Solomon G. Nergadze
Solomon G. Nergadze
e-mail:
affiliation: Department of Biology and Biotechnology - UNIPV
research area(s): Molecular Biology, Cell Biology
Course: Genetics, Molecular and Cellular Biology
University/Istitution: Università di Pavia
Dr. Solomon G. NERGADZE

PERSONAL DATA
BIRTH DATE: January 31, 1960
BIRTH PLACE: Bagdati, Georgia (The Republic of Georgia)
Citizenship: Italian
RESIDENCE: Via Folperti 16, 27100 Pavia, Italy
ADDRESS (Off): Laboratories of Genetics and Microbiology, Department of Biology and Biotechnology, University di Pavia, Via Ferrata 1, 27100 Pavia (Italy)
Tel.: (+39 0382) 98 55 40, Fax: (+39 0382) 52 84 96
Tel.: (+39 0382) 46 94 41 (home), (+39) 340 87 99 580 (cell phone)
E-mail: nergadze@ipvgen.unipv.it
MARITAL STATUS: Widowed, two children (20 and 17 years).
LANGUAGES: Georgian (native), English, Italian and Russian.

EDUCATION
30 Nov. 2010 Ph.D in Genetics and Biomolecular Sciences;
Thesis Title: "Mammalian genome plasticity: telomere transcription, origin of interstitial telomeric sequences and centromere movement." Università degli Studi di Pavia, Pavia, Italy, 11 Gen. 2010
1 Oct. 2006 - 30 Sep. 2009 Doctorate in Genetics and Biomolecular Sciences at the Department of Genetics and Microbiology “A. Buzzati Traverso”, University of Pavia, Pavia, Italy;
1 Feb. 1996 – 31 Jan. 1998 ICGEB (International Center for Genetic Engineering and Biotechnology) Postdoctoral Fellowship in Molecular Biology at the Department of Genetics and Microbiology, University of Pavia, Pavia, Italy (The certificate issued by the ICGEB, Jan, 31, 1998);
6 Mar. 1992 Ph.D in Biological Sciences - Cellular Biology. Thesis Title: “DNA replication in cells from patients with inherited diseases of chromosomal instability.”Institute of Cytology, St. Peterburg, Russia, 20 Dic. 1991 (Ph.D Diploma issued by Accademy of Sciences of USSR, 6/03/1992);
1987 – 1991 Doctorate in Cellular Biology at the Institute of Cytology, St.Peterburg, Russia;
23 Jun. 1982 Graduated from Ivane Javakhishvili Tbilisi State University (Diploma cum laude), Faculty of Physics, Majored in Biophysics, Tbilisi, Georgia.
1977 Graduated from Kutaisi College of Physics, Mathematics and Natural Sciences (Diploma cum laude), Kutaisi, Georgia.

PROFESSIONAL EXPERIENCE
From Oct. 1, 2011 Assistant Professor of Molecular Biology (BIO/11 - Molecular Biology), Department of Biology and Biotechnology, University of Pavia, Pavia, Italy;
2002 - 2011 Laboratory of Molecular and Cellular Biology, Department of Genetics and Microbiology, University of Pavia, Pavia, Italy;
2001 - 2002 Laboratory of Medical Genetics, Institute of Informatics and Complex Automation of Public Health, Ministry of Health, Tbilisi, Georgia;
2000 - 2001 Visiting Scientist, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada;
1998 - 1999 Section of General Biology and Medical Genetics, Department of Human Pathology and Hereditary, University of Pavia, Pavia, Italy;
1996 - 1998 Laboratory of Molecular and Cellular Biology, Department of Genetics and Microbiology, University of Pavia, Pavia, Italy;
1984 - 1996 Department of Applied Molecular Biology and Laboratory of Molecular Biology, Centre of Genetic Ecology, Ministry of Health, Tbilisi, Georgia;
1982 - 1984 Laboratory of Molecular Genetics, Institute of Plant Biochemistry, Georgian Accademy of Sciences, Tbilisi, Georgia.


