Bert Blaauw
Bert Blaauw
affiliation: Università di Padova
research area(s): Neuroscience, Molecular Biology
Course: Biosciences and Biotechnologies
University/Istitution: Università di Padova
Assistant professor at the physiology department, young PI at the Venetian Institute of Molecular Medicine
Adult skeletal muscle is an extremely plastic tissue, rapidly modifying its size and function responding to changes in demands. In the lab we are focusing our attention on the intracellular signaling pathways regulating increases in both mass and function of adult skeletal muscle. Considering the significant problems which arise during aging, disuse and numerous other pathologies leading to muscle atrophy and weakness, together with the well-established beneficial effect of exercise, it is of fundamental importance to understand which pathways regulate muscle growth and how these can be linked to exercise.
1. Bert Blaauw, Paola del Piccolo, Laura Rodriguez, Victor-Hugo Hernandez Gonzalez, Lisa Agatea, Francesca Solagna, Fabio Mammano, Tullio Pozzan, and Stefano Schiaffino. No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in adult mouse skeletal muscle fibers. J Gen Physiol. 2012 Aug;140(2):235-41. Epub 2012 Jul 16
2. Blaauw B*, Agatea L, Toniolo L, Canato M, Quarta M, Dyar KA, Danieli-Betto D, Betto R, Schiaffino S, Reggiani C. Eccentric contractions lead to myofibrillar dysfunction in muscular dystrophy. J Appl Physiol. 2010 Jan;108(1):105-11. *corresponding
3. Blaauw B*, Canato M, Agatea L, Toniolo L, Mammucari C, Masiero E, Abraham R, Sandri M, Schiaffino S, Reggiani C. Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation. FASEB J. 2009 Nov;23(11):3896-905. *corresponding
4. Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, Metzger D, Reggiani C, Schiaffino S, Sandri M. Autophagy is required to maintain muscle mass. Cell Metab. 2009 Dec;10(6):507-15.
5. Blaauw B, Mammucari C, Toniolo L, Agatea L, Abraham R, Sandri M, Reggiani C, Schiaffino S. Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle. Hum Mol Genet. 2008 Dec 1;17(23):3686-96.
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