Fausto Baldanti
Fausto Baldanti
affiliation: Dpt. of Clinical, Surgical, Diagnostics and Pediatric Sciences - UNIPV
research area(s): Immunity And Infection, Genetics And Genomics
Course: Genetics, Molecular and Cellular Biology
University/Istitution: Università di Pavia
1990 Graduation as Medicine Doctor, Università degli Studi di Pavia, Italy 110/110 Cum Laude
1995 Specialization in Infectious Diseases, Università degli Studi di Pavia, Italy 50/50 Cum Laude
2004 Specialization in Microbiology and Virology, Università degli Studi di Padova, Italy 70/70 Cum Laude

1994-2010 Staff MD, Laboratori Sperimentali di Ricerca, Area Infettivologica, Fondazione IRCCS Policlinico San Matteo, Pavia in quality of:
2010-2014 Head, Molecular Virology Unit, Virology and Microbiology Dpt., Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
1/11/14-present Associate Professor, Dpt. of Clinical, Surgical, Diagnostics and Pediatric Sciences, University of Pavia, Pavia, Italy

Professional assignments
since 1998 Contract Professor, Infectious Diseases Post-Graduation School, Pavia University, Pavia
2004-2005 Contract Professor, Virology, Biotechnology School, Vita-Salute San Raffaele University, Milano
2009-2011 Contract Professor, Virology, Biotechnology School, Pavia University, Pavia
2010-2011 Contract Professor, Microbiology and Virology Post-Graduation School, Pavia University, Pavia
2011-2012 Contract Professor, Laboratory Technical School, Pavia University, Pavia
2012 Contract Professor, Virology English Medicine School, Pavia University, Pavia
2013 Contract Professor, Virology, Biotechnology School, Pavia University, Pavia
2017 Director, School of Specialization in Microbiology and Virology, University of Pavia

1994-1996 Dept. of Virology, Glaxo-Wellcome Inc. Duhram, NC, USA (mechanisms of antiviral drug resistance in human cytomegalovirus and hepatitis B virus)
1998 Aviron, Mountain View, CA e Ist. Microbiology and Immunology, Stanford University, Stanford,CA, USA (human citomegalovirus cosmid library)
2000 Max von Pettenkofer Institut, University of Munich, Munich, Germany (cloning and mutagenesis of human cytomegalovirus genome in BAC)

Scientific activity
Coauthor of 279 papers published on International scientific journals quoted in Medline (h-index 46)
Coauthor of more than 450 presentations (oral and poster) at Italian and International Congresses

Member of the Editorial Board of Journal of Clinical Virology (2009-2010); Committee for Internal Audit, Journal of Clinical Virology (2010-2012); Associate Editor Journal of Clinical Virology (2012-present);Editorial Board Antiviral Research(2011-2012) , Editorial Board New Microbiologica (2012-present), Editorial Board PlosONE (2014-present)
Referee for: Haematologica, Antiviral Research, Journal of Antimicrobial Chemotherapy, Journal of Clinical Virology, Clinical Microbiology and Infection, BioMed Central Infectious Diseases, Journal of Infectious Diseases, Antimicrobial Agents and Chemotherapy, Journal of General Virology, European Journal of Infectious Diseases and Clinical Microbiology, Clinical Infectious Diseases, Journal of Medical Virology, BioMed Central Critical Care , Liver Transplantation, Transplant Infectious Diseases; Diagnostic Microbiology and Infectious Diseases, HIV Therapy; Current HIV Research; PloS One; Antiviral Chemistry & Chemotherapy; Emerging Infectious Diseases; Eurosurveillance¸ Expert Review of Clinical Immunology, Journal of Medical Microbiology.
• Translational research on respiratory viral infections: As Regional Reference Center for the diagnosis of severe respiratory infections and Regional Reference Center for the Italian Influenza Surveillance Network (INFLUNET) of Influenza Virus Infections, our Unit is devoted to the surveillance and molecular epidemiology of influenza viruses. In addition, our group contributed to the understanding of pathogenetic mechanisms of severe respiratory virus infections (including the identification of new viruence factors and the analysis of immune response in severe respiratory syndromes). Finally, a significant impact in developing new approaches to diagnosing viral infections in different goups of pts is acknowledged to our research group.
• Translational research on emerging and reemerging viruses: As a Regional Reference Center for emerging virus infections, our group is involved in the development and application of advanced diagnostic methods for the identification and typing of arbovirus infections (Phleboviruses, Dengue, West-Nile, Zikav and chikungunya virus). Our research activity has allowed the identification of broadly reacting and potentially protective human antibodies for mosquito-associated flavivirus. T-cell immune response specific for emerging viruses is presently under investigation for its protective role during Zika virus infection in pregnancy. In addition, our group conrtibuted significantly in the surveillance and molecular epidemiology of arbovirus infections as well as of other emerging (EVD68, EV-D71, parechovirus) and reemerging (measles) viruses.
• Virological and immunological monitoring of viral opportunistic infections in immunocompromised patients: An important translation path of our Unit is linked to the innovation of both (virological and immunological) monitoring parameters of opportunistic infections in immunocompromised patients, in particular solid organ and hematopoietic stem cell transplanted patients. A number of innovative approaches for the determination of T-cell response to CMV, EBV, VZV, HSV (and other opportunistic infections) have been developed. In addition, (mono- bi-and multicenter) clinical trials to determine their prognostic role for a better management of transplanted patients have been recently promoted.
• Monitoring and management of viral infections in pregnancy: A prominent role in both translational and basic research for the management of human cytomegalovirus (HCMV) and rubella viruses infections during pregnancy is acknowledged to our Unit. The spectrum of activities encompasses the definition of pathogenetic molecular mechanisms as well as immunologic (both B- and T-cell mediated) response parameters. Our experience in this field and the ongoing collaborations has enabled us to confron with the emergence of Zika virus infection in pregnancy according a similar approach, obtaining high profile scientific results.
Di Maio VC, et al. Frequent NS5A and multiclass resistance in almost all HCV genotypes at DAA failures: what are the chances for second-line regimens? J Hepatol. 2017 Sep 20. pii: S0168-8278(17)32288-2.