PUBLICATIONS
The list of publication comprises 40 full papers in peer reviewed journals, 1 volume contribution (assay), 67 meeting abstracts and 6 pubblications in other (Russian, Georgian, ecc.) journals
Centromere function and evolution
Genome Research 2017 (submitted)
Mol Cytogenet 2016 (doi: 10.1186/s13039-016-0242-z)
Chromosoma 2015 (doi: 10.1007/s00412-014-0493-6)
Hereditas 2011 (DOI: 10.1111/j.1601-5223.2011.02218.x)
PLoS Genet 2010 (DOI: 10.1371/journal.pgen.1000845)
Science 2009 (DOI: 10.1126/science.1178158)
Cytogenet Genome Res 2009 (DOI: 10.1159/000245916)
Genomics 2006 (DOI: 10.1016/j.ygeno.2005.11.012)

• Telomere transcription
Front. Oncol. 2013 (DOI: 10.3389/fonc.2013.00245)
Front. Oncol. 2013 (DOI: 10.3389/fonc.2013.00115)
RNA 2009 (DOI: 10.1261/rna.1748309)

• Telomerase and DNA Repair,
Chromosoma 2012 ( DOI: 10.1007/s00412-012-0379-4)
Cytogenet Genome Res 2008 (DOI: 10.1159/000167807)
Genome Biol. 2007 (DOI: 10.1186/gb-2007-8-12-r260)

• Interstitial telomeric sequences in mammalian genomes
Genome Res. 2004 (DOI: 10.1101/gr.2778904)
Chromosoma 2001 (DOI: 10.1007/s004120100135)
Cytogenet Genome Res 2008 (DOI: 10.1159/000167807)

• Gene amplification in DNA-PKcs inhibited cells using the RNAi approach;
Genome Integrity 2011, DOI: 10.1186/2041-9414-2-5
DNA Repair 2009 (DOI: 10.1016/j.dnarep.2008.08.015)

• Mitochondrial DNA and mtDNA insertions in the nuclear horse genome
Proc Natl Acad Sci U S A. 2012, DOI: 10.1073/pnas.1111637109
Animal Genetics (Invited submission) 2010, DOI: 10.1111/j.1365-2052.2010.02130.x

Most important projects in past:
- Immortalization of primary fibroblasts from equus species through an ectopic expression of the human telomerase;
- Genome organization of cell lines established from human gastric carcinoma;
- Telomeres and cell senescence;
- DNA replication in irradiated cells from patients with inherited diseases of chromosome instability.
40 Full papers in peer reviewed journals (PubMed)
1 volume contribution (assay),
68 meeting abstracts
6 pubblications in other (Russian, Georgian, ecc.) journals

