. Blood 116:1186-1187.
3. Asselta R., Rimoldi V., Guella I., Soldà G., De Cristofaro R., Peyvandi F., Duga S. (2010) Molecular characterization of in-frame and out-of-frame alternative splicings in coagulation factor XI pre-mRNA. Blood 115:2065-2072.
4. Soldà G., Oldoni F., Asselta R., Primignani P., Castorina P., Radaelli C., Coviello D., Duga S. (2010) Role of the microRNA-183 family in the pathogenesis of hereditary nonsyndromic hearing loss in the Italian population. European Journal of Human Genetics 18(Supplement 1):328.
5. Soldà G., Makunin I.V., Sezerman O.U., Corradin A., Corti G., Guffanti A. (2009) An Ariadne's thread to the identification and annotation of noncoding RNAs in eukaryotes. Briefings in Bioinformatics 10:475-489.
6. Guffanti A., Iacono M., Pelucchi P., Kim N., Soldà G., Croft L.J., Taft R.J., Rizzi E., Askarian-Amiri M., Bonnal R.J., Callari M., Mignone F., Pesole G., Bertalot G., Rossi Bernardi L., Albertini A., Lee C., Mattick J.S., Zucchi I., de Bellis G. (2009) A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genomics 10:163.
7. Dinger M.E., Amaral P.P., Mercer T.R., Pang K.C., Bruce S.J., Gardiner B.B., Askarian-Amiri M.E., Ru K., Soldà G., Simons C., Sunkin S.M., Crowe M.L., Grimmond S.M., Perkins A.C., Mattick J.S. (2008) Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research 18: 1433-1445.
8. Soldà G.*, Suyama M.*, Pelucchi P., Guffanti A., Boi S., Rizzi E., Bork P., Tenchini M.L., Ciccarelli F.D. (2008) Non-random retention of protein-coding overlapping genes in Metazoa. BMC Genomics 9: 174. *equal contribution.
1. Mercer T.*, Wilhelm D.*, Dinger M.*, Soldà G.*, Korbie D., Glazov E., Truong V., Schwenke M., Simons C., Matthaei K., Saint R., Koopman P., Mattick J. (2011) Expression of distinct RNAs from 3' untranslated regions. Nucleic Acids Research, 39:2393-403. *equal contribution.
2. Asselta R., Rimoldi V., Guella I., Soldà G., De Cristofaro R., Peyvandi F., Duga S. (2010) Response: Further thoughts on the "phantom" delta6/7 FXI isoform. Blood 116:1186-1187.
3. Asselta R., Rimoldi V., Guella I., Soldà G., De Cristofaro R., Peyvandi F., Duga S. (2010) Molecular characterization of in-frame and out-of-frame alternative splicings in coagulation factor XI pre-mRNA. Blood 115:2065-2072.
4. Soldà G., Oldoni F., Asselta R., Primignani P., Castorina P., Radaelli C., Coviello D., Duga S. (2010) Role of the microRNA-183 family in the pathogenesis of hereditary nonsyndromic hearing loss in the Italian population. European Journal of Human Genetics 18(Supplement 1):328.
5. Soldà G., Makunin I.V., Sezerman O.U., Corradin A., Corti G., Guffanti A. (2009) An Ariadne's thread to the identification and annotation of noncoding RNAs in eukaryotes. Briefings in Bioinformatics 10:475-489.
6. Guffanti A., Iacono M., Pelucchi P., Kim N., Soldà G., Croft L.J., Taft R.J., Rizzi E., Askarian-Amiri M., Bonnal R.J., Callari M., Mignone F., Pesole G., Bertalot G., Rossi Bernardi L., Albertini A., Lee C., Mattick J.S., Zucchi I., de Bellis G. (2009) A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genomics 10:163.
7. Dinger M.E., Amaral P.P., Mercer T.R., Pang K.C., Bruce S.J., Gardiner B.B., Askarian-Amiri M.E., Ru K., Soldà G., Simons C., Sunkin S.M., Crowe M.L., Grimmond S.M., Perkins A.C., Mattick J.S. (2008) Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research 18: 1433-1445.
8. Soldà G.*, Suyama M.*, Pelucchi P., Guffanti A., Boi S., Rizzi E., Bork P., Tenchini M.L., Ciccarelli F.D. (2008) Non-random retention of protein-coding overlapping genes in Metazoa. BMC Genomics 9: 174. *equal contribution.
No projects are available to students for the current accademic year.