Claudio Tiribelli
Claudio Tiribelli
affiliation: CSF - Centro Studi Fegato, AREA Science PArk, Trieste
research area(s): Experimental Medicine, Cell Biology
Course: Molecular Biomedicine
University/Istitution: Università di Trieste
1. Born in Venice, Italy, October 6, 1946
2. Degree in Medicine, University of Padova, Italy, July 1971, Summa cum Laude
3. Post-Doctoral Degree, Gastroenterology, University of Trieste, Italy, July 1975, Summa cum Laude
4. Married with Rita Russo, one son Mario

Teaching & Academic Positions:
1. Assistant Professor of Medicine, Department of Medicine, University of
2. Associate Professor of Medicine, Department of Medicine, University of
Trieste (Gastroenterology)
3. 1989-2008: Professor of Medicine (Biochemistry Applied to Medicine) University of Trieste
4. 2008-: Professor of Gastroenterology, university of Trieste
5. 2001-present: Director of the Liver Research Center of Trieste.

Sabbatical Periods:
1: Visiting Research Scientist, Department of Pharmacology, State University of Groningen, Groningen, The Netherlands
2: 1998-99: Visiting Professor, Department of Chemistry/Life Sciences, Polytechnic University, Brooklyn, NY, USA
3: 1995-2000, Visiting Professor and Faculty Member, Division of Clinical Pharmacology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Editorial and International Activities:
i. Member of the Editorial Board of Journal of Hepatology and Annals of Hepatology
ii. Associate Editor BBC Research Notes
iii. Regular reviewer for several international journals
iv. Referee for the Scientific Committee of Third World Academy of Sciences
v. 1983-1985: Secretary European Association for the Study of the Liver (EASL)
vi. 1986-1990: Corresponding Membership Secretary of the European Association for the Study of the Liver (EASL)
vii. 1986-1990: Member of the Governing Committee of the International Association for the Study of the Liver (IASL)
viii. 1992-2001: Secretary of the Educational Council of the European Association for the Study of the Liver (EASL)
ix. 2000-: Member of the Editorial Academy of the International Journal of Molecular Medicine.
x. 2001- : Member of the International Advisory Committee of Revista Medica de Chile
xi. 2002- : Associate Editor, Annals of Hepatology
xii. 2007-: Associate editor BMC GE

Other Activities
• 1995-2003: President, Board of Trustees, Fondo Studio Fegato
• 1998-: Referee and consultant officer for research grant at the Third World Academy of Science
1. Molecular Basis of Bilirubin-Induced Neurological Damage
2. New Measurement Tools of bilirubin in the newborns
3. In vitro models of fatty liver and associated diseases
4. Interplay among different cells of the liver in development of damage
5. Stem cells in hepatocellular carcinoma: from the gene to a personalized treatment
1. Corona G, De Lorenzo E, Elia C, Simula MP, Avellini C, Baccarani U, Lupo F, Tiribelli C, Colombatti A, Toffoli G. Differential proteomic analysis of hepatocellular carcinoma. Int J Oncol. 2010, 36(1):93-99.
2. Spano D, Russo R, Di Maso V, Rosso N, Terracciano LM, Roncalli M, Tornillo L, Papasso M, Tiribelli C, Iolascon A. Galectin-1 and its involvement in Hepatocellular Carcinoma aggressiveness. Mol Med, 2010, 16(3-4):102-115.
3. Deganuto M. Cesaratto L, Bellarosa C, Calligaris R, Vilotti S, Renzone G, Scaloni A, Gustincich S, Quadrifoglio F, Tiribelli C, and Tell G. A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein. Proteomics, 2010, 10(8):1645-57.
4. Bedogni G, Gastaldelli A, Manco M, De Col A, Agosti F, Tiribelli C, Sartorio A. Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children. Nutrition, Metabolism & Cardiovascular Diseases, 2010, in press
5. Malik SG, Astrid Irwanto K, Ostrow JD and Tiribelli C. Effect of Bilirubin on Cytochrome c Oxidase Activity of Mitochondria from Mouse Brain and Liver. BMC Research Notes 2010, 3:162.
6. Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Rosina F, Borghesio E, Floreani A, Lazzari R, Niro G, Andriulli A, Muratori L, Muratori P, Almasio PL, Andreone P, Margotti M, Brunetto M, Coco B, Alvaro D, Bragazzi MC, Marra F, Pisano A, Rigamonti C, Colombo M, Marzioni M, Benedetti A, Fabris L, Strazzabosco M, Portincasa P, Palmieri VO, Tiribelli C, Croce L, Bruno S, Rossi S, Vinci M, Prisco C, Mattalia A, Toniutto P, Picciotto A, Galli A, Ferrari C, Colombo S, Casella G, Morini L, Caporaso N, Colli A, Spinzi G, Montanari R, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, Seldin MF.. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature Genetics, 2010, 42(8):658-660
7. Mazzone GL, Rigato I and Tiribelli C. Unconjugated bilirubin modulates nitric oxide production via iNOS regulation. BioScience Trends, 2010, 4(5):244-248.
8. Yang Z,. Philips JD,. Doty RT, Giraudi P, Ostrow JD, Tiribelli C, Smith A and Abkowitz JL. Kinetics and specificity of FLVCR export function and its dependence on hemopexin J. Biol. Chem 2010, 285(37):28874-2882.
9. Bedogni G, Kahn HS, Bellentani S and Tiribelli C A simple index of lipid overaccumulation is a good marker of liver steatosis. BMC Gastroenterology 2010, 10:98.,
10. Mediavilla MG, Di Venanzio GA, Guibert EE and Tiribelli C. Heterologous Ferredoxin Reductase and Flavodoxin Protect Cos-7 Cells from Oxidative Stress. PLoS One. 2010 Oct 19;5(10):e13501.
11. Gazzin S, Berengeno AL, Strazielle N, Fazzari F, Raseni A, Ostrow JD, Wennberg R, Ghersi-Egea JF, and Tiribelli C. Modulation of Mrp1 (ABC c1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS ONE 2011, 6(1): e16165. i:10.1371/journal.pone.0016165
12. Mandala S, Rosso N, Tiribelli C, Scoles G and Krol S. Targeted Multicomponent Polysomes for High Efficiency, Simultaneous Anti-sense and Gene Delivery. Soft Matter, 2011, 7 (19):9424- 9434
13. Bedogni G, Kahn HS, Bellentani S, Tiribelli C. Non-invasive estimation of fatty liver in populations or primary care settings, BMJ (Letter to the Editor),

Review papers:
1. Sukowati CHC, Rosso N, Crocè LS, Tiribelli C. World Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma. World J Hepatol 2010, 2(3): 114-126
2. Chavez-Tapia NC, Rosso N, Tiribelli C. In vitro models for the study of non-alcoholic Fatty liver disease. Curr Med Chem. 2011;18(7):1079-84.
3. Gazzin S and Tiribelli C. Bilirubin-induced neurological damage. Journal of Maternal-Fetal & Neonatal Medicine, 2011, 24 (S1): 154-155
Project Title:
Molecular basis of liver disease
Details wil be discussed with interested applicants