1. Nergadze SG, Piras FM, Gamba R, Corbo M, Cerutti F, McCarter JGW, Cappelletti E, Gozzo F, Harman RM, Antczak DF, Miller D, Scharfe M, Pavesi G, Raimondi E, Giulotto E. (2017) Birth, evolution and transmission of mammalian centromeric domains. Genome Research (submitted)
2. Santagostino M†, Khoriauli L†, Gamba R†, Bonuglia M, Klipstein O, Piras FM, Vella F, Russo A, Badiale C, Mazzagatti A, Raimondi E, Nergadze SG*, Giulotto E*. Genome-wide evolutionary and functional analysis of the Equine Repetitive Element 1: an insertion in the myostatin promoter affects gene expression. BMC Genet. 2015 Oct 26;16:126. doi: 10.1186/s12863-015-0281-1. NC: 0, IF: 2.48 (†, Equal contributors; *, corresponding authors)
3. Purgato S, Belloni E, Piras FM, Zoli M, Badiale C, Cerutti F, Mazzagatti A, Perini G, Della Valle G, Nergadze SG, Sullivan KF, Raimondi E, Rocchi M, Giulotto E. (2015) Centromere Sliding on a Mammalian Chromosome. Chromosoma 124(2):277-287. doi: 10.1007/s00412-014-0493-6. Epub 2014 Nov 21, PMID: 25432774 Codice ISI: 000355146500012, Codice SCOPUS: 2-s2.0-84929956603 NC: 8, IF: 3.87
4. Smirnova A, Gamba R, Khoriauli L, Vitelli V, Nergadze SG*, Giulotto E*. (2013) TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front. Oncol. 3:115. Published online: 18 Sept. 2013. DOI: 10.3389/fonc.2013.00115, PMID: 23717814. ISSN: 2234-943X. (*, corresponding authors) Codice ISI: Not yet, Codice SCOPUS: 2-s2.0-84891074830 (Front Oncol. is published from 2011). NC: 7, IF: 2.77
5. Achilli A, Olivieri A, Soares P, Lancioni H, Hooshiar Kashani B, Perego UA, Nergadze SG, Carossa V, Santagostino M, Capomaccio S, Felicetti M, Al-Achkar W, Penedo MCT, Verini-Supplizi A, Houshmand M, Woodward SR, Semino O, Silvestrelli M, Giulotto E, Pereira L, Bandelt H-J, Torroni A. (2012) Mitochondrial Genomes from Modern Horses Reveal the Major Haplogroups that Underwent Domestication. Proc Natl Acad Sci U S A. 109:2449-2454. DOI: 10.1073/pnas.1111637109, PMID: 22308342, Codice ISI: 000300489200060 Codice SCOPUS: 2-s2.0-84857124895, NC: 62, IF: 9.49
6. Nergadze SG, Lupotto M, Pellanda P, Santagostino M, Vitelli V, Giulotto E. (2010) Mitochondrial DNA insertions in the nuclear horse genome. Animal Genetics (Invited submission, special issue of Animal Genetics) 41 Suppl 2:176-85. DOI: 10.1111/j.1365-2052.2010.02130.x, PMID: 21070293, ISSN: 0268-9146, Codice ISI: 000284117700026 Codice SCOPUS: 2-s2.0-78449284241, NC: 17, IF: 2.00 (for year 2010)
7. Piras FM*, Nergadze SG*, Magnani E, Bertoni L, Attolini C, Khoriauli L, Raimondi E, Giulotto E. (2010) Uncoupling of Satellite DNA and Centromeric Function in the Genus Equus. PLoS Genet 6: e1000845. (*, These authors contributed equally to this work). DOI: 10.1371/journal.pgen.1000845, PMID: 20169180, ISSN: 1553-7390, Codice ISI: 000275262700025 Codice SCOPUS: 2-s2.0-77649206825 , NC: 33, IF: 7.53 (by year 2011)
8. Nergadze SG, Farnung BO, Wischnewski H, Khoriauli L, Vitelli V, Chawla R, Giulotto E, Azzalin CM. (2009) CpG-island promoters drive transcription of human telomeric repeat-containing RNA. RNA 15: 2186-2194. DOI: 10.1261/rna.1748309, PMID: 19850908, ISSN: 1355-8382, Codice ISI: 000272169000010 Codice SCOPUS: 2-s2.0-73249117060, NC: 86, IF: 5.34 (by year 2011)
9. Nergadze SG, Santagostino M, Salzano A, Mondello C, Giulotto E. (2007) Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution. Genome Biol 8: R260. DOI: 10.1186/gb-2007-8-12-r260. PMID: 18067655 ; ISSN:1474-760X, Codice ISI: 000253451800008 Codice SCOPUS: 2-s2.0-40449109731, NC: 44, IF: 6.69 (by year 2011)
10. Carbone L, Nergadze SG, Magnani E, Misceo D., Cardone MF, Roberto R, Bertoni L, Attolini C, Piras MF, de Jong P, Raudsepp T, Chowdhary BP, Guérin G, Archidiacono N, Rocchi M, Giulotto E. (2006) Evolutionary movement of centromeres in horse, donkey, and zebra. Genomics 87: 777-782. DOI: 10.1016/j.ygeno.2005.11.012. PMID: 16413164; ISSN: 0888-7543, Codice ISI: 000238168400010 Codice SCOPUS: 2-s2.0-33646839266, NC: 56, IF: 3.33 (by year 2011)
11. Nergadze SG, Rocchi M, Azzalin CM, Mondello C, Giulotto E. (2004) Insertion of Telomeric Repeats at Intrachromosomal Break Sites During Primate Evolution. Genome Res 14: 1704-1710. DOI: 10.1101/gr.2778904. PMID: 15310657; ISSN: 1088-9051, Codice ISI: 000223675900004 Codice SCOPUS: 2-s2.0-4644329310, NC: 56, IF: 13.83 (by year 2011)
12. Azzalin CM, Nergadze SG, Giulotto E. (2001) Human intrachromosomal telomeric-like repeats: sequence organization and mechanisms of origin. Chromosoma 110:75-82. DOI: 10.1007/s004120100135. PMID: 11453557; ISSN: 0009-5915, Codice ISI: 000169207900002 Codice SCOPUS: 2-s2.0-0034994404, NC: 114, IF: 3.69 (by year 2011)
No projects are available to students for the current accademic year.