Marco Terreni
Marco Terreni
affiliation: University of Pavia
research area(s): Developmental Biology, Chemical Biology
Course: Biomolecular Sciences and Biotechnology
University/Istitution: Istituto Universitario di Studi Superiori, Pavia
Full Professor of Medicinal Chemistry; Faculty of Pharmacy (Biotechnology Course), University of Pavia, Italy
1990 Degree in Chimica e Tecnologia Farmaceutiche (110/110 cum laude), University of Pavia, Italy. Thesis: “Synthesis and evaluation of the antimicrobic activity of fluoro substituted dithiobisbenzamides and benzoisothiazolones”, Tutor: Prof. G. Pagani, Department of Pharmaceutical Chemistry, University of Pavia, Italy.
1992 Master in Chemical Synthesis, (86/100), Politecnico of Milano, Italy. Thesis: “Use of enzymes in organic chemistry”, Tutor: Prof. C. Fuganti, Department of Organic Chemistry, Politecnico of Milano, Italy.
1997 Ph.D. in Chimica e Tecnologia Farmaceutiche, University of Pavia, Italy. Thesis: “New methodologies for the kinetically controlled synthesis of Ampicillin, Cefazolin and Cefamandole, catalyzed by penicillin acylases”.
Design and preparation of efficient biocatalyst by mutagenesis and immobilization of enzymes
- Acylases
- Lipases
- Esterases
- Nucleoside Phosphorylase
- Kinases
Enzymatic synthesis of drugs: development of new processes
- Synthesis of -lactamic antibiotics catalyzed by immobilized penicillin acylases
- Resolution of racemic mixtures by enzymatic catalysts
- Selective protection and deprotection of sugars catalyzed by immobilized lipases and synthesis of oligosaccharides
- Nucleosides synthesis by enzymatic transglycosylation catalyzed by Uridine Phosphorylase and Purine Nucleoside Phosphorylase
Pharmaceutical Chemistry
-study of neo-glycoproteins as potential vaccines
Marco Filice, Jose M. Palomo, Paolo Bonomi, Teodora Bavaro, Roberto Fernandez-Lafuente, Jose M. Guisan, and Marco Terreni “Preparation of linear oligosaccharides by a simple monoprotective chemo-enzymatic approach” Tetrahedron 64, 9286-9292 (2008).

Marco Filice, Teodora Bavaro, Roberto Fernandez-Lafuente, Massimo Pregnolato, Jose M Guisa, Jose M Palomo and Marco Terreni “Chemo-Biocatalytic Regioselective One Pot Synthesis of Different Deprotected Monosaccharides” Catalysis Today; 140 (1-2), 11-18 (2009)

Immacolata Serra, Davide A. Cecchini, Daniela Ubiali, Elena M. Manazza, Alessandra M. Albertini, Marco Terreni “Coupling of site-directed mutagenesis and immobilization for the rational design of more efficient biocatalysts. The case of immobilized 3G3K PGA from E. coli. Eur. J. of Org. Chem. 9, 1384-1398 (2009)

Bonomi Paolo, Cairoli Paola, Ubiali Daniela, Morelli Carlo F., Filice Marco, Nieto Ines, Pregnolato Massimo, Manitto Paolo, Terreni Marco, Speranza Giovanna; “Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases” Tetrahedron Asymmetry. 20 467-472 (2009)

Bavaro Teodora, Rocchietti Silvia, Ubiali Daniela, Filice Marco, Terreni Marco, Pregnolato Massimo.”A Versatile Synthesis of 5'-Functionalized Nucleosides Through Regioselective Enzymatic Hydrolysis of Their Peracetylated Precursors” Eur. J. of Org. Chem. 12, 1967-1975 (2009)

Marco Filice, Renzo Vanna, Marco Terreni, Jose M. Guisan, e Jose M. Palomo “Lipase-Catalyzed Regioselective One-Step Synthesis of Penta-O-acetyl-3-hydroxylactal” Eur. J. of Org. Chem. 12, 3327-3329 (2009)

Teodora Bavaro, Daniela Ubiali, Stefania Brocca, Silvia Rocchietti, Ines Nieto, Massimo Pregnolato, Marina Lotti, Marco Terreni “Recombinant lipase from Candida rugosa for regioselective hydrolysis of peracetylated nucleosides. A comparison with commercial non recombinant lipases”. Biocatalysis and Biotrasformation, 28, (9) 108-116; (2010)

Caterina Temporini, Paolo Bonomi, Immacolata Serra, Auro Tagliani, Teodora Bavaro, Daniela Ubiali, Gabriella Massolini, Marco Terreni“Characterization and study of the orientation of immobilized enzyme by tryptic digestion and HPLC-MS: design of an efficient catalyst for the synthesis of cephalosporins” Biomacromolecules, 11, 1623-1632 (2010)
Project Title:
Rational Design and Screening of new vaccines for TBC
The aim of this research project is the semi-synthesis and characterization of glycoprotein (neo-glycoproteins) rationally designed on the basis of well-defined antigens of Mycobacterium tuberculosis (MTB). These compounds will be tested as potential immunogenic agents. In particular, will be studied new potential vaccines obtained by conjugation of oligosaccharides structurally related to lipoarabinomannan (LAM), the major surface antigen MTB, and proteins selected because they are over-expressed by MTB during macrophage infection and they are potent T-cell epitopes . This strategy will afford vaccine potentially suitable to induce both the antibody and the cell-mediated responses against MTB.