Giuseppina Caretti
Giuseppina Caretti
affiliation: Università di Milano
research area(s): Developmental Biology, Genetics And Genomics
Course: Biomolecular Sciences
University/Istitution: Università di Milano
Academic Record
1999-2003. PhD in Biotechnology and Molecular Medicine, University of Modena (I).
1991-1996. Degree in Biological Sciences, Università degli Studi di Milano (I).
1986-1991. High School Liceo Scientifico A. Calini, in Brescia (I).

Research Record
2008-present. Non-tenured Assistant Professor in the Department of Biomolecular Sciences and Biotechnology, University of Milan Working on the role of the histonemethylase SMYD3 in myogenesis
2003-2007. Visiting fellow in the Laboratory of Muscle Stem Cells and Gene Regulation (Dr. Vittorio Sartorelli), NIAMS, NIH, Bethesda, USA, studying the role of the histone methylase Ezh2 in muscle differentiation and the role of DEAD-box RNA helicases in promoting myogenesis.
2000-2002. PhD student in the Laboratory of Prof. Roberto Mantovani, University of Modena, studying NF-Y acetylation and its functional role in transcriptional regulation.
1998-1999. Laboratory of Prof. Roberto Mantovani, University of Milan. Interactions between nucleosomes and transcription factor NF-Y and interactions between NF-Y and RF-X on a MHC class II promoter.
1995-1997. Internship for Master Degree in theLaboratory of Prof. Francesco Blasi, DIBIT, Milan. Functional characterization of DNase I hypersensistive sites in the 5' regulating region of urokinase gene.

Telethon Fellowship 1998-1999.
FIRC (Italian Foundation for Cancer Research) 2000-2002.
NIH Visiting Fellowship 2003-2007.

G. Caretti main research focus is the dissection of epigenetic and molecular mechanisms orchestrating myogenesis. In particular, the aim of her research program is to unveil specific contributions of histone methylases and transcription factors to the process of skeletal muscle stem cells specification and differentiation. She is currently working on the histonemethylase SMYD3 and she is investigating its function in skeletal muscle stem cells differentiation. She pursues her studies combining cellular and molecular biological approaches, employing cell culture and primary skeletal muscle stem cells as amenable models.
Verma R., Xu X., Jaiswal M.K., Olsen C., Mears D., Caretti G., Galdzicki Z.
In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components.
Toxicol Appl Pharmacol. 2011 ;253(3):178-87

Caretti G., Palacios D., Sartorelli V., Puri P.L. PhosphorylEZHion. Cell Stem Cell. 2011; 8(3):262-5.

G.Palacios D., Mozzetta C, Consalvi S., Caretti G., Saccone V., Proserpio V., Marquez V.E., Valente S., Mai V, Forcales S.V., Sartorelli V., Puri P.L. TNF/p38 alpha/Polycomb signalling to Pax7 locus in satellite cells links inflammation to muscle regeneration.
Cell Stem Cell. 2010;7(4):455-469

Manni I., Caretti G., Artuso S., Gurtner A., Emiliozzi V., Sacchi A., Mantovani R., Piaggio G. Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity.
Mol Biol Cell. 2008 ;19(12):5203-13

Di Padova M.*, Caretti G.*, Zhao P., Hoffman E.P., Sartorelli V. Myod acetylation influences temporal patterns of skeletal muscle gene expression.
J Biol Chem. 2007 282(52):37650-9 *Authors contributed equally

Jensen E.D., Niu L., Caretti G., Nicol S.M., Teplyuk N., Stein G.S., Sartorelli V., van Wijnen A.J., Fuller-Pace F.V., Westendorf J.J.p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation.
J Cell Biochem. 2007 103(5):1438-1451

Caretti G., Lei E.P., Sartorelli V. The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions.
Cell Cycle. 2007;6(10):1172-6

Caretti G., Schiltz R.L., Dilworth F.J., Di Padova M., Zhao P., Ogryzko V., Fuller-Pace F.V., P. Hoffman E.P., Tapscott S.J. , and V. Sartorelli. The RNA helicases p68/72 and the noncoding RNA SRA Are Coregulators of MyoD and of Muscle Differentiation.
Dev Cell. 2006;11(4):547-60

Bolognese F., Forni C., Caretti G., Frontini M., Minuzzo M., Mantovani R. The Pole3 bidirectional unit is regulated by MYC and E2Fs.
Gene.2006; 366(1):109-16

Zhao P., Caretti G., Mitchell S., McKeehan E.L., Boskey, AL., Pachman LM., Sartorelli V., and EP. Hoffman. Fgfr4 Is Required for Effective Muscle Regeneration in Vivo: Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway.
J. Biol. Chem. 2006; 281(1), 429-438

No projects are available to students for the current accademic year.