Navarro D, et al. Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey. Transpl Infect Dis. 2017 Aug 31.

Gerna G, et al. The pentameric complex of human Cytomegalovirus: cell tropism, virus dissemination, immune response and vaccine development. J Gen Virol. 2017 Sep;98(9):2215-2234.

Percivalle E, et al. Usutu Virus Antibodies in Blood Donors and Healthy Forestry Workers in the Lombardy Region, Northern Italy. Vector Borne Zoonotic Dis. 2017 Sep;17(9):658-661.

Balmaseda A, et al. Antibody-based assay discriminates Zika virus infection from other flaviviruses. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8384-8389.

Zehender G, et al. Reconstructing the recent West Nile virus lineage 2 epidemic in Europe and Italy using discrete and continuous phylogeography. PLoS One. 2017 Jul 5;12(7):e0179679.

Scudeller L, et al. Occult HIV infection in a large sample of health-care users in Lombardy, Italy in 2014-2015: implications for control strategies. Epidemiol Infect. 2017 Aug;145(11):2352-2359.

Piralla A, et al. Frequency of respiratory virus infections and next-generation analysis of influenza A/H1N1pdm09 dynamics in the lower respiratory tract of patients admitted to the ICU. PLoS One. 2017 Jun 7;12(6):e0178926. doi: 10.1371/journal.pone.0178926.

Piralla A, et al. Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009-2016) in Northern Italy. J Clin Virol. 2017Jul;92:48-51.

Piralla A, et al. FilmArray™ GI panel performance for the diagnosis of acute gastroenteritis or hemorrhagic diarrhea. BMC Microbiol. 2017 May 12;17(1):111. doi: 10.1186/s12866-017-1018-2.

Cento V, et al. Optimal efficacy of interferon-free HCV retreatment after protease inhibitor failure in real life. Clin Microbiol Infect. 2017 Oct;23(10):777.e1-777.e4.

Rovida F, et al. Authors' reply: Two severe human cases due to swine influenza A (H1N1)v in October 2016 in Europe were chronologic coincident yet distinct events. Euro Surveill. 2017 Mar 9;22(10). pii: 30480.

Rovida F, et al. Swine influenza A (H1N1) virus (SIV) infection requiring extracorporeal life support in an immunocompetent adult patient with indirect exposure to pigs, Italy, October 2016. Euro Surveill. 2017 Feb;22(5). pii: 30456.

Pariani E, et al. Letter to the editor: Need for a European network for enterovirus D68 surveillance after detections of EV-D68 of the new B3 lineage in Sweden and Italy, 2016. Euro Surveill. 2017 Jan 12;22(2). pii: 30440.

Paolucci S, et al. HCV intergenotype 2k/1b recombinant detected in a DAA-treated patient in Italy. Antivir Ther. 2017;22(4):365-368.

Amendola A, et al. Measles re-emergence in Northern Italy: Pathways of measles virus genotype D8, 2013-2014. Infect Genet Evol. 2017 Mar;48:120-126.

Zavattoni M, et al. Miscarriage following dengue virus 3 infection in the first six weeks of pregnancy of a dengue virus-naive traveler returning from Bali to Italy, April 2016. Euro Surveill. 2016 Aug 4;21(31).

Zavattoni M, et al. Monitoring of human cytomegalovirus DNAemia during primary infection in transmitter and non-transmitter mothers. J Clin Virol. 2016 Sep;82:89-93.

Abbate I, et al. Nation-wide measure of variability in HCMV, EBV and BKV DNA quantification among centers involved in monitoring transplanted patients. J Clin Virol. 2016 Sep;82:76-83.

Zavattoni M, et al. Diagnostic and prognostic value of molecular and serological investigation of human parvovirus B19 infection during pregnancy. New Microbiol. 2016 Jul;39(3):181-185.

Stettler K, et al. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection. Science. 2016 Aug 19;353(6301):823-6.

Cassaniti I, et al. Memory T cells specific for HBV enumerated by a peptide-based cultured enzyme-linked immunospot assay in healthy HBV-vaccinated subjects. Hum Vaccin Immunother. 2016 Nov;12(11):2927-2933.

Narra R, et al. Acute respiratory distress syndrome in adenovirus type 4 pneumonia: A case report. J Clin Virol. 2016 Aug;81:78-81.

Fattuoni C, et al. Primary HCMV infection in pregnancy from classic data towards metabolomics: An exploratory analysis. Clin Chim Acta. 2016 Sep 1;460:23-32.

Rovida F, et al. Evaluation of Xpert® Norovirus Assay performance in comparison with real-time RT-PCR in hospitalized adult patients with acute gastroenteritis. Diagn Microbiol Infect Dis. 2016 Aug;85(4):426-7.

Colombo AA, et al. Neurological Complications Involving the Central Nervous System After Allogeneic Hematopoietic Stem Cell Transplantation During a Period of Evolution in Transplant Modalities: A Cohort Analysis. Transplantation. 2017 Mar;101(3):616-623.
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